A5045636723- Receptor Mechanisms and Signaling
- Blood donation and transfusion practices
- Plant Physiology and Cultivation Studies
- Nematode management and characterization studies
- Blood transfusion and management
- Blood groups and transfusion
- Hepatitis B Virus Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Plant Virus Research Studies
- Hemoglobinopathies and Related Disorders
- Mosquito-borne diseases and control
- Cardiac Ischemia and Reperfusion
- Liver Disease and Transplantation
- Phytoplasmas and Hemiptera pathogens
- Industrial Gas Emission Control
- Viral Infections and Vectors
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Banana Cultivation and Research
- Hemophilia Treatment and Research
- Complement system in diseases
- Hepatitis C virus research
- Agricultural Practices and Plant Genetics
- Pharmacological Effects and Assays
Istituto Superiore di Sanità
1999-2021
National Blood Transfusion Service
2010
Marche Polytechnic University
2010
The Chikungunya virus (CHIKV) is transmitted by Aedes mosquitoes and recently caused a massive epidemic on La Réunion Island, in the Indian Ocean. Between July September 2007 it first autochthonous outbreak Europe, Region of Emilia-Romagna north-east Italy.After reports an unusually high number patients with febrile illness unknown origin two contiguous villages, investigation was carried out to identify primary source infection, modes transmission dynamics epidemic. An active surveillance...
Background and Purpose Propranolol is a vasoactive drug that shows antiangiogenic antitumour activities in melanoma. However, it unknown whether these are dose‐dependent there relationship between systemic vascular effects of propranolol anti‐melanoma activity. Experimental Approach Effects increasing doses (10, 20, 30 40 mg·kg −1 ·day ) on tumour growth were studied B16F10 melanoma‐bearing mice. Histological biochemical analyses used to assess angiogenesis cancer cell proliferation....
In Italy nucleic acid testing (NAT) became mandatory for hepatitis C virus (HCV) in 2002 and human immunodeficiency (HIV) B 2008. The aim of this study was to monitor the incidence prevalence HIV HCV infections Italian blood donors current residual risk these after introduction NAT.The national surveillance system includes data from tests used screen transfusion-transmissible infections. During period survey (2009-2015), NAT methods were transcription-mediated amplification test, individual...
Huanglongbing (HLB) is a serious disease of citrus worldwide. Three different 'Candidatus Liberibacter' species are associated with HLB: 'Ca. Liberibacter asiaticus', L. africanus', and americanus' (1). africanus' its vector, Trioza erytreae, both heat sensitive, when present, occur in temperatures remain below 30 to 32°C. In Africa, T. erytreae have been reported South Zimbabwe, Malawi, Burundi, Kenya, Somalia, Ethiopia, Cameroon, Madagascar Inspection trees orchards budwood sources...
In Italy, the use of nucleic acid testing for hepatitis B virus (HBV) in donor screening has allowed detection infections window phase, as well presence occult which could potentially be transmitted. The aim this study was to analyse trends epidemiological data focused on HBV infection blood donors and estimate residual risk transmitting from both phase over a 10-year period Italy.Data were obtained Italian Haemovigilance System includes results tests transfusion transmissible infections....
Recent results indicate that the reduction of β-adrenergic signaling impairs angiogenesis under ischemic conditions. Because may occur in absence ischemia, it remains to be determined whether and how regulates angiogenesis, which develops normoxic The effect ligands on was investigated using 3-dimensional cultures mouse aortic rings embedded collagen type I, luminized microvessels develop response vascular endothelial growth factor (VEGF). Under conditions, both isoproterenol, a receptor...
Iron homeostasis in humans is tightly regulated by mechanisms aimed to conserve iron for reutilisation, with a negligible role played excretory mechanisms. In previous study we found that mice have an astonishing ability tolerate very high doses of parenterally administered dextran. Whether this linked the existence pathway remains be ascertained.Iron overload was generated intraperitoneal injections dextran (1 g/kg) once week 8 weeks two different mouse strains (C57bl/6 and B6D2F1). Urinary...
Cardiac hypertrophy is a homeostatic response to elevated afterload. Na + /H exchanger (NHE) inhibition reduces the hypertrophic in animal models of left ventricular (LVH) and myocardial infarction. We examined effect chronic treatment with cariporide, selective inhibitor isoform 1 (NHE‐1), on (LV) systolic diastolic function under pressure overload conditions. Male CD‐1 mice were randomized receive either control diet or an identical supplemented 6000 p.p.m. cariporide. was induced by...
Pathological cardiac hypertrophy is associated with the expression of a gene profile reminiscent foetal development. The non selective beta-adrenoceptor antagonist propranolol able to blunt cardiomyocyte hypertrophic response in pressure-overloaded hearts. It remains be determined whether also attenuates hypertrophy-associated genes.To address this question, programme, which atrial natriuretic peptide (ANP), beta-isoform myosin heavy chain (beta-MHC), and alpha-skeletal muscle isoform actin...
Haemovigilance is defined as the surveillance of adverse reactions occurring in donors and recipients blood components epidemiological donors. The ultimate purpose haemovigilance to prevent repetition events reactions. Since 2002/98/EC Directive came into force, introduction systems has become a priority for all countries European Community. Italian system essentially line with Directive, although it does not include have national level registration severe incidents connected collection,...
Cardiac hypertrophy arises as an adaptive response to increased afterload. Studies in knockout mice have shown that catecholamines, but not alpha1-adrenergic receptors, are necessary for such adaptation occur. However, whether beta-adrenergic receptors critical the development of cardiac pressure overload is known at this time.Pressure was induced by transverse aortic banding beta1-adrenergic and beta2-adrenergic receptor double (DbetaKO) mice, which predominant subtypes lacking. Chronic 4...
BACKGROUND AND PURPOSE Cell cycle regulators are regarded as essential for cardiomyocyte hypertrophic growth. Given that the β-adrenoceptor antagonist propranolol blunts growth, we determined whether alters expression of cell cycle-related genes in mouse hearts subjected to pressure overload. EXPERIMENTAL APPROACH Pressure overload was induced by transverse aortic constriction (TAC), whereas levels 84 were assayed real-time PCR. Propranolol (80 mg·kg−1·day−1) administered drinking water 14...
Chronic transfusion therapy causes a progressive iron overload that damages many organs including the heart. Recent evidence suggests L-type calcium channels play an important role in uptake by cardiomyocytes under conditions of overload. Given beta-adrenergic stimulation significantly enhances current, we hypothesised blocking drugs could reduce deleterious effects on heart.Iron was generated intraperitoneal injections dextran (1g/kg) administered once week for 8 weeks male C57bl/6 mice,...