A5065247051- Inflammatory Bowel Disease
- Microscopic Colitis
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Adolescent and Pediatric Healthcare
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Gastrointestinal motility and disorders
- Health Systems, Economic Evaluations, Quality of Life
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Diagnosis and treatment of tuberculosis
- Eosinophilic Disorders and Syndromes
- Tuberculosis Research and Epidemiology
- Pancreatitis Pathology and Treatment
- Social Media in Health Education
- Folate and B Vitamins Research
- Esophageal Cancer Research and Treatment
City St George's, University of London
2025
St George’s University Hospitals NHS Foundation Trust
2014-2025
St George's, University of London
2003-2025
Institute of Infection and Immunity
2025
St George's Hospital
2014-2024
Jackson and Tull (United States)
2024
St George's Hospital
2007-2020
Genetic Analysis (Norway)
2019
University of London
2016
University Gastroenterology
2007-2015
Background & AimsSwallowed topical-acting corticosteroids are recommended as first-line therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized esophageal delivery sometimes effective, although given off-label. We performed a randomized, placebo-controlled trial to assess the effectiveness and tolerability of budesonide orodispersible tablet (BOT), which allows drug be delivered esophagus in adults with active EoE.MethodsWe double-blind, parallel study 88 EoE Europe....
Abstract The mechanisms by which the lifestyle risk factors obesity, physical inactivity, and low fiber intake predispose to colorectal cancer (CRC) are unclear. Chronic bowel inflammation predisposes malignancy in cases of inflammatory disease. Many for CRC associated with evidence systemic as indicated circulating levels C-reactive protein (CRP), but it is unknown how this relates at tissue level. Little known about degree general population that affect it. Therefore, we aimed assess...
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn’s (CD), is a costly condition in terms of morbidity healthcare utilization, with an increasing prevalence now approaching 1% the Western world. Endoscopic assessment IBD remains gold standard for diagnosis, evaluation treatment response determination post-operative recurrence, but expensive invasive. Biomarkers can facilitate non-invasive assessment, C-reactive protein faecal calprotectin as most widely available...
Abstract Background Ustekinumab is a mainstay of treatment for Crohn’s disease (CD) and has been shown to be effective safe. The SEQUENCE(1) trial found risankizumab superior ustekinumab at inducing endoscopic remission non-inferior with respect clinical remission. However, there lack real-world data investigating the effectiveness in ustekinumab-exposed patients active CD we therefore aimed assess this. Methods A retrospective, observational study was performed tertiary inflammatory bowel...
Background Patients presenting to gastroenterology clinics with symptoms suggestive of lower-bowel disorders often require extensive investigation differentiate functional from organic disease. C-reactive protein (CRP) is a sensitive marker systemic inflammation. Levels CRP are frequently raised in cases inflammatory bowel disease (IBD). However, using conventional assays, not all IBD have detectable level. Objective To determine whether new highly enzyme-linked immunosorbent assay (ELISA)...
Background Over 250 000 people in the UK are affected with inflammatory bowel disease (IBD) and approximately 10 new cases diagnosed every year. These chronic conditions have been shown to affect both work recreational activity. In general population, regular exercise has numerous benefits health well-being there additional for those IBD. However, IBD face significant challenges trying take exercise. Objective With renewed focus on sport brought about by recent London Olympics, Crohn's...
<h3>ABSTRACT</h3> Although COVID-19 was first recognised as an acute respiratory illness, extra-pulmonary manifestations are increasingly being recognised. Acute gastrointestinal side effects have been well reported with infection and estimated to affect around 17% of patients. With still a relatively new the chronic symptoms less characterised. Post-infectious irritable bowel syndrome (IBS) can occur following bacterial viral infections, ACE-2 receptors shown be present in tract SARS-Cov-2...
Background The National Health Service (NHS) is faced with increasing cost pressures that make the efficient use of resources paramount. Irritable bowel syndrome (IBS) places a large burden on NHS as it has been estimated at least 12% UK population affected. However, poor clinical coding makes accurate assessment this challenging. Objective To calculate primary-care prescribing and both hospital outpatient admission costs associated management IBS in England. Design main outcome measures...
Objective The aim of this study was to determine the prevalence vitamin D deficiency in a multicultural inflammatory bowel disease (IBD) cohort and predictors including ethnicity. Design Patients with IBD were recruited into dedicated database over 6-month period evaluated retrospectively. Setting Department Gastroenterology, St George's University Hospital, London, UK. Outcomes measured Clinical data demographics, ethnic group, phenotype by Montreal classification, level season tested...
Abstract Background Societal trends in recent decades have led to greater expression and awareness of gender identity however little is known about the unique healthcare needs people who identify as transgender or non-conforming (TGNC) particularly with regards impact also suffering from a chronic disease such inflammatory bowel (IBD). The duality identifying TGNC IBD (TGNC-IBD) poorly understood questions remaining on gender-affirming hormones vice versa, mental health challenges perianal...
Abstract Background The experience of transgender and gender non-conforming (TGNC) individuals in healthcare is under-researched particularly relation to the impact chronic diseases such as inflammatory bowel disease (IBD). IBD believed affect 1 123 United Kingdom (UK)(1) can have a profoundly negative upon both quality life mental health. However, duality suffering from identifying TGNC poorly understood there no data examining experiences these patient groups nor specific challenges that...
Objectives Prompt initiation of advanced therapy medications, encompassing biologics and small-molecule treatments, is crucial for the effective management inflammatory bowel disease (IBD). The time taken from decision to start an first administration, or (TAT), can vary significantly between individuals negatively affect course; however, our knowledge causes variation in TAT poor. We aimed investigate impact demographic factors on delays TAT. Methods A retrospective study, conducted at a...
Introduction There is an increasing burden of gastro-oesophageal reflux disease (GORD) and Barrett's oesophagus (BO), paralleled by incidence oesophageal adenocarcinoma. Methods Using the General Practice Research Database, we derived GORD BO cancer (OC) populations, between 1996 2005. Acid suppression treatment over study period was also studied. Results were 5860 patients with 1 25 519 GORD. The increased from 0.11 to 0.24/1000 men 0.06 0.11/1000 women. diagnosed in general practice...
Increasing use of diagnostic imaging in inflammatory bowel disease (IBD) has led to concerns about the malignant potential ionising radiation a cohort that have an increased lifetime risk gastrointestinal malignancy. The aim was quantify exposure IBD patients referred from primary care, determine predictors high and evaluate temporal trends over 20-year period.This retrospective study whereby were recruited outpatient clinic evaluated retrospectively. total cumulative effective dose (CED)...