A5036454326- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Erythrocyte Function and Pathophysiology
- Head and Neck Anomalies
- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Neonatal Health and Biochemistry
- Kawasaki Disease and Coronary Complications
- Ion channel regulation and function
- Metabolomics and Mass Spectrometry Studies
- Fatigue and fracture mechanics
- Hemoglobin structure and function
- Vasculitis and related conditions
- Glutathione Transferases and Polymorphisms
- Cancer, Hypoxia, and Metabolism
- Ultrasonics and Acoustic Wave Propagation
- Neuroscience and Neuropharmacology Research
- Cancer Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Coronary Artery Anomalies
- Surgical Simulation and Training
- Lymphatic System and Diseases
- Colorectal Cancer Surgical Treatments
- Inflammasome and immune disorders
- Ultrasound Imaging and Elastography
Policlinico Umberto I
2017-2021
Sapienza University of Rome
2002-2021
Istituto Superiore di Sanità
2006-2014
Oxidative stress is responsible for some alterations in the chemical structure and, consequently, function of proteins, lipids, and DNA. Recent studies have linked oxidative to cancers, particularly thyroid cancer, but mechanisms remain unclear. Here, we further characterize role cancer by analyzing expression two selenium antioxidant molecules, glutathione peroxidase (GPx1) thioredoxin reductase (TrxR1) cells. Samples both healthy tissue tumor were taken analysis after total thyroidectomy....
Endothelial dysfunction has been detected in RA patients and seems to be reversed by control of inflammation. Low circulating endothelial progenitor cells (EPCs) have described many conditions associated with increased cardiovascular risk, including RA. The aim this study was investigate the effect inhibition TNF on EPCs patients. Seventeen moderate-severe 12 sex age-matched controls were evaluated. biomarkers tested at baseline after 3 months. identified from peripheral blood mononuclear...
The small protein Bv8, isolated from amphibian skin, belongs to a novel family of secretory proteins (Bv8‐Prokineticin family, SWISS‐PROT: Q9PW66) whose orthologues have been conserved throughout evolution, invertebrates humans. When injected intravenously or subcutaneously (from 0.06 500 pmol kg −1 ) intrathecally 6 fmol 250 pmol) in rats, Bv8 produced an intense systemic nociceptive sensitization mechanical and thermal stimuli applied the tail paws. Topically delivered into one rat paw, 50...
Objectives . Impaired endothelial function represents the early stage of atherosclerosis, which is typically associated with systemic inflammatory diseases like rheumatoid arthritis (RA). As modulators nitric oxide synthase expression, asymmetric-dimethylarginine (ADMA) and apelin might be measured in blood RA patients to detect atherosclerotic changes. We conducted a prospective, case-control study investigate serum ADMA profiles early-stage (ERA) before after disease-modifying...
The aim of the present work was to evaluate contribution different reactive oxidizing species systemic oxidative stress in whole blood patients with Kawasaki disease (KD). This is a rare generalized vasculitis typical early childhood characterized by inflammation and endothelial dysfunction high risk for cardiovascular fatal events. We found that, compared age-matched healthy donors, from KD showed increased production oxygen- nitrogen-derived as detected electron paramagnetic resonance...
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity in Western countries. The increased oxidative stress, caused by the release reactive oxygen and nitrogen species (ROS/RNS) from inflammatory airways cells, contributes to pathogenesis disease. aim present study was evaluate (a) whether imbalance can lead specific alterations red blood cells (RBCs) stable COPD patients; (b) treatment with N-acetyl-cysteine (NAC), widespread use as mucolytic agent clinical practice,...
Aims: The biochemistry underlying the physiological, adaptive, and toxic effects of carbon monoxide (CO) is linked to its affinity for reduced transition metals. We investigated CO signaling in vasculature, where hemoglobin (Hb), most important metal-containing carrier highly concentrated inside red blood cells (RBCs). Results: By combining NMR, MS, spectrophotometric techniques, we found that treatment whole increases concentration glutathione (GSH) RBC cytosol, which a significant Hb...
Thyroid cancer cells demonstrate an increase in oxidative stress and decreased antioxidant action, but the effects of this increased on cell function remain unknown. We aimed to identify changes metabolism thyroid caused by stress, using proton nuclear magnetic resonance (1H-NMR) spectroscopy. Samples healthy tissue were collected from patients undergoing thyroidectomy analyzed with 1H-NMR spectroscopy for a wide array metabolites. found significant lactate content compared tissue....
Abstract Postmarketing Phase IV Chronic inflammatory diseases such as rheumatoid arthritis ( RA ) are associated with accelerated atherosclerosis and increased morbidity mortality for cardiovascular events. Asymmetric dimethyl arginine ADMA ), an endogenous inhibitor of nitric oxide synthase, contributes to the impairment endothelial function, earlier reversible stage atherosclerotic plaque formation. Since tumor necrosis factor TNF inhibits enzymatic degradation , anti‐ agents could restore...
Background and Objectives: The surgical choice treatment of the breast cancer mostly depends on stage disease. In last years, surgery has moved from being destructive to more respectful anatomical physiological integrity gland. aim should be finalized obtain best aesthetic functional results, respecting principles oncologic radicality. present study is a retrospective analysis aimed evaluate long-term outcomes conservative technique like nipple-sparing mastectomy. Materials Methods: We...
High concentrations of free radicals are present in the blood obese patients. Free associated with endothelial dysfunction, diabetes, and neoplastic transformation, all conditions that closely related to obesity. The purpose our study was determine whether bariatric surgery modifies production In total, 20 patients morbid obesity, who were candidates for laparoscopic sleeve gastrectomy (SG), 18 controls enrolled study. Oxidative stress studied subjects before after gastrectomy. evaluation...
Post-thyroidectomy hypocalcemia is a frequent complication with significant morbidity, and has been shown to increase hospital stay readmission rates. The evaluation of serum parathyroid hormone (PTH) levels after thyroidectomy represents reliable method predict post-thyroidectomy hypocalcemia, but it remains infrequently used. This retrospective study investigates PTH values 3 h as predictor hypocalcemia. In this study, we enrolled 141 patients aged between 27 71 years eligible for total...