A5054031159- Veterinary Orthopedics and Neurology
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Spine and Intervertebral Disc Pathology
- Veterinary Oncology Research
- Spinal Cord Injury Research
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Herpesvirus Infections and Treatments
- Rabies epidemiology and control
- Spinal Dysraphism and Malformations
- Neuroscience and Neuropharmacology Research
- Human-Animal Interaction Studies
- Bacterial Infections and Vaccines
- Diet and metabolism studies
- Microbial infections and disease research
- Veterinary Equine Medical Research
- Shoulder Injury and Treatment
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Toxoplasma gondii Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Virus-based gene therapy research
- Neurological diseases and metabolism
- Cerebrospinal fluid and hydrocephalus
North Carolina State University
2016-2025
North Central State College
2020-2024
Veterinary Medical Center
2007
Texas A&M University
2004
The Schwarzman Animal Medical Center
2003
Harris Health System
2003
Cornell University
1997-2003
University of Parma
2001-2002
Colorado State University
1994-2002
New York State College of Veterinary Medicine
1997
Dogs with epilepsy are among the commonest neurological patients in veterinary practice and therefore have historically attracted much attention regard to definitions, clinical approach management. A number of classification proposals for canine been published during years reflecting always parts current coming from human organisation International League Against Epilepsy (ILAE). It has however not possible gain agreed consensus, "a common language", terminology used between neurologists...
This article outlines the consensus proposal on diagnosis of epilepsy in dogs by International Veterinary Epilepsy Task Force. The aim this is to improve consistency clinical and research settings. diagnostic approach patient presenting with a history suspected epileptic seizures incorporates two fundamental steps: establish if events animal demonstrating truly represent so, identify their underlying cause. Differentiation from other non-epileptic episodic paroxysmal can be challenging....
To determine long-term (> 6 months) outcome of dogs with paraplegia and loss hind limb deep pain perception (DPP) resulting from intervertebral disk herniation or trauma.Retrospective study.87 dogs.Outcome was determined as successful unsuccessful. The association neuroanatomic localization, breed, age, weight, sex, (for herniation) speed onset signs duration prior to surgery evaluated. Owners were contacted by telephone identify health problems.Nine 17 traumatic injuries treated, 2 regained...
This report represents a scientific and working clinical consensus statement on seizure management in dogs based current literature expertise. The goal was to establish guidelines for predetermined, concise, logical sequential approach chronic starting with identification diagnosis (not included this report), reviewing decision‐making, treatment strategies, focusing issues related antiepileptic drug response monitoring, enhance patient quality of life. Ultimately, we hope provide foundation...
Abstract Objective —To develop and compare the reliability of 2 methods scoring pelvic limb gait in dogs recovering from thoracolumbar spinal cord injuries to use this system determine rate level functional recovery with acute intervertebral disk herniations. Animals —46 resulting Procedure —Dogs' gaits were videotaped at different time intervals after injury. In phase 1 study, stages function identified, a numeric was devised reflect that recovery. 2, scored by observers, using visual...
To assess signalment, clinical signs, results of CSF analysis, treatment, and survival times in dogs with granulomatous meningoencephalomyelitis (GME) to identify factors associated survival.Retrospective study.Medical records 42 GME.Information on neurolocalization, presence focal or multifocal method time from onset signs death was retrieved medical each dog. Kaplan-Meier analysis used times. The Cox proportional hazards predictors survival.Females toy terrier breeds were predisposed GME....
Common criteria for the diagnosis of drug resistance and assessment outcome are needed urgently as a prerequisite standardized evaluation reporting individual therapeutic responses in canine epilepsy. Thus, we provide proposal definition partial success patients with This consensus statement also suggests list factors aspects outcome, which should be considered addition to impact on seizures. Moreover, these expert recommendations discuss determine validity informative value trial an patient...
Background Acute intervertebral disk herniation ( IVDH ) is a common cause of spinal cord injury in dogs and currently there no proven medical treatment to counter secondary effects. Use methylprednisolone sodium succinate MPSS or polyethylene glycol PEG as neuroprotectants advocated but controversial because neither has been tested placebo‐controlled, randomized, blinded trials dogs. Hypothesis Polyethylene will improve the outcome severe caused by compared placebo. Animals Client‐owned...
Chondrodystrophoid breeds of dog are prone to explosive herniation mineralized disc material into the thoracolumbar spinal canal. The resulting acute cord injury may represent an excellent spontaneous model traumatic injury. aims this study were quantify recovery dogs following herniations, evaluate external factors that influence recovery, and identify a group suitable for use in clinical trials on neuroprotective drugs. gait 88 with herniations was scored at time 2, 4, 12 weeks after...
