A5016661086- Veterinary Orthopedics and Neurology
- Peripheral Neuropathies and Disorders
- Peripheral Nerve Disorders
- Spinal Dysraphism and Malformations
- Veterinary Oncology Research
- Hereditary Neurological Disorders
- Human-Animal Interaction Studies
- Spine and Intervertebral Disc Pathology
- Head and Neck Surgical Oncology
- Spinal Cord Injury Research
- Veterinary Equine Medical Research
- Rabies epidemiology and control
- Herpesvirus Infections and Treatments
- Cerebrospinal fluid and hydrocephalus
- Epilepsy research and treatment
- Neuroscience and Neural Engineering
- Veterinary Pharmacology and Anesthesia
- Cardiovascular Conditions and Treatments
- Neurological diseases and metabolism
- Nerve Injury and Rehabilitation
- Toxoplasma gondii Research Studies
- Hip disorders and treatments
- Glioma Diagnosis and Treatment
- Anesthesia and Pain Management
- Neurogenetic and Muscular Disorders Research
University of Bristol
2014-2024
At Bristol
2016-2024
John Wiley & Sons (United States)
2018
Moss Landing Marine Laboratories
2018
Hudson Institute
2018
Royal Veterinary College
2017
The Langton Grammar School for Boys
2012
University of Cambridge
2008-2011
Queen's Hospital
2011
To describe the clinical signs and outcome of a large cohort dogs presenting with neurological secondary to Neospora caninum infection.
Infectious meningoencephalitides represent an important differential diagnosis for meningoencephalitis of unknown origin (MUO) in dogs. Treatment the latter requires immunosuppression, but laboratory test results infectious agents may take several days to return. This study investigated whether presence masticatory muscle changes on magnetic resonance imaging (MRI) head can be used distinguish dogs with neosporosis from those MUO at time diagnosis. Cases diagnosed or two referral centers...
ABSTRACT Background The comparative effectiveness of radiotherapy and surgery for treating intracranial meningioma is unknown. Objectives To compare survival after treatment suspected by either or radiotherapy. Animals Two hundred eighty‐five companion dogs with meningiomas presenting to 11 specialty clinics in three countries. Methods Parallel cohort comparison study on retrospective data. Dogs diagnosed board‐certified veterinary neurologists radiologists treated were identified through...
Abstract Background Traditionally, 6‐month courses of prednisolone are used to treat steroid‐responsive meningitis‐arteritis (SRMA), but this medication is associated with adverse effects that can lead poor quality life. Hypothesis/Objectives Resolution clinical signs and rate relapse SRMA would not be significantly different between a protocol 6‐week protocol. Animals Forty‐four hospital cases from multiple referral centers in the United Kingdom (2015‐2019). Twenty 44 were treated 24/44...
Although many interventions for acute spinal cord injury (SCI) appear promising in experimental models, translation directly from animals to human patients is a large step that can be problematic. Acute SCI occurs frequently companion dogs and may provide model ease translation. Recently, incision of the dura has been highlighted both research as means reducing intraspinal pressure, with view improving perfusion injured tissue enhancing functional recovery. Observational clinical data humans...
The neuronal ceroid lipofuscinoses (NCLs) are hereditary neurodegenerative disorders characterized by progressive declines in neurological functions, seizures, and premature death. NCLs result from mutations at least 13 different genes. Canine versions of the can serve as important models developing effective therapeutic interventions for these diseases. have been described a number dog breeds, including Chihuahuas. Studies were undertaken to further characterize pathology Chihuahua NCL...
To determine the incidence, outcome, and risk factors for postattenuation neurological signs (PANS) seizures after attenuation of single congenital portosystemic shunts (CPSS) in dogs.Retrospective cohort study.Dogs (N = 253) with CPSS.Medical records dogs treated by surgical a CPSS between February 2000 July 2015 were reviewed signalment preoperative postoperative clinical outcomes, including occurrence PANS. Univariable multivariable binary logistic regression was used to assess PANS...
Objectives To compare the proportions of dogs with thoracolumbar disc extrusion that lose pelvic limb pain perception if surgery is performed on day admission or delayed overnight. describe outcome those deteriorate to perception. Materials and Methods Retrospective, single centre study 273 client‐owned intact perception, but inability walk unaided their limbs. Dogs were subdivided into two groups: early (spinal decompression between examination at following morning), (did not undergo...
