A5073789636- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Veterinary Oncology Research
- Veterinary Orthopedics and Neurology
- Veterinary Medicine and Surgery
- Viral gastroenteritis research and epidemiology
- Veterinary Practice and Education Studies
- Veterinary Equine Medical Research
- Congenital Anomalies and Fetal Surgery
- Human-Animal Interaction Studies
- Veterinary Pharmacology and Anesthesia
- Pediatric Hepatobiliary Diseases and Treatments
- Infectious Diseases and Mycology
- Urological Disorders and Treatments
- Knee injuries and reconstruction techniques
- Microbial infections and disease research
- Orthopedic Surgery and Rehabilitation
- Surgical Sutures and Adhesives
- Salivary Gland Tumors Diagnosis and Treatment
- Patient Safety and Medication Errors
- Herpesvirus Infections and Treatments
- Gastroesophageal reflux and treatments
- Abdominal Surgery and Complications
- Neonatal and fetal brain pathology
Willows Veterinary Centre and Referral Service
2019-2025
University of Bristol
2006-2024
Paragon (Greece)
2024
At Bristol
2008-2019
Royal Veterinary College
2006-2018
John Wiley & Sons (United States)
2018
Moss Landing Marine Laboratories
2018
Hudson Institute
2018
University of Hertfordshire
2011
University of Florida
2009
The domestic dog may be the most morphologically diverse terrestrial mammalian species known to man; pedigree dogs are artificially selected for extreme aesthetics dictated by formal Breed Standards, and breed-related disorders linked conformation ubiquitous diverse. Brachycephaly–foreshortening of facial skeleton–is a discrete mutation that has been in many popular breeds e.g. Bulldog, Pug, French Bulldog. A chronic, debilitating respiratory syndrome, whereby soft tissue blocks airways,...
Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with liver disease. The pathogenesis he incompletely understood although ammonia inflammatory cytokines have been implicated as key mediators. To facilitate further mechanistic understanding the HE, a large number animal models developed which often involve surgical creation anastomosis between hepatic portal vein caudal vena cava. One most common congenital abnormalities dogs portosystemic shunt (cpss),...
Abstract Mucosal melanoma is a rare subtype associated with poor prognosis and limited existing therapeutic interventions, in part due to lack of actionable targets translational animal models for preclinical trials. Comprehensive data on this tumour type are scarce, often overlooks the importance anatomical site origin. We evaluated human canine oronasal mucosal (OMM) determine whether common disease could inform equivalent. Using primary OMM cohort treatment‐naive archival tissue,...
In a survey of uk veterinary practitioners, 96 per cent indicated that they performed ovariohysterectomy on cats via flank laparatomy rather than midline coeliotomy. At teaching hospital 32 were spayed by the approach and 34 approach, undergraduate students under continuous supervision surgeon. The duration each part procedures was recorded information obtained from students, supervisors owners means questionnaires. total surgery students' assessment difficulty not significantly different...
To review aetiology, clinical signs and outcome of cats surgically treated for septic peritonitis (2000-2007).A retrospective study. Inclusion criteria were the identification intracellular bacteria degenerate neutrophils and/or a positive culture from abdominal fluid exploratory coeliotomy. Aetiology, signs, haematological biochemical parameters, surgical treatment recorded analysed.Twenty-six fulfilled inclusion criteria. Abdominal pain was reported in 10 (38 per cent) vomiting 11 (42...
To determine the incidence, outcome, and risk factors for postattenuation neurological signs (PANS) seizures after attenuation of single congenital portosystemic shunts (CPSS) in dogs.Retrospective cohort study.Dogs (N = 253) with CPSS.Medical records dogs treated by surgical a CPSS between February 2000 July 2015 were reviewed signalment preoperative postoperative clinical outcomes, including occurrence PANS. Univariable multivariable binary logistic regression was used to assess PANS...
Background Gall bladder mucoceles (GBM) are a leading cause of biliary disease in dogs with several breeds, including the Shetland Sheepdog, American Cocker Spaniel, Chihuahua, Pomeranian, and Miniature Schnauzer apparently predisposed. Objective To determine risk factors, clinical features, response to treatment GBM Border terriers (BT). Animals Medical records 99 (including 51 BT) an ultrasonographic (±histopathologic) diagnosis from three referral centers United Kingdom were collected. A...
The popularity of brachycephalic dogs continues to increase despite inherent breed health problems. Increased education current and potential dog owners could reduce the desirability severely affected dogs.Members general public were prospectively recruited assess their understanding opinions breed-related problems, before after an educational intervention on obstructive airway syndrome (BOAS).A total 587 people participated. Before most participants considered characteristics BOAS be normal...
To report the long-term bile acid stimulation test results for dogs that have undergone complete suture ligation of a single congenital extrahepatic portosystemic shunt.Data were collected from hospital records all had shunt. Owners invited to return referral centre or their local veterinarian repeat serum measurement. Dogs diagnosed with idiopathic epilepsy and undergoing tests used as comparison population.Fifty-one study included, mean follow-up time 62 months. 48 no evidence multiple...
