A5080241226- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Mast cells and histamine
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Lung Cancer Research Studies
- TGF-β signaling in diseases
- Urinary Tract Infections Management
- Sarcoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Microbial infections and disease research
- Drug-Induced Adverse Reactions
- Polyomavirus and related diseases
- Autoimmune Bullous Skin Diseases
University of Liverpool
2018-2025
Université de Toulouse
2017
École Nationale Vétérinaire de Toulouse
2017
Erythema multiforme is a rare immune-mediated cutaneous disorder. Canine erythema (EM) can occur secondarily to triggers such as drugs, food and infections but more commonly considered idiopathic. In humans, paraneoplastic origin also described whereas EM has only been reported in one dog with thymoma. This case report the first description of concurrently diagnosed low-grade small-cell T-cell intestinal lymphoma, raising suspicion syndrome. A 9-year-old, neutered male, crossbred dog, no...
Abstract Mucosal melanoma is a rare subtype associated with poor prognosis and limited existing therapeutic interventions, in part due to lack of actionable targets translational animal models for preclinical trials. Comprehensive data on this tumour type are scarce, often overlooks the importance anatomical site origin. We evaluated human canine oronasal mucosal (OMM) determine whether common disease could inform equivalent. Using primary OMM cohort treatment‐naive archival tissue,...
The standard of care treatment for canine lymphoma is multi‐agent chemotherapy containing prednisolone, cyclophosphamide, vincristine and an anthracycline such as doxorubicin (CHOP) or epirubicin (CEOP). Lomustine, vincristine, procarbazine, prednisone (LOPP) has been evaluated a rescue, with encouraging results; however, resistance to likely in patients relapsing on CHOP/CEOP, this agent may enhance LOPP toxicity without improving efficacy. aim study was evaluate responses modified‐LOPP...
The staging system commonly used in canine anal sac gland carcinoma (ASGC) is a revised Tumour-Node-Metastasis (TNM) published 2007. This consists four stages and, for dogs with nodal metastases, the size of metastatic lymph node (mLN) defines N stage. However, we hypothesise that (1) mLN has no prognostic significance when can be excised, (2) high number mLNs associated poorer prognosis and (3) measurement on imaging not reproducible. To investigate these hypotheses, medical records...
Neoadjuvant chemotherapy can be used in canine mast cell tumours (MCTs) to optimise surgical margins or enable marginal excision challenging locations. The objective of this study was describe the outcome dogs with cutaneous and subcutaneous MCTs treated neoadjuvant vinblastine-prednisolone (NA-VP). Records treatment-naïve cutaneous/subcutaneous MCT that received NA-VP were reviewed including signalment, indication for NA-VP, staging results, clinical response, data histopathology reports....
The DMAC protocol (dexamethasone, melphalan, actinomycin-D, cytarabine) has been evaluated in American studies for the treatment of relapsed canine lymphoma, comparing similarly to other rescue protocols. aim this study was evaluate efficacy and toxicity DMAC, a larger UK cohort resistant lymphomas. Medical records dogs with non-Hodgkin high-grade lymphomas that received as were reviewed from 2007 2017. Response, time initiation discontinuation (TTD) (Veterinary Cooperative Oncology Group...
Objectives The aims of this study were to describe the clinical presentation, tumour characteristics, responses chemotherapy protocols and toxicity in a cohort cats with lymphoma up 18 months age. In addition, probability long‐term (>2 years) survival was explored. Materials Methods medical records client‐owned aged diagnosed between 2008 2022 at five UK‐based veterinary referral hospitals reviewed. Results Thirty‐three included. most common anatomical forms mediastinal (42%),...
Abstract Mucosal melanoma is a rare subtype associated with poor prognosis and limited existing therapeutic interventions, in part due to lack of actionable targets translational animal models for pre-clinical trials. Comprehensive data on this tumour type scarce, often overlooks the importance anatomical site origin. We evaluated human canine oronasal mucosal determine whether common disease could inform equivalent. Using primary (OMM) cohort treatment naive archival tissue, alongside...
Abstract Canine cutaneous mastocytosis (CM) is rare in contrast to canine mast cell tumours. In humans, CM commonly affects children and usually indolent with possible spontaneous resolution. Systemic (SM) bone marrow involvement typically adults, can have a poor outcome, often includes skin lesions. ‘Mastocytosis the skin’ (MIS) preferred term of lesions, if evaluations are not available, which cases dogs. human SM CM, KIT mutations detected. The veterinary literature suggests clinical...
Hematological indices play a prognostic role in human osteosarcoma (OSA), but data are limited dogs. The aim of this retrospective multicentric cohort study was to investigate the significance pre-operative hematological/inflammatory client-owned dogs with appendicular OSA receiving standardized treatment. Cut-offs associated progression-free survival (PFS) for hematological values/ratios were established using minimal p-value approach. Historical factors also assessed. Statistical analyses...
Mast cell tumours (MCTs) are commonly treated with radiation therapy, most often in a microscopic disease setting. Poorer outcomes expected patients gross disease, and irradiation of may be associated greater toxicity. The aim this study was to compare acute adverse events (AE) dogs MCTs receiving radiotherapy. Fifty‐seven were included, 28 29 microscopic. In order assess mucosal skin toxicity, assigned 2 groups: head (29 patients, 14 15 microscopic) other sites (28 each). All external beam...