Meningioma is the most common primary brain neoplasm in dogs. Further information required regarding expected long-term prognosis of dogs following surgical resection an intracranial meningioma together with influence adjunctive therapies. Whilst there have been several studies reporting outcome surgery alone, use ultrasonic aspirator, combined radiotherapy and addition hydroxyurea, it currently unclear which type therapy associated favourable outcomes. The objective this study to describe...
Abstract Background Treatment options available for meningoencephalitis of unknown origin (MUO) in dogs are suboptimal, and currently, no single treatment protocol appears to be superior. Objectives Compare neurological deterioration rates at 7 days between with MUO treated corticosteroids alone or combined cytosine arabinoside (CA) continuous rate infusion (CRI) compare clinical survival 30 100 days. Animals Sixty‐nine magnetic resonance imaging (MRI) cerebrospinal fluid (CSF) features both...
Background Steroid‐responsive meningitis‐arteritis ( SRMA ) is an inflammatory disease of dogs that suspected to be immune‐mediated. The development other immune‐mediated diseases has been linked vaccinations, time the year, geographic location, sex, neuter status, and breed. Hypothesis/Objectives To identify if associated with vaccination, Animals Sixty cases 180 controls, all ≤24 months age matched for year presentation, from a referral hospital population in United Kingdom. Methods...
Abstract Background Although thoracic hemivertebra can cause neurological signs, they occur commonly in neurologically normal dogs. Objectives To evaluate whether computed tomography (CT) findings and factors associated with signalment be used to differentiate between dogs without signs hemivertebra. Animals One hundred sixty ≥1 hemivertebrae were retrospectively studied. This group consisted of 40 clinical caused by French Bulldogs, Pugs, English Bulldogs that underwent CT for reasons...
Background Limited information is available about prognostic factors for recovery after spinal cord injury ( SCI ) to the L4‐S3 segments. Previous research suggests that does not have a worse prognosis than T3‐L3 . Hypothesis/Objectives To elucidate regaining urinary continence and ambulation in dogs with compare Animals/Methods A retrospective study on 61 nonambulatory , matched compared 3 weeks onset. Prognostic explored using logistic regression used matching: nonchondrodystrophic >15...
Background The importance of Chiari‐like malformation ( CM ) in the generation clinical signs or formation syringomyelia dogs is incompletely understood, partly because prevalence various definitions unaffected unknown. Hypothesis/Objectives aims were: to estimate asymptomatic for syringomyelia, according 3 currently used definitions; and, investigate effect brachycephaly and head position during magnetic resonance MR imaging on estimates . Animals One ninety‐nine client‐owned without...
To evaluate whether screening tests used to identify infectious and neoplastic triggers for immune-mediated haemolytic anaemia, in particular a complete blood count differential, serum biochemistry profile, urine analysis (including culture), abdominal ultrasound thoracic radiographs, can steroid-responsive meningitis-arteritis.Retrospective descriptive review.Twenty-one meningitis-arteritis cases were identified which all had been performed. All changes neutrophilia, monocytosis,...
Abstract Background Creatine kinase (CK) and aspartate aminotransferase (AST) activity can be increased with myositis associated Toxoplasma Neospora infection in dogs. Hypothesis/Objectives Serum of CK AST used as a rapid screen for predicting positive serology meningoencephalitis caused by gondii or caninum dogs compared to noninfectious meningoencephalitis. Animals Eighty based on magnetic resonance imaging cerebrospinal fluid analysis. Methods Retrospective case‐control study. Serological...
An episodic movement disorder is described in a young German shorthaired pointer. Movement disorders are rare, but well‐described, neurological conditions human beings. attempt made to classify this using current guidelines. Unlike previously dogs, case responded very well two commonly used anticonvulsant therapies, suggesting that trial therapy with these drugs worthwhile similar cases.
To describe the clinical phenotype of a new motor disorder in Labrador Retrievers.Case series study. Seven young male Retrievers presented for evaluation stiff gait.All affected dogs had generalized muscular stiffness, persistent at rest and resulting restricted joint movements. They showed forward flexed posture, festinating gait, bradykinesia. Signs developed between 2 16 months age tended to stabilize adulthood. Needle electromyogram conscious state continuous unit activity resting...