To report the incidence of postattenuation seizures (PAS) in dogs that underwent single congenital extrahepatic portosystemic shunt (cEHPSS) attenuation and to compare PAS either did or not receive prophylactic treatment with levetiracetam (LEV).Multi-institutional retrospective study.Nine hundred forty dogs.Medical records were reviewed identify surgical a cEHPSS from January 2005 through July 2017 developed within 7 days postoperatively. Dogs divided into 3 groups: no LEV (LEV-); at ≥15...
To compare the outcomes of dogs treated at a single institution for extrahepatic congenital portosystemic shunts (CPSS) by thin film banding (TFB) or placement an ameroid constrictor (AC).Retrospective case series.Seventy-six client-owned with CPSS TFB (n = 53) AC 23).Records were reviewed signalment, preoperative, intraoperative, and postoperative management short-term outcomes. Data on second surgeries reviewed. Long-term obtained via owner-directed health-related quality life...
To investigate the use of computed tomography (CT) arthrography in cadaveric canine stifles with particular emphasis on diagnosis meniscal injury.Prospective cadaver study.Pelvic limbs from adult Beagles (n=10).After survey CT scan each stifle oriented dorsal plane, positive contrast arthrogram (CTA) was performed using same slice orientation. Each then randomly allocated into 1 2 treatment groups: group A--arthrotomy, cranial cruciate ligament (CCL) transection and simulated injury to...
The aim of this study was to investigate the short- and long-term morbidity mortality associated with urethral rupture in cats. Medical records were reviewed from four veterinary hospitals. Diagnosis made retrograde urethrography or direct visualisation during surgery. Location categorised as pre-, intra- post-pelvic. Follow-up data collected referring veterinarians. Sixty-three cats included which, males predominated (88.9%). Trauma most common cause (n = 35; 55.6%) remainder due iatrogenic...
Summary Objective: To report the use of a 4.5 mm shaft screw for management humeral condylar fractures (HCF) and incomplete ossification condyle (IOHC) in dogs, to assess risk factors complications. Methods: Dogs with HCF or IOHC that were managed minimum follow-up six months from surgery included. Data case records used identify Long-term was provided by an owner questionnaire veterinary re-examination. Results: Forty-three elbows treated 40 dogs (14 IOHC, 29 HCF). Minor complications seen...
O bjectives : To gather information to support the use of fluoroscopically guided removal tracheal foreign bodies in cats. It was also intent produce a case series and look at long‐term outcome following body removal. M ethods A retrospective study performed. This looked cases cats seen University Bristol veterinary school Langford over an eight‐year period. Outcome assessed via telephone conversations with owners. R esults Twelve were presented during this time. Ten these successfully...
O bjective : To assess the usefulness of computed tomography arthrography stifle in diagnosing meniscal tears dogs with cranial cruciate ligament insufficiency. M ethods A prospective clinical study was performed. Dogs were included if they had evidence insufficiency or persistent recurrent lameness following surgery for sedated a scan affected stifle, orientated dorsal plane. survey followed by arthrogram. arthrotomy performed, and surgical findings recorded. The scans reviewed three...
To investigate the frequency of airway injury and damage to other vital structures associated with cervical bite wounds in dogs cats implications for management outcome.A retrospective search electronic patient records was used identify suffering that were presented a large multidisciplinary veterinary hospital over four year period.Complete available 55 animals, one animal two separate injuries. Fourteen animals (25%) had injuries structures, including nine (17%) which surgically confirmed...
To design a health-related quality of life questionnaire for dogs with congenital portosystemic shunts, use it in cohort treated suture attenuation and compare results those obtained from healthy control cohort.Data were collected the hospital records ligation an intrahepatic or extrahepatic shunt at two referral centres. Owners asked to complete assessing their dog's preoperatively (retrospectively) time follow-up. also completed questionnaire.One hundred twenty-eight shunts 131 recruited....
Liver disease is a major cause of morbidity and mortality. One the most significant complications in patients with liver development neurological disturbances, termed hepatic encephalopathy. The pathogenesis encephalopathy incompletely understood, which has resulted wide range experimental models. Congenital portosystemic shunt one common congenital disorders diagnosed client owned dogs. Our recent studies have demonstrated that pathophysiology canine very similar to human encephalopathy,...
Abstract Objective To determine the incidence, outcome, and risk factors for postattenuation neurological signs (PANS) in cats treated single congenital portosystemic shunts (CPSS). Study design Retrospective cohort study. Animals Cats (n = 50) with a CPSS. Methods Medical records of by surgical attenuation CPSS between 2003 2017 were reviewed signalment, technique, preoperative management postoperative clinical outcomes. Binary logistic regression was performed to investigate occurrence...
A 11‐year‐old, female, spayed greyhound was presented with a haemorrhagic discharge from the vulva. Clinical examination, vaginoscopy and computed tomography scan showed an irregular egg‐sized mass in region of cervix uterine stump. An endoscopic grab biopsy (incisional) suggested malignant mesenchymal tumour. Following this, surgical excision cranial vagina, remnant performed. The final diagnosis haemangiosarcoma based on histological examination larger excisional specimen confirmed by...
The purpose of the study was to report postoperative outcome, complications, and long-term follow-up use a static hydraulic urethral sphincter for management mechanism incompetence in female dogs. Medical records were reviewed extract information on (>365 days) outcome data. Telephone owner questionnaire performed assess urinary continence scores (scale 1-10, where 10 is complete continence) presence frequency complications. Twenty dogs included. Mean (±standard deviation) time 1,205.1...