A5076705484- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Virus-based gene therapy research
- Oral and Maxillofacial Pathology
- Microbial infections and disease research
- Mast cells and histamine
- Tumors and Oncological Cases
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Veterinary Medicine and Surgery
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Polyamine Metabolism and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- Cancer and Skin Lesions
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Pancreatic function and diabetes
- Bone Tumor Diagnosis and Treatments
- Coccidia and coccidiosis research
- Cancer, Stress, Anesthesia, and Immune Response
University of Liverpool
2014-2024
University of Bari Aldo Moro
2010-2023
University of Zurich
2015
University of Pisa
2009-2015
Clinica Mediterranea
2009-2010
Istituto Nazionale di Fisica Nucleare, Sezione di Pisa
2010
To compare the Kiupel (2 categories) and Patnaik (3 histologic grading systems for predicting presence of metastasis at time initial examination in dogs with cutaneous mast cell tumors (MCTs).Retrospective case series.386 client-owned MCTs.Medical records newly diagnosed, histologically confirmed MCTs that had undergone complete clinical staging were reviewed histopathologic data.All grade 1 (n = 52) classified as low-grade MCTs, all 3 (43) high-grade MCTs. Of 291 2 243 (83.5%) tumors, 48...
To describe clinical characteristics, treatment, and outcome of dogs with inflammatory carcinoma (IC) identify patient-, tumor-, treatment-related factors associated overall survival time.Retrospective case series.43 client-owned dogs.Records a diagnosis IC that had histologic evidence dermal lymphatic invasion were reviewed. Data on staging, toxicoses, response, time retrieved. Results-26 (60%) primary 17 (40%) secondary IC. Thirty-five (81%) distant metastases 2 (5%) local at the initial...
The prevalence of gastrointestinal parasites was investigated in mammals housed two the main Italian zoological gardens: Zoo Safari Fasano (province Bindisi, Apulia, Italy) and Giardino Zoologico Pistoia (Tuscany, Italy). In November 2007, fecal samples were collected at (n = 96) 60), from primates, carnivores, perissodactyls, artiodactyls proboscideans. most cases, same animal species or genera considered both zoos. One more intestinal detected 61.5% examined samples. However, very...
Abstract Lymph node (LN) metastasis is a negative prognostic factor in dogs with cutaneous mast cell tumours (cMCTs). While elective lymphadenectomy of metastatic LNs improves outcome, the benefit adjuvant medical therapy early (HN2) debated. The aim this retrospective multicentre study was to evaluate therapeutic following surgical removal primary low‐grade cMCT (Patnaik grade 1‐2 and Kiupel low‐grade) HN2 by analysing survival rates patterns recurrence. Seventy‐three were included: 42...
Historically, the prognosis for dogs with stage II Kiupel high-grade cutaneous mast cell tumours has been considered poor.The aim of this study was to explore impact lymphadenectomy on outcome in and overt regional lymph node metastasis.Data from completely staged and/or certain metastasis undergoing excision primary adjuvant medical treatment were extracted. Dogs a cytological diagnosis that did not undergo compared underwent had histological metastasis.Forty-nine included, 18 while 31...
Canine breeds may be considered good animal models for the study of genetic predisposition to cancer, as they represent clusters. From epidemiologic and case collection studies it emerges that some are more likely develop lymphoma or specific subtypes but available data variable geographically inconsistent. This was born in context European Lymphoma Network with aim investigating breed prevalence canine different countries possible risk overall and/or subtypes. A total 1529 nodal cases...
Primary uterine lymphoma is an extremely rare disease. An 11‐year‐old spayed female domestic short‐haired cat presented with a 3‐month history of mucopurulent vaginal discharge, lethargy, acute vomiting and constipation. Physical examination revealed vulvar swelling, purulent discharge mass in the mid‐caudal abdomen. A CT scan identified large mass, displacing colon dorsally urethra ventrally. hysterectomy was performed. Histology immunohistochemistry confirmed T‐cell transmural medium to...
Objectives The aims of this study were to evaluate the response rate, time progression (TTP) and survival times dogs with high‐risk adrenal gland tumours (ATs) treated toceranib phosphate, in both macroscopic microscopic setting, report adverse event (AE) profiles. Materials Methods Medical records diagnosed a adrenocortical carcinoma (ACC) or phaeochromocytoma (PCC), toceranib, retrospectively reviewed. High‐risk ATs defined as inoperable and/or metastatic cortical high Utrecht score....
ABSTRACT Histiocytic sarcoma (HS) is a highly metastatic cancer, and while response to several chemotherapy agents has been studied, the outcome remains poor. Vinorelbine (VNB) considered possible treatment option, but data are limited. The aim of this study was assess efficacy toxicity VNB in canine HS. Medical records dogs with HS, treated as first‐line or rescue treatment, were reviewed. Overall rate (ORR), progression‐free survival (PFS), overall post‐VNB (post.VNB.OST) adverse events...
Haemangiosarcoma (HSA) has an aggressive biological behaviour and carries a poor prognosis, with less than 10% of treated dogs surviving longer 1 year. In this retrospective study varied metronomic chemotherapy (MC) regimen preceded by adjuvant doxorubicin-based maximum-tolerated dose (MTDC) was compared MTDC, in terms efficacy [time to metastasis, (TTM) survival time (ST)] safety biologically HSA. Dogs were eligible if they had no metastasis after MTDC received either further or MC...
Abstract Canine hemangiosarcoma (HSA) is a neoplasm of vascular endothelial origin that has an aggressive biological behaviour, with less than 10% dogs alive at 12‐months postdiagnosis. Treatment choice consists surgery followed by adjuvant doxorubicin‐based chemotherapy. We prospectively compared doxorubicin and dacarbazine ( ADTIC ) to traditional cyclophosphamide AC treatment, aiming determining safety assessing whether this regimen prolongs survival time metastasis TTM ). Twenty‐seven...
