A5058566955- Multiple Sclerosis Research Studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Peripheral Neuropathies and Disorders
- Visual perception and processing mechanisms
- Vestibular and auditory disorders
- Systemic Lupus Erythematosus Research
- Ophthalmology and Eye Disorders
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Glaucoma and retinal disorders
- Myasthenia Gravis and Thymoma
- Autoimmune Neurological Disorders and Treatments
- Neuroscience and Music Perception
- Optical Imaging and Spectroscopy Techniques
- Cerebral Venous Sinus Thrombosis
- LGBTQ Health, Identity, and Policy
- Air Quality and Health Impacts
- Tactile and Sensory Interactions
- Muscle activation and electromyography studies
- Schizophrenia research and treatment
- Systemic Sclerosis and Related Diseases
- Neurological disorders and treatments
- Hearing Loss and Rehabilitation
- Immunotherapy and Immune Responses
University of Florence
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2002-2021
Urology Foundation
1987-2020
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
2004-2019
University of Pavia
1998-2013
Foundation Center
2013
University of Milan
2013
Fondazione Audiologica Varese
2013
Policlinico San Matteo Fondazione
2013
Fondazione FADOI
2001-2011
Acute disseminated encephalomyelitis (ADEM) refers to a monophasic acute multifocal inflammatory CNS disease. However, both relapsing and site-restricted variants, possibly associated with peripheral nervous system (PNS) involvement, are also observed, systematic classification is lacking.To describe cohort of postinfectious ADEM patients, propose based on clinical instrumental features, identify subgroups patients different prognostic factors.Inpatients Neurologic Infectious Disease Clinic...
We studied repeated cerebrospinal fluids of patients with Devic's neuromyelitis optica (NMO) and multiple sclerosis (MS). Variations oligoclonal bands (OBs) had opposite trends in the two groups. In MS, OBs were detected 399 411 (97%) never disappeared. NMO, three 11 (27%) always The hypothesis that NMO MS follow distinct pathogenetic pathways is supported by our findings, which can be useful for differentiation from MS.
Few studies have analysed long-term effects of immunomodulatory disease modifying drugs (DMDs).Assessment the efficacy DMDs on evolution multiple sclerosis, using a Bayesian approach to overcome methodological problems related open-label studies.MS patients from three different Italian sclerosis centres were divided into subgroups according presence treatment in their history before endpoint, which was represented by secondary progression. Patients stratified basis risk score BREMS (Bayesian...
Postinfectious neurologic syndromes (PINSs) of the CNS include heterogeneous disorders, sometimes relapsing. In this study, we aimed to a) describe spectrum PINSs; b) define predictors outcome in and c) assess clinical/paraclinical features that help differentiate PINSs from multiple sclerosis (MS).In prospective cohort adult inpatients with underwent extensive diagnostic assessment therapeutic protocols at inclusion during a minimum 2-year follow-up. We compared them newly diagnosed,...
Several authors have used advanced magnetic resonance imaging (MRI) techniques to investigate whether patients with neuromyelitis optica (NMO) occult damage in normal-appearing brain tissue, similarly multiple sclerosis (MS). To date, the literature contains no data derived from combined use of several MRI same NMO subjects.We set out determine could be detected tissue a small group using multiparametric approach.Eight female affected by (age range 44-58 years) and seven sex- age-matched...
Some environmental factors have been already associated to increased risk of multiple sclerosis (MS), but it is plausible that additional might play a role.To investigate in MS patients the relationship between inflammatory activity, detected by brain magnetic resonance imaging (MRI) with gadolinium (Gd), and air pollution, namely, particulate matters diameter less than 10 μm (PM10).We analyzed from 52 remitting 226 MRIs, 34% (Gd+MRI) 66% without (Gd-MRI) T1-Gd-enhancing lesions. Daily...
Abstract Objective Air pollution has been recently identified as a risk factor for multiple sclerosis. Aim of this study was to investigate the immunological mechanism underlying clinical association between air pollution, namely exposure particulate matter 10 (PM10), and inflammatory activity sclerosis (MS) Methods Daily recording PM10 obtained by monitors depending on residence subjects. Expression molecules involved in activation, adhesion, migration T lymphocytes were tested flow...
