A5045776664- Immune Cell Function and Interaction
- HIV Research and Treatment
- T-cell and B-cell Immunology
- LGBTQ Health, Identity, and Policy
- Signaling Pathways in Disease
- Systemic Lupus Erythematosus Research
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- HIV/AIDS drug development and treatment
- Estrogen and related hormone effects
- Urticaria and Related Conditions
- HIV-related health complications and treatments
- Chronic Lymphocytic Leukemia Research
- Sexuality, Behavior, and Technology
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- interferon and immune responses
- Reproductive System and Pregnancy
Istituto Superiore di Sanità
2015-2025
National Institute of Health
2023-2024
Sapienza University of Rome
1995-2015
Center for Neurosciences
2007
Istituti di Ricovero e Cura a Carattere Scientifico
2003
University of Modena and Reggio Emilia
2002-2003
Istituto Dermopatico dell'Immacolata
2002
We investigated several phenotypic and functional parameters of T cell-mediated immunity in a large series common variable immunodeficiency (CVID) patients. demonstrated that the vast majority CVID patients presented multiple cell abnormalities intimately related among them, severity which was reflected parallel loss CD4+ naive cells. A strong correlation between number cells clinical features observed, supporting subgrouping according to their lymphocytes. reduced thymic output disrupted...
Autophagy, the cytoprotection mechanism that takes place under metabolic impairment, has been implicated in pathogenesis of autoimmunity. Here, we investigated spontaneous and induced autophagic behavior T lymphocytes from patients with systemic lupus erythematosus (SLE) compared healthy donors by measuring autophagy marker microtubule-associated protein 1 light chain 3 (LC3)-II. No significant differences were found between SLE donors, apart CD4+ naive cells which constitutively higher...
// Marina Pierdominici 1 , Angela Maselli 2 Barbara Varano 3 Cristiana Barbati Paola Cesaro 4 Cristiano Spada Angelo Zullo 5 Roberto Lorenzetti Marco Rosati 6 Gabriella Rainaldi Maria Rosaria Limiti Luisa Guidi 7 Lucia Conti 3,* and Sandra Gessani Department of Cell Biology Neurosciences, Istituto Superiore di Sanità, Rome, Italy Therapeutic Research Medicines Evaluation, Hematology, Oncology Molecular Medicine, Digestive Endoscopy Unit, Catholic University, Gastroenterology...
Abstract Objective Estrogens influence many physiologic processes and are also implicated in the development or progression of numerous diseases, including autoimmune disorders. Aberrations lymphocyte homeostasis that lead to production multiple pathogenic autoantibodies, autoantibodies specific estrogen receptor (ER), have been detected peripheral blood patients with systemic lupus erythematosus (SLE). This study was undertaken assess presence both anti‐ERα anti‐ERβ antibodies sera from...
Endothelial dysfunction has been detected in RA patients and seems to be reversed by control of inflammation. Low circulating endothelial progenitor cells (EPCs) have described many conditions associated with increased cardiovascular risk, including RA. The aim this study was investigate the effect inhibition TNF on EPCs patients. Seventeen moderate-severe 12 sex age-matched controls were evaluated. biomarkers tested at baseline after 3 months. identified from peripheral blood mononuclear...
Visceral adipose tissue (VAT) is a main site where metabolic and immunologic processes interplay to regulate, at local systemic level, the inflammatory status immune response. Obesity-associated inflammation dysfunctions are inextricably linked tumor but, in spite of intense efforts, mechanisms underpinning this association remain elusive. In report, we characterized profile VAT-associated circulating innate lymphocyte regulatory T (Treg) cell subsets underlying conditions, such as obesity...
It has been demonstrated that α-synuclein can aggregate and contribute to the pathogenesis of some neurodegenerative diseases it is capable hindering autophagy in neuronal cells. Here, we investigated implication process primary human T lymphocytes. We provide evidence that: (i) knocking down gene resulted increased autophagy, (ii) induction by energy deprivation was associated with a significant decrease levels, (iii) inhibition 3-methyladenine or ATG5 led increase (iv) impairment,...
Current evidence indicates that estrogens, in particular 17β-estradiol (E2), play a crucial role the gender bias of autoimmune diseases although underlying molecular mechanisms have not yet been fully elucidated. Immune cells estrogen receptors (ERs), i.e., ERα and ERβ, pro- anti-inflammatory functions, respectively, presence one receptor (ER) subtype over other might change effects, promoting or dampening inflammation. In this study, we contributed to define influences E2 on T from female...
Estrogens, in particular 17β-estradiol (E2), have a strong influence on the immune system and also affect pathological conditions such as autoimmune diseases. The biological effects of E2 are mediated by two intracellular receptors, i.e., estrogen receptor (ER)α ERβ, which function ligand-activated nuclear transcription factors producing genomic effects. Immune cells express both ERα ERβ that play complex role modulating inflammation. Phytoestrogens display estrogen-like Among them,...
Diesel exhaust particles (DEP) are major constituents of ambient air pollution and their adverse health effect is an area intensive investigations. With respect to the immune system, DEP have attracted significant research attention as a factor that could influence allergic diseases interfering with cytokine production chemokine expression. this exception, scant data available on impact lymphocyte homeostasis. Here, effects nanoparticles from Euro 4 (E4) 5 (E5) light duty diesel engines...
Primary Sjögren's syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. In the current study, we aimed to investigate possible pathogenic implication autophagy in T lymphocytes patients with pSS. Thirty consecutive pSS were recruited together 20 affected sicca and/or sialoadenitis 30 healthy controls. Disease activity damage evaluated according SS index, EULAR index. analyzed for expression...
// Marina Pierdominici 1, * , Angela Maselli 2, Silvia L. Locatelli 3 Laura Ciarlo 2 Giuseppa Careddu Mario Patrizio Barbara Ascione Antonella Tinari 4 Carmelo Carlo-Stella Walter Malorni Paola Matarrese ** Elena Ortona 1 Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy Therapeutic Research Medicine Evaluation, Oncology Hematology, Humanitas Cancer Center - Clinical Center, Milano, Technology Health, These authors have contributed equally to this work...