A5011803795- Animal Nutrition and Physiology
- Osteoarthritis Treatment and Mechanisms
- Wound Healing and Treatments
- Tendon Structure and Treatment
- Animal Behavior and Welfare Studies
- Livestock and Poultry Management
- Knee injuries and reconstruction techniques
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Surgical Sutures and Adhesives
- Pressure Ulcer Prevention and Management
- Bone fractures and treatments
- Protease and Inhibitor Mechanisms
- Veterinary Equine Medical Research
- Diabetic Foot Ulcer Assessment and Management
- Periodontal Regeneration and Treatments
- Veterinary Orthopedics and Neurology
- Inflammatory Bowel Disease
- Viral-associated cancers and disorders
- Spine and Intervertebral Disc Pathology
- Diagnosis and Treatment of Venous Diseases
- Total Knee Arthroplasty Outcomes
- Fatty Acid Research and Health
- Cell Adhesion Molecules Research
- Hip disorders and treatments
University of Bristol
2015-2024
University of Zurich
2017
John Wiley & Sons (United States)
2017
Hudson Institute
2017
Malden Public Schools
2017
Animal Welfare Institute
2011-2014
Third Way
2012-2013
Institute of Infection and Immunity
2013
Cabot (United States)
2011
King's College London
2008
The main objectives of the study were to provide an accurate assessment current levels old breaks in end-of-lay hens housed a variety system designs and identify important risk factors. Sixty-seven flocks eight broad subcategories assessed at end production period. Within each flock, presence keel fractures was determined tibia, humerus bones dissected for measurement breaking strength. For house, variations internal design perching provision categorised effective heights differing...
Mechanical and biochemical analyses of cadaveric surgically removed discs.To test the hypothesis that fissures in annulus degenerated human discs are mechanically chemically conducive to ingrowth nerves blood vessels.Discogenic back pain is closely associated with fibrosus, vessels.Three complementary studies were performed. First, 15 contained a major fissure subjected 1 kN compression, while miniature pressure transducer was pulled through disc obtain distributions matrix compressive...
Background Fibrosis is a serious consequence of Crohn's disease (CD), often necessitating surgical resection. We examined the hypothesis that IL-13 may promote collagen accumulation within CD muscle microenvironment. Methods Factors potentially modulating deposition were in intestinal tissue samples from fibrotic (f) and compared with cancer control (C), ulcerative colitis (UC) uninvolved (u) CD. Mechanisms attributable to analysed using cell lines derived explants. Results In fCD extracts,...
ObjectiveTo examine effects of high omega-3 (n-3) polyunsaturated fatty acid (PUFA) diets on development osteoarthritis (OA) in a spontaneous guinea pig model, and to further characterise pathogenesis this model. Modern low n-3 PUFAs have been linked with increases inflammatory disorders, possibly including OA. However, is also thought bone density, which possible contributing factor Therefore we aim determine the net influence disease development.MethodOA-prone Dunkin-Hartley (DH) Guinea...
The belief that an intervertebral disc must degenerate before it can herniate has clinical and medicolegal significance, but lacks scientific validity. We hypothesised tissue changes in herniated discs differ from those without herniation. Tissues were obtained at surgery 21 11 non-herniated of similar degeneration as assessed by the Pfirrmann grade. Thin sections graded histologically, certain features quantified using immunofluorescence combined with confocal microscopy image analysis....
The integration of implanted cartilage is a major challenge for the success tissue engineering protocols. We hypothesize that in order effective to take place, matrix-free chondrocytes must be induced migrate between two surfaces. A chondrocyte/collagen-scaffold implant system was developed as method delivering dividing cells at interface Chondrocytes were isolated from bovine nasal septum and seeded onto both surfaces collagen membrane create implant. model discs sandwiched used effect...
Osteoarthritis (OA) of the hip is invariably viewed as a disease primarily affecting articular cartilage. Data presented in this report, however, demonstrate changes metabolic activity underlying trabecular bone tissue, processes which may represent significant factor pathogenesis OA. Trabecular tissue from OA subjects expressed significantly more matrix metalloproteinase (MMP)-2 (gelatinase A, 72 kDa type IV collagenase) when compared to age-matched osteoporotic (OP) and normal tissue....
n-3 polyunsaturated fatty acids (PUFAs) reduce the severity of chronic inflammatory bowel disease, probably by means reduction immune cell activation or enhancement epithelial barrier. Using severe combined immunodeficient (SCID) mouse model colitis, this study examined effect dietary PUFAs on development colitis and immunologic, epithelial, matrix parameters in intestines control colitic animals.SCID mice were fed n-3-enriched diet for 3 weeks before induction transplantation CD45RB T cells...
In recent years, it has become evident that limitations exist in our ability to meaningfully assess palaeodiet using stable isotope compositions. These part arise because many of the fundamental assumptions about tissue-diet relationships are poorly understood. order redress this deficiency, a controlled feeding experiment was undertaken define impact terrestrial- vs. marine-derived dietary protein consumption on consumer tissue carbon isotopic compositions (δ13C). Two generations pigs were...
A 25 patient study was conducted into the relationship between markers of collagen metabolism in venous ulcer exudates and healing status, their prognostic value predicting performance. Wounds were sampled on at least 5 occasions over 12 months, frequencies which determined by need for clinic attendance. Specimens taken from several sites each using sterile preweighed filters. Wound margins traced recorded collection. Sample evaluated severity as improving, static, or deteriorating according...
With age, the proximal sections of turkey leg tendons become calcified, and this phenomenon has led to their use as a model for collagen mineralization. Mineralizing tendon was used in study characterize further composition cross-linking calcified tissues. The cross-link profiles mineralizing are significantly different from those other collagenous matrices with characteristically low amounts hydroxylysyl-pyridinoline presence lysyl-pyridinoline pyrrolic cross-links. However, immature...
It is important to monitor the early stages of postoperative wound repair in order identify those problems associated with impaired healing. Many crucial cellular responses healing, such as inflammatory infiltration, angiogenesis and re-epithelialization, are made possible through action matrix metalloproteinases (MMPs). Expression MMP-2 MMP-9 elevated acute wounds, still greater levels found chronic indicating that uncontrolled proteolysis a characteristic retarded Therefore, comparative...
Objective— To compare a 3‐loop pulley suture pattern with 2 locking‐loop sutures for the repair of components canine Achilles mechanism. Study Design— In vitro biomechanical study. Animals— Forty‐eight paired tendons collected from 9 cadavers. Methods— Paired were repaired either or and tensile tested to failure. ensure accurate anastomosis gap measurement direct, non‐contact, method measurement, using digital video, was devised. Load initiating formation (defined as load at 1 mm gap)...
The objective of this study was to determine whether differences in the composition and metabolism extracellular matrix (ECM) canine anterior cruciate ligaments (ACLs) might relate mechanical properties knee. Variations ACL biochemistry knee mechanics could account for divergent predispositions ligament rupture.Eleven joints were obtained from both cadaveric Labrador Retrievers (rupture predisposed) ex-racing Greyhounds (non-rupture predisposed). Anterioposterior laxity tensile testing...