Twenty chronic male schizophrenic subjects aged 30-50 years were examined by an auditory event-related potential procedure for the evaluation of P300 component, a CT scan and neuropsychological test battery. The latency was increased its amplitude reduced. measures showed lateral third ventricle enlargement, there global impairment. Poor performances consistently associated with delayed latencies, but not measures. Ventricular enlargement more pronounced among negative family history major...
Chronic cerebrospinal venous insufficiency (CCSVI) has recently been reported to be associated with multiple sclerosis (MS). However, its actual prevalence, possible association specific MS phenotypes, and potential pathophysiological role are debated. We analysed the clinical data of 710 patients attending six centres (five Italian one Canadian). All were submitted Doppler sonography diagnosed as having or not CCSVI according criteria Zamboni et al. Overall, was in 86% patients, but...
Sixty relapsing remitting multiple sclerosis (MS) patients were selected on the basis of their score Fatigue Severity Scale (FSS) and formed two groups: 40 (fatigued MS; MSf) scored above 75th percentile a previously assessed representative MS sample (100 patients), 20 age- sex-matched (nonfatigued patients; MSnf) below 25th percentile. The underwent clinical evaluation (Expanded Disability Status (EDSS)), further assessment fatigue (Fatigue Impact Scale), scales evaluating depression...
<b>Aim:</b> To propose a simple tool for early prediction of unfavourable long term evolution multiple sclerosis (MS). <b>Methods:</b> A Bayesian model allowed us to calculate, within the first year disease and each patient, Risk Estimate MS (BREMS) score that represents risk reaching secondary progression (SP). <b>Results:</b> The median BREMS scores were higher in 158 patients who reached SP 10 years compared with 1087 free (0.69 vs 0.30; p<0.0001). value was related whole cohort...
<h3>Background</h3> Age-standardised death rates from acute myocardial infarction (AMI) and ischaemic heart disease (IHD) have been declining in most developed countries. However, the magnitude of such reductions how they impact on failure are less certain. We sought to assess compare temporal trends mortality failure, AMI non-AMI IHD over a 30-year period England. <h3>Methods</h3> analysed registration data for multiple-cause-coded all deaths people aged 35 years England 1995 2010,...
Few data are available on how often MRI reports provide sufficient information for clinical decision making in patients with multiple sclerosis (MS). The aim of this study is to evaluate if structured reporting MS contain adequate compared nonstructured reporting.Brain and spinal cord suspected or known before after implementation a template were included. Brain assessed presence 11 three key features relevant management MS, respectively. Three neurologists evaluated images assess lesion...
Abstract Purpose We evaluated differences in Autism Spectrum Quotient (AQ) scores between a sample of hormone-naïve transgender and cisgender people the impact gender-affirming hormonal treatment (GAHT) on AQ across time. Furthermore, we assessed alexithymia social anxiety as possible mediators changes scores. Methods A cross-sectional comparison before GAHT prospective study effects over time were performed. Transgender completed several psychometric tests. total 789 persons ( n = 229...
We have developed a databank screening procedure, the In Silico Trans-splicing Retrieval System (ISTReS), to identify heterologous, spliced mRNAs with potential origin from chromosomal translocations, mRNA trans-splicing and multi-locus transcription. A parsing algorithm screen cDNA versus genome Blast outputs was implemented. Key filtering criteria were scores of > or =300, match lengths =95% query sequences, junction two partners at exon-exon borders concordant 'sense/sense' reading...
The records of 142 patients with generalized autoimmune myasthenia gravis who had been treated steroids as the single immunosuppressive agent, collected at regular intervals, were employed for a retrospective evaluation. effectiveness treatment was assessed after 24 months; data from 6th and 12th months also considered. After months, 63.4% whole sample improved (33.8% in clinical or pharmacological remission); 13.4% unchanged worsened 22.3% moved to different treatment. rate positive outcome...