Background There is little evidence‐based information available to guide treatment of refractory epilepsy in dogs. The antiepileptic drug levetiracetam (LEV) administered dogs, although its safety and efficacy are unknown. Objective To evaluate the LEV as adjunctive therapy for Animals Thirty‐four client‐owned dogs with idiopathic epilepsy. Methods Randomized, blinded trial involving resistant phenobarbital bromide. Dogs received (20 mg/kg PO q8h) or placebo 16 weeks, after a 4‐week washout...
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) regarded as an important diagnostic test to reach diagnosis idiopathic epilepsy. However, given that requires exclusion other differentials for seizures, parameters MRI examination should allow detection subtle lesions which may not be obvious with existing techniques. In addition, there are several epilepsy humans, example some focal cortical dysplasias, only apparent...
Background Experimental evidence shows benefit of rehabilitation after spinal cord injury (SCI) but there are limited objective data on the effect recovery dogs surgery for acute thoracolumbar intervertebral disc herniations (TL‐IVDH). Objective Compare basic and intensive post‐operative programs locomotion in with TL‐IVDH a randomized, blinded, prospective clinical trial. Animals Thirty non‐ambulatory paraparetic or paraplegic (with pain perception) decompressive TL‐IVDH. Methods Blinded,...
Abstract Background Intervertebral disc herniation (IVDH) is the most common spinal cord disease in dogs. Little information available regarding clinical presentation of nerve root signature (NRS) associated with cervical IVDH. Hypothesis/Objective To detail and magnetic resonance imaging (MRI) findings dogs NRS Animals Forty‐seven client‐owned presenting thoracic limb MRI confirmed Methods Medical records from 2010 to 2020 were retrospectively reviewed for that met inclusion criteria....
Abstract Background Post‐ictal (PI) clinical signs are a key defining stage of seizure manifestation in dogs. However, this phase remains poorly understood. Objectives To further characterize PI and their relation to other parts seizure, understand the owner's perception how affect quality life (QOL) dog. Animals Eight‐seven dogs with diagnosis idiopathic epilepsy from single institution. Methods The prospective questionnaire‐based study surveying owners previously newly diagnosed epilepsy....
ABSTRACT Background The bidirectional relationship between epilepsy and sleep is well characterized in humans but has not been thoroughly explored dogs. Objective Evaluate differences dogs with idiopathic healthy controls determine associations among characteristics, antiseizure medications (ASMs), sleep. Animals Sixty‐four 64 non‐epileptic control matched by age, breed, sex. Methods Owners of all completed an online survey that included questions regarding signalment, history if applicable,...
This case report describes a rare presentation of cerebral salt-wasting syndrome (CSW) in 10-week-old German Shorthaired Pointer following traumatic brain injury. The patient presented stuporous and tetraplegic with advanced imaging revealing depressed skull fracture active hemorrhage. Following surgical intervention, the dog exhibited persistent hypovolemia hyponatremia prompting treatment intravenous hypertonic saline enteral sodium supplementation. Positive response to supplementation,...
To evaluate the postoperative morbidity and long-term outcome of dogs after dorsal laminectomy for caudal cervical spondylomyelopathy (CCSM).Retrospective study.Twenty with CCSM.Medical records treated by CCSM at North Carolina State University Colorado between 1989 1999 were reviewed. Information on signalment, onset, progression duration clinical signs, diagnostic testing, sites laminectomy, complications, length hospitalization, ambulatory status discharge was recorded. A minimum...
To identify risk factors for episodes of status epilepticus (SE) in dogs with idiopathic epilepsy and determine how SE affects long-term outcome survival time.Retrospective study.32 epilepsy.Information on signalment, seizure onset, initiation treatment, anticonvulsants administered, number SE, overall control, was obtained from medical records through telephone interviews. Differences between that did not have were evaluated statistically.19 (59%) had 1 or more SE. Body weight the only...
Bartonella vinsonii (B. vinsonii) subspecies berkhoffii is a recently recognized cause of endocarditis, myocarditis, and granulomatous disease in dogs. In an effort to elucidate other potential manifestations, the case records 24 dogs that were seroreactive B. (berkhoffii) antigens studied retrospectively. Diagnoses included immune-mediated hemolytic anemia, neutrophilic or meningoencephalitis, polyarthritis, cutaneous vasculitis, uveitis. Repeated antibody titers became negative after...
To describe diagnostic findings, surgical technique, and outcome in dogs with thoracic spinal canal stenosis vertebral instability secondary to congenital anomalies.Retrospective clinical study.Dogs (n=9) stenosis.Medical records (1995-1996; 2000-2006) of 9 a myelographic diagnosis and/or anomaly that were surgically managed by stabilization or without laminectomy reviewed. Data on pre- postoperative neurologic status, techniques, outcomes retrieved. Follow-up evaluations performed at 1, 2,...