A5023199627- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Dermatologic Treatments and Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Diagnosis and Treatment of Venous Diseases
- Systemic Lupus Erythematosus Research
- Skin Diseases and Diabetes
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
- RNA regulation and disease
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Climate Change and Health Impacts
- Sex and Gender in Healthcare
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Health and Disease Prevention
- Abdominal vascular conditions and treatments
- Dermatological and COVID-19 studies
- Long-Term Effects of COVID-19
- Autoimmune Bullous Skin Diseases
- Sympathectomy and Hyperhidrosis Treatments
- Pericarditis and Cardiac Tamponade
- Telemedicine and Telehealth Implementation
Ospedale Sandro Pertini
2014-2024
Associazione Italiana Sclerosi Multipla
2020-2024
ASL Roma
2024
Sapienza University of Rome
2002-2004
To investigate the existence of a relationship among flow-mediated dilation (FMD), nitric oxide (NO), and oxidative stress in patients with peripheral arterial disease (PAD), to assess if administration an antioxidant was able improve dilatation.We performed cross-sectional study comparing FMD, 8-Hydroxy-2-deoxy-2-deoxyguanosine (8-OHdG), marker stress, nitrite/nitrate (NOx) serum levels population 25 PAD 40 controls. In second part study, 21 were randomly allocated treatment sequence 7 days...
To investigate whether patients affected by 1 of the 3 subsets early systemic sclerosis (SSc; scleroderma), i.e., subset I, Raynaud's phenomenon with SSc marker autoantibodies and typical capillaroscopic findings; II, autoantibody positive only; III, capillaroscopy only not satisfying 2013 American College Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for at admission, differ from each other in time to satisfy criteria.Early subdivided into indicated...
Early systemic sclerosis (SSc) is characterized by Raynaud's phenomenon together with scleroderma marker autoantibodies and/or a pattern at capillaroscopy and no other distinctive feature of SSc. Patients presenting plus capillaroscopic seem to evolve into definite SSc more frequently than patients either feature. Whether early only or positivity differ in any aspect presentation unclear. Seventy-one consecutive were investigated for preclinical cardiopulmonary alterations. Out these, 44 25...
Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it well established that autosomal recessive mutations in the WRN gene responsible for syndrome, molecular alterations lead to disease phenotype remain still unidentified. To address whether epigenetic changes can be associated with phenotype, we analysed genome-wide DNA methylation profile using Infinium MethylationEPIC BeadChip whole blood from three patients affected compared age- and...
According to the World Health Organization, cardiovascular disease (CVD) is leading cause of death among women worldwide, yet its magnitude often underestimated. Biological and gender differences affect health, diagnosis, healthcare in numerous ways. The lack sex awareness health research an ongoing issue that affects not only but also treatment outcomes. importance recognizing impacts both on knowing between two beginning gain ground. There more appreciation roles biological (sex)...
For many years observational studies and clinical trials on systemic sclerosis (SSc) have been carried out only patients who met the 1980 American College of Rheumatology-ACR preliminary classification criteria. However, this lead to exclusion from all those subset patients, particularly with a limited cutaneous SSc-sine scleroderma subset, because, despite diagnosis SSc based Raynaud's phenomenon (RP) associated digital pitting scars/ulcers, or by sclerodactyly telangiectasia and/or typical...
Buerger's disease (BD) remains a debilitating condition and early diagnosis is paramount for its effective management. Despite many published diagnostic criteria BD, selective have been utilized in different vascular centers to manage patients with BD worldwide. A recent international Delphi Consensus Study on the of showed that none these universally accepted as gold standard. Apart from presence smoking, distinct differences between them, rendering direct comparison patient outcomes...
Review Articles| August 14 2003 Red and white wine differently affect collagen-induced platelet aggregation Subject Area: Cardiovascular System , Hematology Pathology Cell Biology Pasquale Pignatelli; Pignatelli Search for other works by this author on: This Site PubMed Google Scholar Luisa Lenti; Lenti Fabio M. Pulcinelli; Pulcinelli Roberto Catasca; Catasca 2ASL Viterbo Distretto VT1 Montefiascone. Gloria Saccani; Saccani 3Dipartimento di Igene Pubblica, Sezione Igiene, Università degli...
Impaired thyroid hormone availability during early pregnancy is associated with recurrent miscarriage (RM) and adverse outcomes. The main cause of dysfunction thyroid-related autoimmunity (TAI), characterized by a significantly higher serum level thyroid-stimulating (TSH) compared to that women without autoimmunity. TAI increased risk miscarriage, the incidence in experiencing RM normal fertile women. In present study, we have performed retrospective analysis comparing ability conceive,...
We present a case of severe interstitial pneumonitis, mild polyarthritis and polymyositis, Raynaud's syndrome with the presence anti-Jo-1 antibodies, which had been diagnosed as anti-synthetase syndrome. The presence, however, anti-Ro/SSA antibodies led us to understand that we were dealing here more form lung disease. patient was treated for acute respiratory failure but he showed resistance glucocorticoids cyclosporine. Thus, infusions anti-CD20 therapy (rituximab): his clinical conditions...
The term "microcirculation" refers to the terminal vascular network of body, which includes arterioles, capillaries, venules as well initial lymphatic vessels. Additionally, it insinuates their unique function in thermoregulation, fluid balance, maintenance cellular exchange, and metabolism. Disturbances microvascular were identified precede macrovascular involvement presence cardiovascular risk factors is hallmark disease stages like critical limb or acral ischemia. Nevertheless, despite...
This study aimed to investigate the presence of psychopathological symptoms and relations these dimensions with quality life sexual function in a group women affected by systemic scleroderma.
According to the World Health Organization, cardiovascular disease (CVD) is leading cause of death among women worldwide, yet its magnitude often underestimated. Biological and gender differences affect health, diagnosis, healthcare in numerous ways. The lack sex awareness health research an ongoing issue affects not only research, but also treatment outcomes. importance recognising impact both on knowing between two beginning gain ground. There more appreciation role that biological (sex)...
Background: Telemedicine is increasingly used in several fields of healthcare, including vascular medicine. This study aimed to investigate the views experts and propose clinical practice recommendations on possible applications telemedicine Methods: A guidance group proposed a set 67 based synthesis current evidence expert opinion. The Vascular Medicine Working Group included 32 from Europe evaluating appropriateness each recommendation published RAND/UCLA methodology two rounds. Results:...