A5062205577- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Diverticular Disease and Complications
- Biosimilars and Bioanalytical Methods
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders
- Esophageal and GI Pathology
- Tuberculosis Research and Epidemiology
- Genetic factors in colorectal cancer
- Diagnosis and treatment of tuberculosis
- Radiomics and Machine Learning in Medical Imaging
- Vitamin D Research Studies
- Liver Diseases and Immunity
- Infectious Diseases and Tuberculosis
- Celiac Disease Research and Management
- Metastasis and carcinoma case studies
- Mycobacterium research and diagnosis
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Colorectal Cancer Treatments and Studies
Ospedale Regina Margherita
2015-2024
Gastroenterology Hospital "Saverio de Bellis"
2024
ASL Roma
2022
Ospedale San Filippo Neri
2021
RELX Group (Netherlands)
2020
Ospedale di Santo Spirito
2018
University of Padua
2013
Istituti di Ricovero e Cura a Carattere Scientifico
2012
Hospital Israelita Albert Einstein
2011
Artificial intelligence (AI) may detect colorectal polyps that have been missed due to perceptual pitfalls. By reducing such miss rate, AI increase the detection of neoplasia leading a higher degree cancer (CRC) prevention.Patients undergoing CRC screening or surveillance were enrolled in 8 centers (Italy, UK, US), and randomized (1:1) undergo 2 same-day, back-to-back colonoscopies with without (deep learning computer aided diagnosis endoscopy) different arms, namely followed by colonoscopy...
Artificial Intelligence (AI) could support cost-saving strategies for colonoscopy because of its accuracy in the optical diagnosis colorectal polyps. However, AI must meet predefined criteria to be implemented clinical settings.An approved computer-aided (CADx) module differentiating between adenoma and nonadenoma unmagnified white-light was used a consecutive series colonoscopies. For each polyp, CADx output subsequent endoscopist with advanced imaging were matched against histology gold...
Gastric cancer remains the second most frequent cause of cancer-related mortality in world. Screening programs some Asian countries are impractical majority other worldwide. Therefore, follow-up precancerous lesions is advisable for secondary gastric prevention. Intestinal metaplasia (IM) recognized as a lesion cancer, increasing risk by 6-fold. IM highly prevalent general population, being detected nearly 1 every 4 patients undergoing upper endoscopy. The prevalence rate significantly...
// Marina Pierdominici 1 , Angela Maselli 2 Barbara Varano 3 Cristiana Barbati Paola Cesaro 4 Cristiano Spada Angelo Zullo 5 Roberto Lorenzetti Marco Rosati 6 Gabriella Rainaldi Maria Rosaria Limiti Luisa Guidi 7 Lucia Conti 3,* and Sandra Gessani Department of Cell Biology Neurosciences, Istituto Superiore di Sanità, Rome, Italy Therapeutic Research Medicines Evaluation, Hematology, Oncology Molecular Medicine, Digestive Endoscopy Unit, Catholic University, Gastroenterology...
In this study, we aimed to characterize the SARS-CoV-2-specific T cell response detected by QuantiFERON SARS-CoV-2 research use only assay in terms of accuracy and subsets involved compared with a homemade interferon (IFN)-γ release (IGRA).We evaluated standardized tubes (antigen [Ag]1 Ag2) IGRA quantifying IFN-γ spike peptides (homemade-IGRA-SPIKE test). We mediating specific using flow cytometry.We prospectively enrolled 66 individuals: COVID-19 or post-COVID-19 subjects...
Background Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist recently approved for treating ulcerative colitis (UC) but with limited real-world data. Therefore, we evaluated the effectiveness and safety of UST in patients UC a setting.
Abstract Background Adalimumab (ADA) biosimilars have entered the therapeutic armamentarium of inflammatory bowel disease (IBD), allowing for treatment a greater number patients their reduced cost than originator. However, comparative data on efficacy and safety various ADA remains scarce. We compare SB5, ABP501, GP2017, MSB11022 in treating IBD outpatients real-life Italian setting. Methods A retrospective analysis was performed consecutive with complete clinical, laboratory, endoscopic...
We estimated the extent of inflammatory mucosal lesion by colonoscopy and biopsy in 60 patients with their first attack ulcerative colitis. Proctitis was found 12, proctosigmoiditis 19, left-sided colitis 10, extensive 19. Fourteen clinical variables laboratory measurements (bowel frequency, stool consistency, rectal bleeding, fecal mucus/pus, temperature, pulse rate, white blood cell count, hematocrit, sedimentation serum iron, albumin, alpha 2-globulin, C-reactive protein, seromucoids)...
Infliximab and adalimumab are widely used for the treatment of Crohn's disease ulcerative colitis.To compare long-term efficacy safety infliximab in a large cohort colitis patients reflecting real-life clinical practice.Seven hundred twelve were retrospectively reviewed, 410 with (268 treated 142 infliximab; median follow-up 60 months, range, 36-72) 302 (118 184 48 36-84).In disease, remission was maintained 75.0% vs. 72.5% (P = 0.699); mucosal healing steroid-free 49.5% 63.9% 0.077) 77.7%...
Golimumab (GOL) has been recently approved in Italy for the treatment of ulcerative colitis (UC) unresponsive to standard treatments. Our aims were assess real-life efficacy and safety GOL managing UC outpatients Italian primary Inflammatory Bowel Diseases (IBD) centres.Consecutive with at least 3-months follow-up enrolled. Primary end-point was induction maintenance remission UC, defined as Mayo score </=2, 6-month follow-up.Ninety-three patients At follow-up, obtained 34 (36.5%) patients....
Background : Following standard triple therapy, up to 20% of patients require further Helicobacter pylori eradication treatment. Data regarding the efficacy re‐treatment in these are scarce. Aim To evaluate a therapy after one or more consecutive treatment failures. Methods A total 51 with persistent H. infection at least unsuccessful 1‐week regimen were enrolled study. entry was assessed by rapid urease test and histology on biopsies from antrum corpus. Patients given 2‐week comprising...
Background and Aims: Adalimumab (ADA) biosimilars have been included into the therapeutic armamentarium of inflammatory bowel disease (IBD); however, comparative data on efficacy safety different ADA after replacing originator for a non-medical reason remains scarce. We aimed to compare in real-life setting four SB5, APB501, GP2017, MSB11022 IBD patients reason.
 Methods: A multicenter retrospective study was performed consecutive patients, analyzing clinical, laboratory, endoscopic...
Chronic nonbloody diarrhea (CND) is a frequent intestinal disorder, with relevant economic impact. Besides colonic diseases, alterations of the terminal ileum could be involved in CND pathogenesis. The aim this study was to assess role retrograde ileoscopy biopsy patients.Patients complaining and matched control subjects were enrolled study. Retrograde attempted all cases. Endoscopic histological features Crohn's disease, nonspecific ileitis, nodular lymphoid hyperplasia recorded for each...