A5081980796- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Medical Imaging and Pathology Studies
- Long-Term Effects of COVID-19
- Dermatologic Treatments and Research
- Vasculitis and related conditions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Salivary Gland Disorders and Functions
- COVID-19 and Mental Health
- Scoliosis diagnosis and treatment
- Skin Diseases and Diabetes
- Extracellular vesicles in disease
- Sinusitis and nasal conditions
- Balance, Gait, and Falls Prevention
- Antifungal resistance and susceptibility
- Cerebral Venous Sinus Thrombosis
- Mast cells and histamine
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diabetes and associated disorders
- Pregnancy and preeclampsia studies
- Eosinophilic Disorders and Syndromes
Wroclaw Medical University
2013-2025
Medical University of Silesia
2012
Functional Mobility Assessment (FMA) is a challenging task. One example of an FMA instrumented Timed Up and Go test (iTUG). Sensor-based interventions are more effective than traditional that use clinical tests to assess patient’s FMA. Background/Objectives: The aim this study investigate the variability selected parameters Time using inertial measurements in healthy younger adults. Methods: A total 73 subjects participated study, including 37 women 36 men. mean age was 31 years (SD 5.5...
Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by tissue fibrosis and immune abnormalities. Recent evidence suggests that activated circulating monocytes from patients with SSc play an important role in early stages of pathogenesis due to enhanced expression inhibitor metalloproteinases 1 (TIMP-1), IL-8 reactive oxygen species (ROS) induction. However, the exact factors contribute inflammation subsequently progression are still unknown.The pattern IL-8, TIMP-1, AP-1...
Introduction: The total number of confirmed cases COVID-19 caused by the SARS-CoV-2 virus infection is over 621 million in world. In approximately 63% cases, patient still experiences persistent symptoms 30 days after onset or hospitalisation, and 45.9% patients have experienced will experience for at least three months. Despite prevalence chronic pathological changes that may affect gait functional mobility people with a history COVID-19, there are few publications investigating impact...
Objective. To assess patients with SSc who present without circulating ANAs or RP. Methods. Five thousand three hundred and ninety fulfilled the ACR criteria for were enrolled in EULAR Scleroderma Trials Research (EUSTAR) database screened absence of both RP ANA. differentiate from its mimics, additional information was gathered using a standardized questionnaire. Results. seventy-eight (99.8%) 5390 EUSTAR had either detectable ANA history Twelve (0.2%) lacked Details medical could be...
Vaccination is the best way to limit extent of COVID pandemic. Knowledge duration immune response will allow planning a vaccination protocol. This study aims validate complete (humoral and cellular) responses over time in large population groups following full healthcare professionals real-life conditions assess relationship between antibody levels T-cell activity relation characteristics group. The samples for were obtained from volunteers (staff two hospitals) on three occasions: before...
There is accumulating evidence on the perinatal aspects of COVID-19, but available data are still insufficient. The reports COVID-19 have been published a small group patients. Vertical transmission has noted. SARS-CoV-2 genome can be detected in umbilical cord blood and at-term placenta, infants demonstrate elevated SARS-CoV-2-specific IgG IgM antibody levels. In this work, analysis clinical characteristics RT-PCR SARS-CoV-2-positive pregnant women their infants, along with placental...
Background: The COVID-GRAM is a clinical risk rating score for predicting the prognosis of hospitalized COVID-19 infected patients. Aim: Our study aimed to evaluate use in patients with based on data from COronavirus LOwer Silesia (COLOS) registry. Material and methods: group (834 Caucasian patients) was retrospectively divided into three arms according achieved calculated at time hospital admission (between February 2020 July 2021): low, medium, high risk. Omnibus chi-square test, Fisher...
Background. The therapeutic effects of cyclophosphamide (CP) in the treatment systemic rheumatic diseases are related to its immune suppressive activity. However effective, application CP is restricted due multiple adverse effects.Objectives. This retrospective study was conducted determine frequency attributed toxicity.Material and Methods. involved 65 patients (17 male; 48 female) receiving intravenous between October 2007 December 2010. mean age at onset 51.2 years (range 19–77 years)....
