A5031963462- HIV Research and Treatment
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- LGBTQ Health, Identity, and Policy
- Healthcare Regulation
- Education during COVID-19 pandemic
- Glycosylation and Glycoproteins Research
- Respiratory viral infections research
- Maternal and Neonatal Healthcare
- Antibiotic Resistance in Bacteria
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Infections and bacterial resistance
- T-cell and Retrovirus Studies
- Vasculitis and related conditions
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Kawasaki Disease and Coronary Complications
- Clostridium difficile and Clostridium perfringens research
- HIV-related health complications and treatments
- Atherosclerosis and Cardiovascular Diseases
Istituto Superiore di Sanità
2006-2025
Hospital de Clínicas de Porto Alegre
2022-2025
Universidade Federal do Rio Grande do Sul
2023
Leptin is an adipocyte-derived hormone/cytokine that links nutrition, metabolism, and immune homeostasis. capable of modulating several responses. However, the effect leptin on dendritic cells (DCs) has not yet been recognized. Because DCs are instrumental in development responses, this study, we evaluated impact DC activation. We demonstrated presence receptor human immature mature both at mRNA protein level its capacity to transduce signaling leading STAT-3 phosphorylation. found no...
Leptin is an adipocyte‐derived hormone/cytokine that modulates immune responses. It induces functional and morphological changes in human dendritic cells (DCs), licensing them towards Th1 priming promoting DC survival. Here we found leptin protects DCs from spontaneous, UVB H 2 O ‐induced apoptosis, by triggering the activation of nuclear factor‐kappa B (NF‐kB) a parallel up‐regulation bcl‐2 bcl‐XL gene expression Akt activation. We activates PI3K‐Akt signaling pathway as demonstrated...
Abstract CpG ODN drives B cells to differentiate into plasma cells; IFN-α amplifies the inductive effect of on cells. TLRs are a family molecules that function as sensors for detection pathogens. TLR-9, expressed and pDCs, recognizes motifs unmethylated bacterial DNA plays role in development autoimmunity. The present study was designed investigate effects combination with activation CD27– naïve Ig production. We provide evidence not only induces total T-dependent, specific IgM response by...
Background and Purpose Propranolol is a vasoactive drug that shows antiangiogenic antitumour activities in melanoma. However, it unknown whether these are dose‐dependent there relationship between systemic vascular effects of propranolol anti‐melanoma activity. Experimental Approach Effects increasing doses (10, 20, 30 40 mg·kg −1 ·day ) on tumour growth were studied B16F10 melanoma‐bearing mice. Histological biochemical analyses used to assess angiogenesis cancer cell proliferation....
The accessory HIV-1 Nef protein plays a key role in AIDS pathogenesis. We recently demonstrated that exogenous triggers phenotypic and functional differentiation of immature dendritic cells (DCs). Here we investigated whether the Nef-induced DC occurs with morphological remodeling have focused on interference signaling pathways regulates maturation. found enters DCs, promoting their differentiation. Specifically, promotes interleukin (IL) -12 release, which closely fits nuclear factor (NF)...
Leptin is an adipocyte-derived hormone/cytokine that links nutrition, metabolism, and immune homeostasis endowed to modulate several responses. We previously demonstrated both immature mature human dendritic cells (DCs) express a functional leptin receptor, we found activates DCs, licenses them for Th1 priming, promotes DC survival. Moreover, induces rearrangement of actin microfilaments, leading uropod ruffle formation. Here monitor the effects on migratory capacities, focusing...
The aim of the present work was to evaluate contribution different reactive oxidizing species systemic oxidative stress in whole blood patients with Kawasaki disease (KD). This is a rare generalized vasculitis typical early childhood characterized by inflammation and endothelial dysfunction high risk for cardiovascular fatal events. We found that, compared age-matched healthy donors, from KD showed increased production oxygen- nitrogen-derived as detected electron paramagnetic resonance...
Transgender and gender-diverse (TGD) individuals continue to experience harassment discrimination across various aspects of life, significantly impacting their physical mental health. The scarcity data on general health, particularly regarding dietary habits, remains a challenge in developing effective healthcare strategies for this population. To address gap, we analyzed selected activity (PA), body mass index (BMI) among Italian TGD adults compared the population (IGP). An online anonymous...
The accessory HIV-1 Nef protein is a crucial determinant for viral replication and pathogenesis. During HIV infection, loss of immune control in the setting strong broad HIV-specific T-lymphocyte response, leads to lethal outcome through AIDS. Moreover, dysfunction dendritic cells (DCs) may contribute suppression associated with AIDS progression. We recently demonstrated that exogenous selectively activates immature DCs manipulating their phenotypical, morphological, functional developmental...
Summary Kawasaki disease (KD) is an acute vasculitis affecting mainly infants and children. Human B cells express Toll-like receptor (TLR)-9, whose natural ligands are unmethylated cytosine–guanine dinucleotide (CpG) motifs characteristic of bacterial DNA. The aim this study was to clarify the pathogenesis KD analysing activation status peripheral blood mononuclear (PBMC), focusing on lymphocyte functions. Ten patients 10 age-matched healthy donors were recruited from Bambino Gesù Hospital...
Dendritic cells (DCs) and natural killer (NK) are essential components of the innate immunity play a critical role in first phase host defense against infection. Interactions between DCs NK have been demonstrated variety settings, with evidence emerging complex bidirectional crosstalk two cell types. The accessory HIV-1 Nef protein is crucial determinant for viral replication pathogenesis. We previously that Nef, hijacking DC functional activity, subverts arm immune response to escape...
Background The mucosal tissues play a central role in the transmission of HIV-1 infection as well pathogenesis AIDS. Despite several clinical studies reported intestinal dysfunction during HIV infection, mechanisms underlying HIV-induced impairments epithelial barrier are still unclear. It has been postulated that alters enterocytic function and proteins have detected cell types mucosa. In present study, we analyzed effect accessory Nef protein on human line. Methodology/Principal Findings...
SUMMARY We investigated the effect of N-acetylcysteine (NAC) on normal human B cell functions. found that NAC significantly inhibited both induction specific antibody response to T-dependent antigen Candida albicans and pokeweed mitogen (PWM)-induced polyclonal Ig production. did not induce either death due a non-specific toxicity or apoptosis. The NAC-induced inhibitory might be functional consequence of: (i) down-regulation expression surface CD40 CD27 co-stimulatory molecules (ii)...