Feline large granular lymphocyte ( LGL ) lymphoma is an uncommon subtype of characterized by a grave prognosis and scarce response to chemotherapy. There are limited reports on clinico‐pathological prognostic factors. One‐hundred 9 cats with newly diagnosed that underwent initial staging (including hematology, serum biochemistry, thoracic radiographs abdominal ultrasound), followed‐up were retrospectively evaluated. was localized within the gastrointestinal tract or without extra‐intestinal...
Unresectable or metastatic (advanced) primary pulmonary carcinoma (PPC) represents a therapeutic challenge where surgery may be contraindicated and the role of maximum-tolerated dose (MTD) chemotherapy remains uncertain. This study was undertaken to explore impact metronomic (MC) in dogs with advanced PPC. Previously untreated (T3 N1 M1) PPC, complete staging work-up follow-up data, receiving MC (comprising low-dose cyclophosphamide, piroxicam thalidomide), surgery, MTD no oncologic...
Treatment options for dogs with metastatic (stage III) splenic hemangiosarcoma are limited. A doxorubicin-based chemotherapy regimen is commonly administered; however, there no published data to support this practice. The aim of study was investigate the impact maximum-tolerated-dose (MTD), metronomic (MC) and adjuvant treatment on outcome in stage III undergoing splenectomy. Medical records that underwent splenectomy followed by MTD chemotherapy, MC or were retrieved. Time progression...
Lactate dehydrogenase (LDH) is commonly used in human cancer patients for prognostic purposes. Aim of this study was to determine the magnitude serum LDH elevation dogs with compared healthy and non-neoplastic disease, verify whether it may support diagnosis specific malignancies. About 128 dogs, 211 diseased 188 were enrolled. Dogs had significantly higher than (P < 0.001) 0.001), but large overlap found. lymphoma showed carcinoma or mast cell tumour (MCT; P 0.05) not other When considering...
Splenectomy followed by adjuvant chemotherapy is commonly used to treat canine splenic haemangiosarcoma (HSA), although it unclear if different treatment protocols may have a similar efficacy. The objective of this retrospective study was assess outcome in dogs with stage I and II HSA treated either first-line anthracycline (AC) or metronomic (MC)-based protocols, comparing median time progression (TTP) survival (MST). Medical records nine institutions were searched for diagnosed that...
Abstract Objective —To evaluate whether serial determinations of serum lactate dehydrogenase (LDH) activity in dogs with lymphoma could be used to predict outcome and assist early recognition disease progression. Design —Prospective cohort study. Animals —50 lymphoma. Procedures —LDH was determined newly diagnosed or that had not received treatment. The LDH measured at time initial diagnosis, completion chemotherapy, 1, 3, 6 months after chemotherapy. Treatment response recurrence were...
Abstract Background While lymphadenectomy of metastatic lymph nodes (LNs) has been associated with improved outcome, the clinical utility prophylactic in dogs stage I cutaneous mast cell tumors (cMCTs) remains a controversial topic. To assess therapeutic role uninvolved regional LNs, long-term outcome cMCT-bearing cytologically negative and surgically unresected LNs (observation only, OO) was compared that resected histologically (prophylactic lymphadenectomy, PRL). Results A retrospective...
Localized histiocytic sarcoma may occur as a primary lesion in periarticular tissues of large appendicular joints. Treatment options for the include radical surgical excision, radiation therapy (RT), or both, combination with chemotherapy potential systemic metastases. In an effort to better characterize time progression (TTP) following vs non-surgical approaches (PAHS), contemporary European population affected dogs was retrospectively surveyed. Medical records were queried newly-diagnosed...
Abstract Oxidative stress status has been evaluated in depth human medicine and its role carcinogenesis clearly established. The purpose of this prospective study was to evaluate antioxidant concentrations oxidative dogs with mast cell tumours ( MCTs ) that had received no previous treatments, compare them healthy controls. In 23 tumour 10 controls, assessed using the Reactive Oxygen Metabolites‐derived compounds (d‐ ROMs test, activity measured by Biological Antioxidant Potential BAP...
Abstract Carcinomatosis and sarcomatosis describe the widespread dissemination of metastatic neoplastic cells throughout body. Studies describing their clinical imaging features in veterinary patients are limited. The objective this retrospective, multicenter, cross‐sectional study is to clinical, ultrasonographic, CT pleural peritoneal carcinomatosis dogs cats aid detection differentiation these lesions. Medical records ultrasonographic images were reviewed. Although a large degree overlap...
The aims of this study were to report treatment outcomes for dogs with histiocytic sarcoma (HS) treated both lomustine and epirubicin, response rates epirubicin as a rescue therapy in previously lomustine. Medical records diagnosis HS that retrospectively evaluated. Of 29 receiving alternating with, or subsequent treatment, including setting, could be assessed 20 an overall rate (ORR) 29% biological (BRR) 71%. Median time progression (TTP) 12 these which it was assessable 69 days (range:...
The standard of care treatment for canine lymphoma is multi‐agent chemotherapy containing prednisolone, cyclophosphamide, vincristine and an anthracycline such as doxorubicin (CHOP) or epirubicin (CEOP). Lomustine, vincristine, procarbazine, prednisone (LOPP) has been evaluated a rescue, with encouraging results; however, resistance to likely in patients relapsing on CHOP/CEOP, this agent may enhance LOPP toxicity without improving efficacy. aim study was evaluate responses modified‐LOPP...