A5044990811- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rheumatoid Arthritis Research and Therapies
- Connective Tissue Growth Factor Research
- Mast cells and histamine
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Lymphatic System and Diseases
- Dermatological and Skeletal Disorders
- Skin Diseases and Diabetes
- Systemic Lupus Erythematosus Research
- Autoimmune Bullous Skin Diseases
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Diagnosis and Treatment of Venous Diseases
- Autoimmune and Inflammatory Disorders Research
- Pulmonary Hypertension Research and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Spondyloarthritis Studies and Treatments
- Ultrasound and Hyperthermia Applications
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Urticaria and Related Conditions
University of Florence
2016-2025
Center for Rheumatology
2006-2024
Azienda Ospedaliero-Universitaria Careggi
2014-2024
Monash Medical Centre
2023
Monash University
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2023
Vita-Salute San Raffaele University
2023
National Research Council
2012-2022
Istituto di Fisiologia Clinica
2012-2022
Objective The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity early SSc and limited cutaneous SSc. present work, by a joint committee the ACR European League Against Rheumatism (EULAR), was undertaken purpose developing new Methods Using consensus methods, 23 candidate items were arranged in multicriteria additive point system with threshold to classify cases as reduced clustering simplifying weights. tested 1) determining...
<h3>Objective</h3> The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity early SSc and limited cutaneous SSc. present work, by a joint committee the ACR European League Against Rheumatism (EULAR), was undertaken purpose developing new <h3>Methods</h3> Using consensus methods, 23 candidate items were arranged in multicriteria additive point system with threshold to classify cases as reduced clustering simplifying weights. tested...
To identify overall disease course, progression patterns and risk factors predictive for progressive interstitial lung (ILD) in patients with systemic sclerosis-associated ILD (SSc-ILD), using data from the European Scleroderma Trials And Research (EUSTAR) database over long-term follow-up.
Objective Systemic sclerosis (SSc) features multiorgan fibrosis orchestrated predominantly by activated myofibroblasts. Endothelial-to-mesenchymal transition (EndoMT) is a transdifferentiation which endothelial cells (ECs) lose their specific morphology/markers and acquire myofibroblast-like features. Here, we determined the possible contribution of EndoMT to pathogenesis dermal in SSc two mouse models. Methods Skin sections were immunostained for CD31 or vascular (VE)-cadherin combination...
To examine whether the lack of sufficient neoangiogenesis in systemic sclerosis (SSc) is caused by a decrease angiogenic factors and/or an increase angiostatic factors, potent proangiogenic molecules vascular endothelial growth factor (VEGF) and basic fibroblast factor, endostatin were determined patients with SSc healthy controls. Forty-three established nine pre-SSc included study. Serum levels VEGF, measured ELISA. Age-matched sex-matched volunteers used as Highly significant differences...
<h3>Objectives</h3> The EULAR (European League Against Rheumatism) Scleroderma Trials and Research Group (EUSTAR) has identified preliminary criteria for very early diagnosis of systemic sclerosis (SSc). Our aim was to assess the prevalence each proposed diagnostic item in a large observational patient cohort with Raynaud9s phenomenon (RP). <h3>Methods</h3> Baseline data 469 RP patients enrolled into Very Early Diagnosis Systemic Sclerosis (VEDOSS) are presented. <h3>Results</h3> 68% all...
To evaluate in SSc, the frequency of digital lesions and morphology, characteristics, natural course time to healing 1614 ulcers (DUs).One hundred SSc patients were followed up for 4 years. In first step, observed classified at presentation [digital pitting scar (DPS); DU; calcinosis; gangrene]. second DUs divided into subsets according their origin main features. third was recorded each DU influence characteristics on also evaluated.In observed: DPS, 712 (44.1%) lesions; DU, 785 (48.6%);...
<h3>Background</h3> A high percentage of patients with systemic sclerosis (SSc) develop interstitial lung disease (ILD) during the course disease. Promising data have recently shown that ultrasound (LUS) is able to detect ILD by evaluation B-lines (previously called comets), sonographic marker pulmonary syndrome. <h3>Objective</h3> To evaluate whether LUS reliable in screening SSc. <h3>Methods</h3> Fifty-eight consecutive SSc (54 women, mean age 51±14 years) who underwent a resolution CT...
Systemic sclerosis (SSc) is characterized by widespread microangiopathy, fibrosis, and autoimmunity. Despite the lack of angiogenesis, expression vascular endothelial growth factor A (VEGF) was shown to be upregulated in SSc skin circulation; however, previous studies did not distinguish between proangiogenic VEGF(165) antiangiogenic VEGF(165)b isoforms, which are generated alternative splicing terminal exon VEGF pre-RNA.We investigated whether isoform could altered circulation patients with...
Abstract Objective Systemic sclerosis (SSc) is a disorder characterized by vascular damage and fibrosis of the skin internal organs. Despite marked tissue hypoxia, there no evidence compensatory angiogenesis. The ability mesenchymal stem cells (MSCs) to differentiate into endothelial was recently demonstrated. aim this study determine whether impaired differentiation MSCs in SSc might contribute disease pathogenesis decreasing repair. Methods obtained from 7 patients 15 healthy controls were...
Abstract Telocytes, a peculiar type of stromal cells, have been recently identified in variety tissues and organs, including human skin. Systemic sclerosis ( SS c, scleroderma) is complex connective tissue disease characterized by fibrosis the skin internal organs. We presently investigated telocyte distribution features c patients compared with normal By an integrated immunohistochemical transmission electron microscopy approach, we confirmed that telocytes were present dermis, where they...
Abstract Introduction Covid-19 infection poses a serious challenge for immune-compromised patients with inflammatory autoimmune systemic diseases. We investigated the clinical-epidemiological findings of 1641 disease Italian during pandemic. Method This observational multicenter study included unselected diseases from three geographical areas different prevalence [high in north (Emilia Romagna), medium central (Tuscany), and low south (Calabria)] by means telephone 6-week survey. was...
Systemic sclerosis (SSc) is a complex connective tissue disease characterized by fibrosis of the skin and various internal organs. In SSc, telocytes, peculiar type stromal (interstitial) cells, display severe ultrastructural damages are progressively lost from clinically affected skin. The aim present work was to investigate presence distribution telocytes in organs SSc patients. Archival paraffin-embedded samples gastric wall, myocardium lung patients controls were collected. Tissue...
Abstract Objective The aim of this study was to identify the main CT features that may help in distinguishing a progression interstitial lung disease (ILD) secondary SSc from COVID-19 pneumonia. Methods This multicentric included 22 international readers grouped into radiologist group (RADs) and non-radiologist (nRADs). A total 99 patients, 52 with 47 SSc-ILD, were study. Results Fibrosis inside focal ground-glass opacities (GGOs) upper lobes; fibrosis lower lobe GGOs; reticulations lobes...