A5071743074- Education Systems and Policy
- Youth Education and Societal Dynamics
- Blood disorders and treatments
- Glaucoma and retinal disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Myeloid Leukemia Research
- Tourism, Volunteerism, and Development
- Turtle Biology and Conservation
- Genetic Associations and Epidemiology
- interferon and immune responses
- Chronic Lymphocytic Leukemia Research
- Rabies epidemiology and control
- Chronic Myeloid Leukemia Treatments
- Global Educational Policies and Reforms
- Medicinal Plant Pharmacodynamics Research
- Hematopoietic Stem Cell Transplantation
- S100 Proteins and Annexins
- Coronary Interventions and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Toxoplasma gondii Research Studies
- Malaria Research and Control
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Genomics and Rare Diseases
- Advanced Neuroimaging Techniques and Applications
University of Bristol
2022-2025
University Hospitals Sussex NHS Foundation Trust
2024
Flinders Medical Centre
2023
At Bristol
2022
University Hospitals Bristol NHS Foundation Trust
2022
University Hospitals Bristol and Weston NHS Foundation Trust
2022
University of Illinois Urbana-Champaign
2018-2021
Beatson West of Scotland Cancer Centre
2018
St George's Hospital
2015
Victoria University of Wellington
2015
Lowering the diagnostic threshold for troponin is controversial because it may disproportionately increase diagnosis of myocardial infarction in patients without acute coronary syndrome. We assessed impact lowering on incidence, management, and outcome with type 2 or injury.Consecutive elevated plasma I concentrations (≥50 ng/L; n = 2929) were classified 1 (50%) infarction, injury (48%), 3 to 5 (2%) before after from 200 50 ng/L a sensitive assay. Event-free survival death recurrent was...
Abstract Barth syndrome (BTHS) is a rare genetic disease caused by mutations in the TAFAZZIN gene. It characterized neutropenia, cardiomyopathy and skeletal myopathy. Neutropenia BTHS associated with life-threatening infections, yet there little understanding of molecular physiological causes this phenomenon. We combined bone marrow analysis, CRISPR/Cas9 genome editing hematopoietic stem cells functional characterization circulating patient neutrophils to investigate role their progenitors....
Venetoclax with azacitidine is the standard of care for patients AML who are unfit intensive chemotherapy, however uncertainties remain regarding treatment schedule, accurate prognostication and outcomes treated outside clinical trials. The option venetoclax low-dose cytarabine (LDAC) also available, it not clear which may be a useful alternative. Here we report large real-world cohort 654 in 53 UK hospitals either (n=587) or LDAC (n=67). Median age was 73 59% had de novo AML. Most received...
Abstract Rare genetic diseases affect millions, and identifying causal DNA variants is essential for patient care. Therefore, it imperative to estimate the effect of each independent variant improve their pathogenicity classification. Our study 140 214 unrelated UK Biobank (UKB) participants found that them carries a median 7 previously reported as pathogenic or likely pathogenic. We focused on 967 diagnostic-grade gene (DGG) rare bleeding, thrombotic, platelet disorders (BTPDs) observed in...
Infectious meningoencephalitides represent an important differential diagnosis for meningoencephalitis of unknown origin (MUO) in dogs. Treatment the latter requires immunosuppression, but laboratory test results infectious agents may take several days to return. This study investigated whether presence masticatory muscle changes on magnetic resonance imaging (MRI) head can be used distinguish dogs with neosporosis from those MUO at time diagnosis. Cases diagnosed or two referral centers...
Neutrophil release of cytoplasmic granules containing antimicrobial agents is a critical component innate immunity. Neutrophils are widely implicated in other disease responses yet the overall extent neutrophil contribution to human health and incompletely characterized. To explore this further, we leveraged publicly available genetic data conduct Mendelian randomization phenome-wide association study (MR-PheWAS) traits 14,983 outcomes. Genetic proxies for count, granularity, serum...
Abstract Neutrophil release of cytoplasmic granules containing antimicrobial agents is a critical component innate immunity. Neutrophils are widely implicated in tissue inflammation however the extent neutrophil contribution to human health and disease incompletely characterized. To explore this further, we leveraged publicly available genetic data conduct Mendelian randomization phenome-wide association study (MR-PheWAS) traits 14,983 outcomes. Genetic proxies for count, granularity, serum...
Grade (G) 3B follicular lymphoma (FL) is a rare FL subtype which exists on histological continuum between 'lowgrade' (Grade 1, 2 and 3A FL) diffuse large B-cell (DLBCL) appearing to share features with each. Clinical characteristics outcomes are poorly understood due lack of adequate representation in prospective trials large-scale analyses. We analyzed 157 G3BFL cases from 18 international centers, two comparator groups; G3AFL (n=302) DLBCL (n=548). Composite histology or low-grade occurred...
'Benign ethnic neutropenia' (BEN) is a heritable condition characterized by lower neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic basis BEN remains subject extensive research. In this study, we aimed to dissect architecture underlying count variation through linear-mixed model genome-wide association study (GWAS) population ancestry (N = 5976). Malaria caused P. falciparum imposes tremendous public health burden on people living sub-Saharan...
Abstract Objective To compare basal and reflex tear osmolarity in healthy dogs to evaluate for correlation among film osmolarity, production, fern pattern. Animals studied The population consisted of 22 adult dogs. Procedures Reflex was measured both eyes using the I‐PEN ® VET osmometer 30 minutes following Schirmer test (STT‐1) measurement. Subsequently, two topical anesthetic application, lacrimal lake conjunctival fornices were dried, 3 later, measured. Tears extracted from dye‐free STT‐1...
Five-amino salicylic acids are recommended for use in the management of inflammatory bowel disease, cardiac complications a rare although recognised phenomenon.This report aims to highlight this serious but adverse reaction.We here case young man presenting with cardiogenic shock context recent mesalazine treatment severe ulcerative colitis.
Summary Granulocyte transfusions continue to be used in clinical practice, predominantly for treatment of refractory infection the setting severe neutropenia. There is biological plausibility effectiveness these patients with deficiencies neutrophils, either as a consequence disease or treatment. However, there chequered history conducting and completing interventional trials define optimal use, many uncertainties remain regarding schedule dose. Practice studies are severely limited by short...
We describe a case of lenvatinib (E7080) associated focal segmental glomerulosclerosis (FSGS) encountered during the treatment metastatic medullary thyroid cancer. Proteinuria is relatively common side effect VEGF-targeted treatments and can occasionally result in discontinuation. Here, we patient who developed secondary FSGS necessitating discontinuation at first but was subsequently rechallenged with anti-VEGF-targeted without recurrence proteinuria. Lenvatinib novel experimental agent...
ABSTRACT Barth syndrome (BTHS) is a rare genetic disease caused by mutations in the TAFAZZIN gene. It characterized neutropenia, cardiomyopathy and skeletal myopathy. Neutropenia BTHS associated with life-threatening infections, yet there little understanding of molecular physiological causes this phenomenon. We combined bone marrow analysis, CRISPR/Cas9 genome editing hematopoietic stem cells functional characterization circulating patient neutrophils to investigate role their progenitors....
Abstract Background Malaria caused by P. falciparum imposes a tremendous public health burden on people living in sub-Saharan Africa. Severe malaria is associated with high morbidity and mortality results from complications such as cerebral malaria, severe anaemia or respiratory distress. Individuals endemic regions often have reduced circulating neutrophil count due to heritable phenomenon called ‘benign ethnic neutropenia’ (BEN). Neutrophils defend against bacterial infections but been...