A5015535677- Autism Spectrum Disorder Research
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Obsessive-Compulsive Spectrum Disorders
- Metabolism and Genetic Disorders
- Hemophilia Treatment and Research
- Mental Health Research Topics
- Tryptophan and brain disorders
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Child Nutrition and Feeding Issues
- Child Development and Digital Technology
- Neurotransmitter Receptor Influence on Behavior
- HIV Research and Treatment
- Infant Development and Preterm Care
- Eating Disorders and Behaviors
- Memory and Neural Mechanisms
- Primate Behavior and Ecology
- Cardiovascular Health and Disease Prevention
- Platelet Disorders and Treatments
- Family and Disability Support Research
- Nutritional Studies and Diet
- HIV/AIDS drug development and treatment
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
Istituto Superiore di Sanità
2016-2025
Institute of Behavioral Sciences
2023
National Institute of Health
2007-2023
National Research Council
2020
Health City Institute
2004-2012
National Institutes of Health
2012
Sapienza University of Rome
1992-2003
University of Campania "Luigi Vanvitelli"
1998
University of Oslo
1997
University of Florence
1993-1997
Novelty seeking as well amphetamine sensitization were studied in adult (postnatal day "PND" > 60) and periadolescent (PND 3343) mice treated with saline or (2 10 mg/kg once per day) for 3 days a familiar environment. After 48-hr wash-out period, challenged either mg/kg) the same When given choice, animals showed preference novel environment, an effect more marked periadolescents. Acute strongly increased novelty adults, whereas it had opposite Adult chronic 2 group conditioned drug-paired...
Italy is one of the high-income countries hit hardest by Covid-19. During first months pandemic, Italian healthcare workers were praised media and public for their efforts to face emergency, although with limited knowledge resources. However, soon had new challenges at a time when national health system was working hard recover. This study focuses on this difficult period assess impact COVID-19 pandemic mental workers.Healthcare from all regions [n = 5,502] completed an online questionnaire...
Abstract The present study evaluated the effects of a single intrahippocampal administration brain‐derived neurotrophic factor (BDNF) on memory retention in water maze. Adult rats were trained maze (acquisition phase, day 1). Immediately after last training trial subjects injected right hippocampus with either BDNF (24 μg) or phosphate‐buffered saline (1 μl). On 2, all tested for probe and subsequently reversal learning. While no differences emerged trial, BDNF‐treated showed shorter latency...
1. In Italy small water bodies, especially temporary ones, have been little studied. As a consequence, their conservation value as biodiversity resource is often overlooked despite Mediterranean waters being listed priority habitat in the Habitats Directive (92/43/EEC). 2. A monitoring programme was designed to determine which factors influence pond species richness, and analyse variation macroinvertebrate community structure within among ponds. Three main contrasting mesohabitats...
To assess the role of genetic variation in determining factor VII (FVII) activity and antigen levels we studied a polymorphism located 5′ region gene (5′F7), an intronic mutation (IVS7), 353 Arg-Gln polymorphism. All polymorphisms, which showed strong allelic association, analyzed separately or combination by one-way analysis variance, were associated with significantly different FVII levels. The 5′F7 polymorphic systems, have very similar allele frequencies, contributed to extent total...
Abstract Background One of the cardinal principles homeopathy is "law similarities", according to which patients can be treated by administering substances which, when tested in healthy subjects, cause symptoms that are similar those presented themselves. Over last few years, there has been an increase number pre-clinical ( vitro and animal) studies aimed at evaluating pharmacological activity or efficacy some homeopathic remedies under potentially reproducible conditions. However, addition...
To investigate the existence of a relationship among flow-mediated dilation (FMD), nitric oxide (NO), and oxidative stress in patients with peripheral arterial disease (PAD), to assess if administration an antioxidant was able improve dilatation.We performed cross-sectional study comparing FMD, 8-Hydroxy-2-deoxy-2-deoxyguanosine (8-OHdG), marker stress, nitrite/nitrate (NOx) serum levels population 25 PAD 40 controls. In second part study, 21 were randomly allocated treatment sequence 7 days...
Organophosphorus insecticides, as Chlorpyrifos (CPF), are widely used in agriculture and against household pests; these compounds receive an increasing consideration potential endocrine disrupters. The aim of the present study was to examine short- long-term effects CPF on thyroid adrenal glands CD1 mice following exposure at dose levels not inducing brain acetyl cholinesterase (AchE) inhibition, during gestational and/or postnatal vulnerable phases. Pregnant dams were treated with 0, 3, 6...
Emotional disturbances constitute a major health issue affecting considerable portion of the population in western countries. In this context, animal models offer relevant tool to address underlying biological determinants and screen novel therapeutic strategies. While rodents have traditionally constituted species choice, zebrafish are now becoming viable alternative. As gain momentum biomedical sciences, efforts being devoted developing high-throughput behavioral tests. Here, we present...
The existing literature on the treatment of pediatric chronic tic disorder (CTD) and Tourette syndrome (TS) indicates that both behavioral therapy (BT) pharmacotherapy (PT) are effective for reducing symptoms.To evaluate efficacy BT compared to psychoeducation (PE) or PT tics co-occurring symptoms improving quality life (QoL) in a sample youths with CTD TS.A 10 weeks, 2 sites (Catania, Rome) randomized controlled trial. Participants were receive one following treatments: BT, PE, PT.110...
Abstract Selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressant drugs, have a variable and incomplete efficacy. In order to better understand SSRI action, we explored hypothesis that SSRIs do not affect mood per se but amplify influence of living conditions on mood. To this aim, exploited Sequenced Treatment Alternatives Relieve Depression (STAR*D) data set, selected subpopulation 591 patients with an overlapping clinical history analyzed treatment...
The studies on the impact of selenium (Se) levels in different pregnancy periods child psychomotor functions are limited. aim this study was to evaluate prenatal Se neurodevelopment. population consisted 410 mother–child pairs from Polish Mother and Child Cohort. were measured each trimester pregnancy, at delivery, cord blood by graphite furnace atomic absorption spectrometry. Psychomotor development assessed children age 1 2 y using Bayley Scales Infant Toddler Development. Plasma decreased...
A standardized neuropsychological test battery was administered to 167 patients with different forms of mild-to-moderate dementia: probable Alzheimer dementia (AD: n = 49), multi-infarct (n 43), idiopathic Parkinson disease 35), depressive pseudodementia 26), and progressive supranuclear palsy 14). Results obtained were used (a) analyze the profiles cognitive impairment shown by groups; (b) assess incidence some patterns that we hypothesized be more characteristic AD, in various hence (c)...