A5037511525- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Oral and Maxillofacial Pathology
- Tumors and Oncological Cases
- Sarcoma Diagnosis and Treatment
- Virus-based gene therapy research
- Microbial infections and disease research
- Animal Behavior and Reproduction
- Salivary Gland Tumors Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Hedgehog Signaling Pathway Studies
- Veterinary Orthopedics and Neurology
- Laser Applications in Dentistry and Medicine
- Soft tissue tumor case studies
- Wound Healing and Treatments
- Surgical Sutures and Adhesives
- Immunotherapy and Immune Responses
- Platelet Disorders and Treatments
- Avian ecology and behavior
- Ear and Head Tumors
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Bird parasitology and diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related molecular mechanisms research
University of Milan
2015-2024
Kingston General Hospital
1995
Queen's University
1993-1995
To compare the Kiupel (2 categories) and Patnaik (3 histologic grading systems for predicting presence of metastasis at time initial examination in dogs with cutaneous mast cell tumors (MCTs).Retrospective case series.386 client-owned MCTs.Medical records newly diagnosed, histologically confirmed MCTs that had undergone complete clinical staging were reviewed histopathologic data.All grade 1 (n = 52) classified as low-grade MCTs, all 3 (43) high-grade MCTs. Of 291 2 243 (83.5%) tumors, 48...
Metastasis to regional lymph nodes (RLNs) in dogs with cutaneous mast cell tumour (cMCT) has been correlated shortened survival time and higher risk of spread distant sites. In the present study, extirpation non-palpable or normal-sized RLNs was included surgical management cMCT dogs. Correlations between histological nodal status (HN0-3) variables were analysed. Ninety-three single without metastasis that underwent wide excision primary RLN included. The association HN (HN0 vs > 0; HN0-1...
Lymph node (LN) metastasis in canine cutaneous mast cell tumours (cMCTs) is a well-known negative prognostic factor. The role of lymphadenectomy the treatment stage II disease remains controversial because its uncertain therapeutic benefit. Aim this retrospective study was to investigate impact on tumour control and survival for dogs with cMCTs. Dogs firstly occurring, histologically confirmed cMCT LN undergoing resection primary medical thereafter were retrospectively enrolled. classified...
Vertebrates have an immature immune system soon after birth, and parasites can therefore be particularly virulent to young hosts. Transfer of factors via the egg give rise early maternal effects with important consequences for offspring fitness, as maternally derived immunity confers anti-parasite protection. Mothers are expected allocate differentially eggs according reproductive value their influenced by quality father. In this study, we analysed transmission yolk antibodies specific...
Summary Egg size and composition can be predicted to trade‐off against current condition of reproducing females. Adverse conditions for reproduction should thus give rise a reduction in egg quality. Here we analyse timing reproduction, mass hatchability, concentration maternal carotenoids components the immune system eggs relation ambient temperature during breeding season Barn Swallow ( Hirundo rustica , Linnaeus). Relatively high temperatures one day enhanced probability that clutches were...
Abstract Lymph node (LN) metastasis is a negative prognostic factor in dogs with cutaneous mast cell tumours (cMCTs). While elective lymphadenectomy of metastatic LNs improves outcome, the benefit adjuvant medical therapy early (HN2) debated. The aim this retrospective multicentre study was to evaluate therapeutic following surgical removal primary low‐grade cMCT (Patnaik grade 1‐2 and Kiupel low‐grade) HN2 by analysing survival rates patterns recurrence. Seventy‐three were included: 42...
Abstract Mothers influence their offspring phenotype by varying egg quality. Such maternal effects may be mediated transmission of antibodies and antioxidants. should adjust allocation substances depending on embryonic sex because differences in reproductive value, potentially dependent paternal genetic as reflected secondary sexual characters. We manipulated attractiveness male barn swallows (Hirundo rustica) investigated investment eggs relation to sex. allocated more against a pathogen...
Abstract Objective To report the outcomes associated with sentinel lymph nodes (SLN) detection and extirpation guided by radionuclide methylene blue injections in dogs cutaneous subcutaneous mast cell tumors (MCT). Study design Clinical prospective cohort study. Animals Thirty client‐owned MCT amenable to wide‐margin excision, without evidence of distant metastasis abnormal regional (RLN). Methods Technetium‐99 m were injected peritumorally. Dogs underwent preoperative γ‐camera scintigraphy...
Abstract Background The therapeutic role and prognostic relevance of lymphadenectomy in mast cell tumor (MCT) has historically been evaluated on regional rather than sentinel lymph nodes. Hypothesis/Objectives To update information about the association histological nodal (HN) classes with clinical outcome dogs MCT after excision extirpation normal‐sized nodes (SLN) guided by radiopharmaceutical. Animals Ninety‐four histologically‐confirmed treatment‐ naïve (71 cutaneous, 22 subcutaneous 1...
Introduction Canine soft tissue sarcomas (STSs) are locally aggressive mesenchymal tumors with variable recurrence rates, and often, their therapy is limited to surgical excision. CD117 (KIT) a tyrosine kinase receptor involved in cell growth cancer development. c-kit proto-oncogene mutations have been reported be associated prognosis response human canine cancers. However, expression rarely investigated STSs. This study aims assess different Methods Spontaneous STSs were surgically removed,...
Performance of animals may decline with age. The effects senescence, however, differ between the sexes because differences in physiology and behaviour. Acquired immunity provides hosts efficient mechanisms anti-parasite defence, but effect senescence on immunocompetence has never been studied natural populations. In barn swallow (Hirundo rustica), primary antibody response to an antigen during one breeding season declined age females, while secondary following both sexes. Parasite-mediated...