The broad spectrum of interactions between autoimmune diseases and the SARS-CoV-2 vaccination is not fully understood. This study aims to evaluate prevalence anti-nuclear antibodies (ANA), anti-ENA, anticardiolipin (ACL), anti-beta-2 glycoprotein I (anti-β2GPI) before after mRNA in a real-life setting healthcare professionals. identification risk factors associated with vaccine immunogenicity was evaluated. group consisted employees two hospitals (354 individuals). Samples for antibody...
Background.Previous research suggests that systemic involvement in primary Sjögren's syndrome (pSS) is a marker of disease prognosis.Objectives.To evaluate pSS activity and the clinical phenotype patients depending on age at diagnosis with long-term follow-up. Materials methods.The study group consisted diagnosed based 2016 classification criteria.Results.The 46 early-onset (≤35 years age) 32 late-onset (≥65 age).The was identified from total 228 pSS.There were no differences regarding...
Medical workers are a group that is particularly vulnerable to infection during the coronavirus disease 2019 (COVID-19) pandemic.The study aimed assess risk of COVID-19 and its course in medical staff COVID-only non-COVID hospital.The observational included 732 participants who were workers. The was conducted between June 2020 December 2020, before widespread immunization introduced.Of employees hospitals, 377 had history COVID-19. twice as high hospital compared (odds ratio (OR) = 2.0; p <...
The total number of confirmed cases COVID-19 caused by SARS-CoV-2 virus infection is over 621 million. Post-COVID-19 syndrome, also known as long COVID or long-haul COVID, refers to a persistent condition where individuals experience symptoms and health issues after the acute phase COVID-19. aim this study was assess strength fatigue skeletal muscles in people recovered from A 94 took part cross-sectional study, with 45 participants (referred Post-COVID Cohort, PCC) 49 healthy age-matched...
Background: The EULAR Sjögren’s syndrome (SS) disease activity index (ESSDAI) pulmonary domain is used to assess the of respiratory system involvement in (SjD). most unfavorable form SjD, after lymphomas, interstitial lung (ILD). Objectives: aim study was SjD patients and occurrence ILD high-resolution computed tomography (HRCT), depending on immunological markers, influence cigarette smoking, age patients. Design: Single-center, registry, cohort study. Methods: Among all patients, a group...
Background: Research confirms that Candida spp. incubated with methotrexate develop multi-drug resistance to azoles, but it is not clear whether this phenomenon occurs in vivo patients treated cytostatics. The aim of the study was assess systemic therapy induces azoles among endogenous strains rheumatological diseases. Methods: test group consisted 52 on therapy, who have never been exposed fluconazole. control composed 49 individuals either or Oral swab and clinical information were...
<h3>Background and objectives</h3> Systemic sclerosis (SSc) is a chronic multisystem autoimmune disease characterised by skin internal organs fibrosis immune abnormalities. Recent evidence suggests that activated circulating monocytes from SSc patients play role in pathogenesis due to enhanced expression of tissue inhibitor metalloproteinases 1 (TIMP-1), IL-8 reactive oxygen species (ROS) induction, which contribute progression inflammation. The exact factors driving TIMP-1, ROS...
<h3>Background and objectives</h3> To investigate whether epigenetic changes induced by 3’deazaneplanocin - DZNep TLR signalling pathway can modulate monocytes to produce tissue-inhibitor of metalloproteinase-1 (TIMP-1) via Fra2 (Fos-related antigen 2) activity, a novel downstream mediator promoting fibrogenesis. <h3>Methods</h3> AP-1 TIMP-1 expression following TLR8 treatment was measured qRT-PCR in from Systemic sclerosis (SSc) patients (n = 13) healthy controls (HC) 13). promoter activity...
Background Systemic sclerosis (SSc) is an autoimmune disease of unknown etiology which affects the whole body. Extensive fibrosis skin and internal organs (including lungs – interstitial lung (ILD)) are typical for SSc. However level NO in exhaled air has been limited diagnostic value. Previous studies suggest that it seems to be a good predictor involvement pulmonary tissue [1,2,3]. Some authors can even marker early disease. Objectives To measure group patients with SSc compare...