A5063583733- Breast Cancer Treatment Studies
- Systemic Sclerosis and Related Diseases
- Gene expression and cancer classification
- Statistical Methods and Inference
- Veterinary Oncology Research
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Dermatologic Treatments and Research
- HER2/EGFR in Cancer Research
- Statistical Methods in Clinical Trials
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Venous Thromboembolism Diagnosis and Management
- Bioinformatics and Genomic Networks
- Oral and Maxillofacial Pathology
- COVID-19 Clinical Research Studies
- Tumors and Oncological Cases
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Sarcoma Diagnosis and Treatment
- COVID-19 epidemiological studies
- Acute Myocardial Infarction Research
University of Milan
2015-2024
Luigi Sacco Hospital
2022-2024
University of Chieti-Pescara
2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020-2021
Lombardia Informatica (Italy)
2020-2021
Regione Lombardia
2020-2021
Azienda Ospedaliera di Desio e Vimercate
2020
Fondazione IRCCS Istituto Nazionale dei Tumori
1995-2019
Veria General Hospital
2017
National Academies of Sciences, Engineering, and Medicine
2015
Background: The clinical outcome is generally positive for patients with node-negative breast carcinoma (i.e., those who do not have detectable metastases in the lymph nodes) been treated surgery or plus radiation therapy. In about 30% of patients, however, disease recurs, and they are at risk death. Determination valid new prognostic indicators would improve ability to identify high recurrence. Breast cancer can entail substantial development blood vessels within tumor tissue, it known that...
PURPOSE To determine the absolute and relative value of microvessel density (MVD), p53 c-erbB-2 protein expression, peritumoral lymphatic vessel invasion (PLVI), conventional prognosticators in predicting relapse-free (RFS) overall survival (OS) rates patients with node-negative breast carcinoma (NNBC). PATIENTS AND METHODS We monitored 254 consecutive NNBC for a median 62 months. Intratumoral MVD was measured after microvessels were immunostained using anti-CD31 antibody. hormone receptors...
Journal Article The Bcl-2 Protein: a Prognostic Indicator Strongly Related to p53 Protein in Lymph Node-Negative Breast Cancer Patients Get access Rosella Silvestrini, Silvestrini Search for other works by this author on: Oxford Academic PubMed Google Scholar Silvia Veneroni, Veneroni Maria Grazia Daidone, Daidone Elvira Benini, Benini Patrizia Boracchi, Boracchi Maura Mezzetti, Mezzetti Giovanni Di Fronzo, Fronzo Franco Rilke, Rilke Umberto Veronesi JNCI: of the National Institute, Volume...
Trop-2 is a calcium signal transducer that drives tumor growth. Anti-Trop-2 antibodies with selective reactivity versus maturation stages allowed to identify two different pools of Trop-2, one localized in the cell membrane and cytoplasm. Of note, membrane-localized/functional was found be differentially associated determinants aggressiveness distinct breast cancer subgroups. These findings candidated states having an impact on progression. We tested this model cancer. A large, consecutive...
Abstract Squamous‐cell carcinoma of the head and neck includes a heterogeneous group tumours upper air food passages for which prognosis is difficult to assess. In fact, patients in comparable stages may have diverse clinical courses responses similar treatments. order better define each patient there therefore need identify novel biological markers reflect more accurately growth rate, progression metastatic potential tumour. We assessed whether metastases correlate with micro‐vessel counts...
To evaluate the effect of adjuvant chemotherapy in patients with local-regional nasopharyngeal carcinoma (NPC) (squamous or undifferentiated) complete remission at end curative radiotherapy (RT) 229 were randomized from 1979 to 1983 a multicenter study no further therapy (116 patients) combination vincristine, cyclophosphamide, and Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH) (VCA) for six monthly cycles (113 patients). The RT + VCA groups well balanced median age (50 v 49...
To derive models suitable for outcome prediction, a crucial aspect is the availability of appropriate measures predictive accuracy, which have to be usable general class models. The Harrell's C discrimination index an extension area under ROC curve case censored survival data, owns straightforward interpretability. For model including covariates with time-dependent effects and/or covariates, original definition would require prediction individual failure times, not generally addressed in...