In diverse animal taxa, egg mass variation mediates maternal effects with long-term consequences for offspring ontogeny and fitness. Patterns of laying order differ considerably among birds, but no study has experimentally investigated the function in albumen or yolk content wild. barn swallows (Hirundo rustica), absolute relative increased order. Experimental removal delayed hatching, had larger negative on growth late-hatched nestlings, reduced nestling survival. Laying positively...
Background Canine cutaneous perivascular wall tumors (c‐ PWT ) are soft tissue sarcomas recently identified when hemangiopericytomas were reclassified. No previous clinical data available for c‐ . Hypothesis/Objectives To define the behavior and prognostic role of pathological variables in a homogeneous population Animals Fifty‐five c‐PWT 53 client‐owned dogs at first presentation undergoing surgery. Methods Retrospective case series. The endpoint was relapse tumor (local and/or distant)....
Canine perivascular wall tumors (cPWTs) arise from vascular mural cells and are included among soft tissue sarcomas (STSs). Most prognostic studies performed on canine STSs as a general group regardless of their specific histotype. The aim this study was to identify pathological parameters profiles with impact for cutaneous/subcutaneous cPWTs. Anatomical location, type growth, surgical margins, size depth the tumor were collected in 56 association between each pair variables evaluated by...
Background Distant metastases in dogs with cutaneous mast cell tumors (cMCT) are rare and incurable. The aims of this prospective study were to clarify the clinico‐pathological features stage IV cMCTs identify possible prognostic factors for progression‐free interval (PFI) survival time (ST). Material methods Dogs eligible recruitment if they had a previously untreated, histologically confirmed cMCT underwent complete staging demonstrating disease. uniformly followed‐up, whereas treatment...
Haemangiosarcoma (HSA) has an aggressive biological behaviour and carries a poor prognosis, with less than 10% of treated dogs surviving longer 1 year. In this retrospective study varied metronomic chemotherapy (MC) regimen preceded by adjuvant doxorubicin-based maximum-tolerated dose (MTDC) was compared MTDC, in terms efficacy [time to metastasis, (TTM) survival time (ST)] safety biologically HSA. Dogs were eligible if they had no metastasis after MTDC received either further or MC...
<h3>Background</h3> Pet dogs spontaneously develop lymphoma. An anthracycline-based multidrug chemotherapy regimen represents the treatment cornerstone; however, cure is rarely achieved. We have been treating with B-cell lymphoma an autologous vaccine (APAVAC®) and CHOP-based since 2011. <h3>Methods</h3> To better characterize safety efficacy of APAVAC®, to find best candidates for immunotherapy, we designed a retrospective study on all treated chemo-immunotherapy date compared them those...
Cutaneous and subcutaneous mast cell tumors (MCTs) are common canine neoplasms characterized by variable biological behavior. Tumor-associated macrophages (TAMs) tumor-infiltrating lymphocytes (TILs) can be effective prognostic markers in numerous human increasingly investigated dogs. The aim of this study was to characterize immune cells MCTs their relationship with histological location (cutaneous, subcutaneous) histologic nodal metastatic status (HN0-3). Thirty-eight (26 cutaneous, 12...
Feline injection-site sarcoma (FISS) may be a consequence of subcutaneous injection. In the present study, medical records and computed tomography (CT) features 22 cats with FISS, histopathological subtype fibrosarcoma, were used. The majority fibrosarcomas (45%) located in interscapular region. All fibrosarcomas, except one mild enhancement, showed strong contrast uptake, characterised as ring (42%), heterogeneous (36%), homogeneous (9%), heterogeneous/ring (6.5%) or mixed...
The recent literature supports the sentinel lymph node (SLN) biopsy in dogs with MCT due to discrepancy regional and high percentage of occult metastasis. However, SLN includes additional anesthesiologic, diagnostic, surgical procedures, costs. study aimed assess association between clinicopathological variables status, determining identification at lower risk metastases. Dogs integumentary were admitted lymphoscintigraphic mapping subsequent SLN. status was statistically tested, both...
Sentinel lymph node (SLN) mapping is the current gold standard for oncological staging of solid malignancies in humans. This prospective observational study describes feasibility and limits preoperative lymphoscintigraphy SLN detection dogs with spontaneous improvements accuracy. Client-owned confirmed malignant neoplasia absence distant metastasis were prospectively enrolled. Lymphoscintigraphy was performed after peritumoral injection Technetium-99m labeled nanocolloids. Regional dynamic...
Local recurrence (LR) is the major concern in treatment of feline injection-site sarcoma (FISS). Pretreatment leukocyte counts and ratios have been reported as diagnostic and/or prognostic markers human canine oncology. The aim this retrospective study was to explore impact on LR overall survival time (OST) pretreatment neutrophil-to-lymphocyte ratio (NLR), white blood cell count (WBCC), neutrophil (NC) lymphocyte (LC) cats with surgically excised FISS. Eighty-two histologically confirmed...
Small extracellular vesicles (sEV) are a class of (30–150 nm), delivering molecules including proteins, metabolites, and microRNAs (miRNAs), involved in physiological intercellular crosstalk disease pathogenesis. The present pilot study aims (I) to develop an easy fast protocol for the isolation sEV from plasma mast cell tumor (MCT)-affected dogs; (II) evaluate if miR-21-5p (sEV-miR-21-5p), miRNA overexpressed by MCT, is associated with sEV. Seventeen dogs have been enrolled study: 4 healthy...