A5079069766- Epilepsy research and treatment
- Veterinary Orthopedics and Neurology
- Pharmacological Effects and Toxicity Studies
- Human-Animal Interaction Studies
- Metabolism and Genetic Disorders
- Spinal Dysraphism and Malformations
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Infant Health and Development
- Cerebrospinal fluid and hydrocephalus
- Veterinary Oncology Research
- Congenital Anomalies and Fetal Surgery
- Neuroendocrine regulation and behavior
- Spine and Intervertebral Disc Pathology
- Drug Transport and Resistance Mechanisms
- Neurological diseases and metabolism
- Bacterial Infections and Vaccines
- SARS-CoV-2 detection and testing
- Veterinary Pharmacology and Anesthesia
- Veterinary Equine Medical Research
- SARS-CoV-2 and COVID-19 Research
- Advanced Chemical Sensor Technologies
- Neonatal and fetal brain pathology
- Head and Neck Surgical Oncology
- Rabies epidemiology and control
University of Veterinary Medicine Hannover, Foundation
2005-2025
Royal Veterinary College
2014-2025
Ghent University
2024
University of Veterinary Medicine
2015-2023
Laboklin (Germany)
2021
Artemis One Health Research Foundation
2021
Friedrich-Loeffler-Institut
2021
Ludwig-Maximilians-Universität München
2021
Utrecht University
2021
University of London
2010-2019
Dogs with epilepsy are among the commonest neurological patients in veterinary practice and therefore have historically attracted much attention regard to definitions, clinical approach management. A number of classification proposals for canine been published during years reflecting always parts current coming from human organisation International League Against Epilepsy (ILAE). It has however not possible gain agreed consensus, "a common language", terminology used between neurologists...
This article outlines the consensus proposal on diagnosis of epilepsy in dogs by International Veterinary Epilepsy Task Force. The aim this is to improve consistency clinical and research settings. diagnostic approach patient presenting with a history suspected epileptic seizures incorporates two fundamental steps: establish if events animal demonstrating truly represent so, identify their underlying cause. Differentiation from other non-epileptic episodic paroxysmal can be challenging....
As the COVID-19 pandemic continues to spread, early, ideally real-time, identification of SARS-CoV-2 infected individuals is pivotal in interrupting infection chains. Volatile organic compounds produced during respiratory infections can cause specific scent imprints, which be detected by trained dogs with a high rate precision.
Epidemiological evaluation of canine epilepsy is an under‐researched area. The objectives this study were to estimate prevalence and investigate risk factors for unknown origin (EUO) among dogs attending primary veterinary practices in the UK. clinical data analysed spanned a two‐year period included all 92 clinics participating VetCompass project. Five hundred thirty‐nine EUO cases identified giving 0.62% (95% CI 0.57% 0.67%). Males over 1.5 times as likely have compared with females 1.44...
Medical intractability, i.e. the absence of any response to anti-epileptic drug (AED) therapy, is an unresolved problem in many patients with epilepsy. Mechanisms intractability are not well understood, but may include alterations pharmacological targets and poor penetration AEDs into brain because increased expression multiple drug-resistance proteins, such as P-glycoprotein (Pgp; ABCB1), capable active extrusion various drugs, including AEDs. Increased Pgp has been reported tissue...
This report represents a scientific and working clinical consensus statement on seizure management in dogs based current literature expertise. The goal was to establish guidelines for predetermined, concise, logical sequential approach chronic starting with identification diagnosis (not included this report), reviewing decision‐making, treatment strategies, focusing issues related antiepileptic drug response monitoring, enhance patient quality of life. Ultimately, we hope provide foundation...
Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological genetic studies have been conducted to date, which all improved our knowledge general understanding of canine epilepsy, in particular those breeds studied. However, these also frequently revealed differences between the investigated with respect clinical features, inheritance prevalence rates. Awareness observation important for successful...
Common criteria for the diagnosis of drug resistance and assessment outcome are needed urgently as a prerequisite standardized evaluation reporting individual therapeutic responses in canine epilepsy. Thus, we provide proposal definition partial success patients with This consensus statement also suggests list factors aspects outcome, which should be considered addition to impact on seizures. Moreover, these expert recommendations discuss determine validity informative value trial an patient...
The disease complex Chiari-like malformation (CM) and syringomyelia (SM) has been associated with the development of neuropathic pain (NeP), commonly affects Cavalier King Charles spaniels (CKCS). This prospective cohort study followed 48 CKCSs CM and/or SM clinical signs suggestive NeP for a period 39 (±14.3) months from diagnosis. At end study, 36 dogs were still alive; five died an unrelated or unknown cause, seven euthanased due to severe NeP. During follow-up period, scratching, facial...
Quality of life (QoL) plays a significant role in the treatment dogs with idiopathic epilepsy (IE), yet is so far understudied. This study describes outcome evaluation an online questionnaire based on carer's perception focusing 62 QoL questions 159 IE. Results showed that seizure frequency, but not severity or presence cluster seizures, was significantly associated carer-perceived dog's QoL. Dogs receiving third-line antiepileptic drugs had lower perceived than those did not. Generalised...
Globally, epilepsy is a common serious brain disorder. In addition to seizure activity, associated with cognitive impairments including static present at onset, progressive seizure-induced and co-morbid dementia. Epilepsy occurs naturally in domestic dogs but its impact on canine cognition has yet be studied, despite dysfunction (CCD) recognised as spontaneous model of Here we use data from psychometrically validated tool, the rating (CCDR) scale, compare diagnosed idiopathic (IE) controls...
Abstract Manual tools for pain assessment from facial expressions have been suggested and validated several animal species. However, expression analysis performed by humans is prone to subjectivity bias, in many cases also requires special expertise training. This has led an increasing body of work on automated recognition, which addressed species, including cats. Even experts, cats are a notoriously challenging species assessment. A previous study compared two approaches ‘pain’/‘no pain’...
Epilepsy is a challenging multifactorial disorder with complex genetic background. Our current understanding of the pathophysiology and treatment epilepsy has substantially increased due to animal model studies, including canine but additional basic clinical research required. Drug-resistant an important problem in both dogs humans, since seizure freedom not achieved available antiseizure medications. The evaluation exploration pharmacological particularly non-pharmacological therapeutic...