Kamal Solanki
A5033925533- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Dermatologic Treatments and Research
- Orthopedic Infections and Treatments
- Hematological disorders and diagnostics
- Medical Imaging and Pathology Studies
- Autoimmune Bullous Skin Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Skin Diseases and Diabetes
- Mast cells and histamine
- Radiopharmaceutical Chemistry and Applications
- Rheumatoid Arthritis Research and Therapies
- MRI in cancer diagnosis
- Bone health and treatments
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Osteomyelitis and Bone Disorders Research
- Infectious Diseases and Tuberculosis
- Pharmaceutical studies and practices
- Diagnosis and Treatment of Venous Diseases
- Musculoskeletal Disorders and Rehabilitation
- Medical Imaging Techniques and Applications
- Bacterial Infections and Vaccines
- Gastrointestinal disorders and treatments
- Streptococcal Infections and Treatments
Waikato Hospital
2010-2024
University of Auckland
2015-2024
Apollo Hospitals
2024
Gandhi Medical College
2024
Scleroderma Foundation
2022
University of Michigan
2022
Waikato District Health Board
2017-2021
University of Florence
2021
Pennine Acute Hospitals NHS Trust
2016
Cambridge University Hospitals NHS Foundation Trust
2014
Objectives To determine the causes of death and risk factors in systemic sclerosis (SSc). Methods Between 2000 2011, we examined certificates all French patients with SSc to death. Then developed a score associated all-cause mortality from international European Scleroderma Trials Research (EUSTAR) database. Candidate prognostic were tested by Cox proportional hazards regression model single variable analysis, followed multiple stratified centres. The bootstrapping technique was used for...
To characterize patients with positive anti-topoisomerase I (ATA) in lcSSc.SSc enrolled the EUSTAR cohort a disease duration of ≤3 years at database entry were considered. We assessed risk major organ involvement following groups: ATA-lcSSc vs ACA-lcSSc and ANA without specificity (ANA)-lcSSc, ATA-dcSSc. Cox regression models time-dependent covariates performed outcomes: new-onset interstitial lung (ILD), ILD progression [forced vital capacity (FVC) decline ≥10% ≥5% values diagnosis),...
To evaluate the use of hydroxychloroquine (HCQ) and its impact on Health Assessment Questionnaire disability index(HAQ-DI) Cochin Hand Function Status(CHFS) in a large Systemic Sclerosis (SSc) cohort. SSc patients from European Scleroderma Trials Research (EUSTAR) database treated with HCQ for at least 6 months were evaluated compared to matched group not using HCQ. Demographic clinical data, concomitant drugs, HAQ-DI CHFS (at 2 evaluations) recorded outcome variables interest. Statistical...
Abstract Objective Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate impact sex on SSc-ILD. Methods EUSTAR SSc patients with radiologically confirmed ILD available percentage predicted forced vital capacity (%pFVC) were included. Demographics features recorded. A change %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (≤4%), mild (5–9%) large progression (≥10%). In those 2-year...
In patients with SSc, peripheral vasculopathy can promote critical ischaemia and gangrene. The aim of this study was to investigate the prevalence, incidence risk factors for gangrene in EUSTAR cohort.We included from database fulfilling ACR 1980 or ACR/EULAR 2013 classification criteria at least one visit recording data on Centres were asked supplementary traditional cardiovascular factors. We analysed cross-sectional relationship between its potential by univariable multivariable logistic...
Aim Cutaneous involvement is an early manifestation of systemic sclerosis (SSc). Localized areas ‘salt and pepper skin’ (S&P) may develop. We hypothesize that S&P skin occurs frequently in diffuse cutaneous (dc) SSc which can be used its diagnosis correlate with joint contractures. Methods Sixty-five patients were recruited for this study. The demographic profiles ascertained from hospital records. These fulfilled the 2013 American College Rheumatology/European League Against Rheumatism...
SSc is a chronic autoimmune disease characterized by inflammation of the skin and multiple internal organs. Articular involvement one main features SSc, typical hallmarks SpA have been found in patients. The aim present study was to estimate prevalence entheseal synovio-entheseal complex (SEC) alterations cohort patients.One hundred patients 25 healthy subjects were included this cross-sectional study. enthesis sites lateral epicondylar common extensor tendons (CET) Glasgow Ultrasound...
Patients with diffuse cutaneous systemic sclerosis (dcSSc) frequently show spontaneous improvement of skin fibrosis. Our aim was to examine whether an in fibrosis predicts lower likelihood visceral organ progression and better survival.
Abstract Objective To characterize the causes of mortality and standardised ratio in a cohort patients with systemic sclerosis ( SS c). Methods A 132 enrolled at Waikato Systemic Sclerosis Clinic was prospectively followed from 2005 to 2016. Patient demographics, diagnoses laboratory reports were used assess risk generate ratios SMR ). Survival analyzed using Kaplan‐Meier methods. Results Of patients, 20 (15%) deceased by end study period. The median age diagnosis death 52 years (range...
Abstract Background Biofeedback therapy ( BFT ) is an established treatment for fecal incontinence FI ), with access often being restricted to tertiary centers due resources and the perceived requirement high‐intensity regimes. However, optimal regime remains unknown. We evaluated outcomes from our low‐intensity integrated program in a secondary care center. Methods Outcomes of service were retrospectively. Response was defined by ≥50% improvement frequency baseline or complete continence....
Immunoglobulin (Ig)G4-related disease (IgG4-RD) with retroperitoneal fibrosis (RPF) is a rare, fibroinflammatory involving the soft tissues of retroperitoneum. A 73-year-old man IgG4-related RPF affecting abdominal aorta and iliac arteries was treated steroids mycophenolate mofetil. The prevalence remains unknown because it often misdiagnosed can mimic many malignant, infectious, inflammatory conditions. Autoimmune pancreatitis common presenting condition IgG4-RD. Because As IgG4-RD...
Abstract Objectives The early trajectory of skin fibrosis provides insights into the disease course systemic sclerosis (SSc) including mortality; however, little is known about late fibrosis. aims our study were to ascertain prevalence and characteristics in SSc. Methods We developed tested three conceptual scenarios (>5 years after first non-RP feature) new worsening disease, failure improve within 5-year window. defined as change modified Rodnan score (mRSS) ≥5 units or ≥25%. Using...
Systemic sclerosis (SSc) can present as an overlap syndrome with rheumatoid arthritis (SSc-RA overlap).To evaluate the frequency of factor (RF) and anticyclic citrullinated peptide antibodies (anti-CCP) in our SSc cohort their association clinical features.Data were gathered prospectively from Waikato Hospital Sclerosis Clinics. Patients SOS (systemic syndrome) underwent baseline auto-antibody profiling including RF anti-CCP along annual review.Our comprised 132 patients (two had incomplete...