A5081406568- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Bone health and treatments
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Myasthenia Gravis and Thymoma
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Nutrition, Genetics, and Disease
- Genetic factors in colorectal cancer
- Tannin, Tannase and Anticancer Activities
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- RNA and protein synthesis mechanisms
- Retinoids in leukemia and cellular processes
- Breast Cancer Treatment Studies
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Wnt/β-catenin signaling in development and cancer
University of Chieti-Pescara
2015-2025
Sapienza University of Rome
2014-2022
Carrier (United States)
2020
University of Foggia
2020
Università Cattolica del Sacro Cuore
1991-2015
Foundation University Islamabad
2008-2014
University Foundation
2006-2011
University of Naples Federico II
2010
University of Ferrara
2006
University of Milan
2006
Flavonoids are a class of polyphenolic compounds widely distributed in the plant kingdom, which display variety biological activities, including chemoprevention and tumor growth inhibition. Our aim was to investigate effects several polyphenols on metastatic potential B16-BL6 melanoma cells vivo. Intraperitoneal administration quercetin, apigenin, (–)-epigallocathechin-3-gallate (EGCG), resveratrol, anti-estrogen tamoxifen, at time i.m. injection into syngeneic mice, resulted significant,...
Trop-2 is a calcium signal transducer that drives tumor growth. Anti-Trop-2 antibodies with selective reactivity versus maturation stages allowed to identify two different pools of Trop-2, one localized in the cell membrane and cytoplasm. Of note, membrane-localized/functional was found be differentially associated determinants aggressiveness distinct breast cancer subgroups. These findings candidated states having an impact on progression. We tested this model cancer. A large, consecutive...
The overall effect of brain zinc (Zn2+) in the progression and development Alzheimer's disease (AD) is still not completely understood. Although an excess Zn2+ can exacerbate pathological features AD, a deficit intake has also been shown to increase volume amyloid plaques AD transgenic mice. In this study, we investigated dietary supplementation (30 p.p.m.) mouse model 3xTg-AD, that expresses both β (Aβ)- tau-dependent pathology. We found greatly delays hippocampal-dependent memory deficits...
Background The pathogenic road map leading to Alzheimer's disease (AD) is still not completely understood; however, a large body of studies in the last few years supports idea that beside classic hallmarks disease, namely accumulation amyloid-β (Aβ) and neurofibrillary tangles, other factors significantly contribute initiation progression disease. Among them, mitochondria failure, an unbalanced neuronal redox state, dyshomeostasis endogenous metals like copper, iron, zinc have all been...
Abstract We studied the effect of quercetin (Q) on proliferation HT‐29, WiDr, COLO 201, and LS‐174T human colon cancer cell lines. Q, between 10 nM μM, exerted a dose‐dependent, reversible inhibition proliferation. Cell‐cycle analysis revealed that growth‐inhibitory Q was due to blocking action in G 0 /G 1 phase. Using whole‐cell assay with 17β‐[ 3 H]‐estradiol as tracer, we demonstrated all these lines contain type‐II estrogen‐binding sites (type‐II EBS). By using other chemically related...
Immunocytochemical studies have revealed that 10 μM quercetin reduced the steady state levels of p21-ras proteins in both colon cancer cell lines and primary colorectal tumors. These findings were confirmed by Western blot flow cytometric analysis showing inhibition expression was time- concentration-dependent. Twenty-four-hour treatment with to about 50% control values. Quercetin similarly effective inhibiting K-, H-, N-ras proteins. Moreover, effect on ras oncogene not dependent cycle...
Abstract Cell motility and invasion play an essential role in the development of metastasis. Evidence suggests that enzyme phospholipase Cγ1 (PLCγ1) may be involved tumor progression possibly In this study, we show down-regulation PLCγ1 expression severely impairs activation small GTP-binding protein Rac cell breast cancer lines U87 vitro. Experimental metastasis assays nude mice inducible knockdown strongly inhibits MDA-MB-231–derived lung reverts formation. addition, analysis 60 patients'...
Abstract The ErbB tyrosine kinase receptor family has been shown to have an important role in tumorigenesis, and the expression of its members is frequently deregulated many types solid tumors. Various drugs targeting these receptors approved for cancer treatment. Particularly, breast cancer, anti-Her2/EGFR molecules represent standard therapy Her2-positive malignancies. However, a number cases, tumor relapses or progresses thus suggesting that not all cells targeted. One possibility subset...
Congenital tufting enteropathy (CTE) is a life-threatening hereditary disease that characterized by enteric mucosa degeneration and early onset, severe diarrhea. Loss-of-function mutations of the human EPCAM gene (TROP1, TACSTD1) have been indicated as cause CTE. However, loss mTrop1/Epcam in mice appeared to lead death utero, due placental malformation. This indications residual Trop-1/EpCAM expression cases CTE cast doubt on role this disease. The aim study was determine TROP1/EPCAM...
Recent studies have shown that type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction or dementia. Insulin resistance often associated with T2DM and can induce defective insulin signaling in the central nervous system as well increase of impairment elderly. Glucagone like peptide-1 (GLP-1) an incretin hormone and, GLP-1 analogs, stimulates secretion has been employed treatment T2DM. analogs also enhance synaptic plasticity counteract deficits mouse models neuronal and/or...
Frizzled receptors mediate Wnt ligand signalling, which is crucially involved in regulating tissue development and differentiation, often deregulated cancer. In this study, we found that the gene encoding receptor frizzled 6 (FZD6) frequently amplified breast cancer, with an increased incidence triple-negative cancer (TNBC) subtype. Ablation of FZD6 expression mammary cell lines: (1) inhibited motility invasion; (2) induced a more symmetrical shape organoid three-dimensional cultures; (3)...
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S ummary . The presence of oestrogen receptors (ER) and type II binding sites (type IIEBS) have been investigated by a whole cell assay in seven cases acute lymphoid leukaemia (ALL) 16 myeloid (AML). ER were detected 6/7 ALL patients with values ranging between 133 2268 sites/cell 12/16 AML 274 4197 sites/cell. apparent dissociation constant ( K D ) for was 0.6±0.3 nM (mean + SD 20 cases). All blasts from expressed EBS at variable levels 3109 239 450 mean value these 18.3±5.6 (mean±SD 23...
Abstract A chimeric CYCLIN D1-TROP2 mRNA was isolated from human ovarian and mammary cancer cells. The shown to be a potent oncogene as it transforms naïve, primary cells in vitro induces aggressive tumor growth vivo cooperation with activated RAS. Silencing of the inhibits breast expressed by large fraction gastrointestinal, ovarian, endometrial tumors analyzed. It is most frequently detected intestinal cell aneuploid cancers coexpressed RAS oncogenes, consistent cooperative transforming...