PURPOSE: Because interferon gave promising results in the management of metastatic renal cell carcinoma 1980s, a multicentric randomized controlled trial was planned to compare adjuvant recombinant alfa-2b (rIFNα2b) with observation after radical nephrectomy patients Robson stages II and III carcinoma. Overall event-free survival were be evaluated together prognostic factors. PATIENTS AND METHODS: curves for 247 (124 controls 123 treated) estimated by Kaplan-Meier method compared using...
Flexible modelling in survival analysis can be useful both for exploratory and predictive purposes. Feed forward neural networks were recently considered flexible non-linear of censored data through the generalization discrete continuous time models. We show that by treating interval as an input variable a standard feed network with logistic activation entropy error function, it is possible to estimate smoothed hazards conditional probabilities failure. easily implementable approach fast...
At present, most decisions concerning the use of adjuvant therapy in lymph node-negative breast cancer patients are made on basis traditional factors such as tumor size, nodal status, and histopathologic features. However, prognostic being investigated that could identify high-risk groups better address treatment efforts for those patients. Identification more accurate markers, expression mutant p53 protein encoded by (also known TP53) suppressor gene, reproducible, easily assessable,...
In Brief Summary Background Data: Axillary dissection, an invasive procedure that may adversely affect quality of life, used to obtain prognostic information in breast cancer, is being supplanted by sentinel node biopsy. older women with early cancer and no palpable axillary nodes, it be safe give treatment. We addressed this issue a randomized trial comparing dissection patients T1N0 cancer. Methods: From 1996 2000, 219 women, 65 80 years age, clinically negative nodes were conservative...
To assess the role of axillary dissection in older breast cancer patients with a clinically clear axilla.Axillary dissection, once standard treatment for cancer, is associated considerable morbidity. It has been substituted by sentinel node biopsy only if positive. We aimed to determine whether surgery can be omitted women, thereby sparing them morbidity, without compromising long-term disease control.We carried out randomized clinical trial on 238 (65-80 years) patients, N0 radiographic...
PURPOSE: There is considerable interest in biologic markers able to predict the response of cancer patients therapy. HER2 overexpression a potential indicator responsiveness doxorubicin and paclitaxel unresponsiveness tamoxifen breast carcinoma patients. However, significance cyclophosphamide, methotrexate, fluorouracil (CMF) has remained unclear. In this study, we investigated issue 386 first CMF controlled clinical trial with 20-year follow-up. PATIENTS AND METHODS: Node-positive were...
Experimental studies suggest that angiogenesis plays an important role in the pathogenesis of ascites and progression ovarian cancer. To evaluate association intratumoral microvessel density (IMD) with conventional clinicopathologic features to determine capability these factors predicting responsiveness platinum-based chemotherapy overall survival (OS) we studied 112 carcinomas. IMD was determined using anti-CD31 antibody immunocytochemistry. In entire series, correlated other features....
Abstract Objective To construct a prognostic index based on nailfold capillaroscopic examinations that is capable of predicting the 5‐year transition from isolated Raynaud's phenomenon (RP) to RP secondary scleroderma spectrum disorders (SSDs). Methods The study involved 104 consecutive adult patients with clinical history RP, and was externally validated in another cohort 100 same characteristics. Both groups were followed up for 1–8 years. Six variables examined because their potential...
Objective. A simple weighted prognostic algorithm, based on capillaroscopy and autoantibodies, is developed to classify patients at different risk of transition from isolated RP SSc within 5 years the screening visit. Methods. Two hundred eighty-eight 768 with who underwent were recruited. The contributions capillaroscopic findings (giant loops, haemorrhages number capillaries) SSc-associated autoantibodies (ACAs, anti-topo I ANAs) assessed in a semi-parametric regression models suitable for...
AimsTo assess different aspects of the definition valvular/non-valvular atrial fibrillation (AF) used in clinical practice by physicians who usually treat this condition.
Metastasis to regional lymph nodes (RLNs) in dogs with cutaneous mast cell tumour (cMCT) has been correlated shortened survival time and higher risk of spread distant sites. In the present study, extirpation non-palpable or normal-sized RLNs was included surgical management cMCT dogs. Correlations between histological nodal status (HN0-3) variables were analysed. Ninety-three single without metastasis that underwent wide excision primary RLN included. The association HN (HN0 vs > 0; HN0-1...