A5053740113- Erythrocyte Function and Pathophysiology
- Kawasaki Disease and Coronary Complications
- Sex and Gender in Healthcare
- Antioxidant Activity and Oxidative Stress
- Skin Protection and Aging
- Blood properties and coagulation
- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Coronary Artery Anomalies
- Fullerene Chemistry and Applications
- Neonatal Health and Biochemistry
- Atherosclerosis and Cardiovascular Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Vasculitis and related conditions
- HIV Research and Treatment
- ATP Synthase and ATPases Research
- PARP inhibition in cancer therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Long-Term Effects of COVID-19
- Adipose Tissue and Metabolism
- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Free Radicals and Antioxidants
- Phytochemicals and Antioxidant Activities
Istituto Superiore di Sanità
2016-2025
University of L'Aquila
2000
University of Perugia
2000
Sapienza University of Rome
1994
Azienda Unita' Sanitaria Locale Di Modena
1994
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
1993
Leptin is an adipocyte-derived hormone/cytokine that links nutrition, metabolism, and immune homeostasis. capable of modulating several responses. However, the effect leptin on dendritic cells (DCs) has not yet been recognized. Because DCs are instrumental in development responses, this study, we evaluated impact DC activation. We demonstrated presence receptor human immature mature both at mRNA protein level its capacity to transduce signaling leading STAT-3 phosphorylation. found no...
During their lifespan, red blood cells (RBCs) are exposed to a large number of stressors and therefore considered as suitable model investigate cell response oxidative stress (OS). This study was conducted evaluate the potential beneficial effects natural antioxidant quercetin (Q) on an OS represented by human RBCs treated with H2O2. Markers OS, including % hemolysis, reactive oxygen species (ROS) production, thiobarbituric acid substances (TBARS) levels, oxidation protein sulfhydryl groups,...
Mercury is a toxic heavy metal widely dispersed in the natural environment. exposure induces an increase oxidative stress red blood cells (RBCs) through production of reactive species and alteration endogenous antioxidant defense system. Recently, among various antioxidants, polyphenols from extra-virgin olive oil (EVOO), important element Mediterranean diet, have generated growing interest. Here, we examined potential protective effects hydroxytyrosol (HT) and/or homovanillyl alcohol (HVA)...
Aging is a process characterised by general decline in physiological functions. The high bioavailability of reactive oxygen species (ROS) plays an important role the aging rate. Due to close relationship between and oxidative stress (OS), functional foods rich flavonoids are excellent candidates counteract age-related changes. This study aimed verify protective Açaì extract d-Galactose (d-Gal)-induced model human erythrocytes. Markers OS, including ROS production, thiobarbituric acid...
Red blood cell (RBC) deformability is the ability of cells to modulate their shape ensure transit through narrow capillaries microcirculation. A loss can occur in several pathological conditions, during natural RBC aging an increase membrane protein phosphorylation, and/or structural rearrangements cytoskeletal proteins due oxidative with a key role played by band 3. Due close relationship between and stress, flavonoid-rich foods are good candidates counteract age-related alterations. This...
Introduction: Aging is a process characterised by decline in physiological functions. Reactive species play crucial role the aging rate. Due to close relationship between and oxidative stress, functional foods rich phytochemicals are excellent candidates neutralise age-related changes. Aim: This investigation aims verify potential protective of bergamot ( Citrus bergamia , Femminello cultivar) peel juice extract model represented human red blood cells (RBCs) exposed D-Galactose (DGal)....
Plastic material versatility has resulted in a substantial increase its use several sectors of our everyday lives. Consequently, concern regarding human exposure to nano-plastics (NPs) and micro-plastics (MPs) recently increased. It been shown that plastic particles entering the bloodstream may adhere erythrocyte surface exert adverse effects following aggregation adhesion blood vessels. Here, we explored polystyrene (PS-NPs) (PS-MPs) on erythrocytes. Cellular morphology,...
Changes in the oxidative status of erythrocytes can reduce cell lifetime, oxygen transport, and delivery capacity to peripheral tissues have been associated with a plethora human diseases. Among reactive nitrogen species importance red blood (RBC) homeostasis, superoxide nitric oxide radicals play key role. In present work, we evaluated subcellular effects induced by peroxynitrite, product fast reaction between oxide. Peroxynitrite 1) oxidation oxyhemoglobin methemoglobin, 2) cytoskeleton...
Abstract The effects of a 50‐Hz extremely low frequency magnetic field on cultured K562 cells growing in suspension were studied by means scanning electron microscopy and paramagnetic resonance spectroscopy. Exposure at 2.5 mT for periods to 96 hours induced significant changes cell‐surface structure physiology without modification proliferative capability as indicated quantitative analysis. Thus fields seem able induce injurious, sublethal cell alterations, the plasma membrane seems play an...
Vascular smooth muscle cells (VSMC) have been isolated from male and female rat aorta studied to assess their susceptibility ultraviolet radiation‐induced oxidative stress. Interestingly, a gender difference, in terms of reactive oxygen species production, was detected both basal irradiated VSMC. Namely, VSMC rats were more susceptible stress easier underwent apoptosis comparison rats. Conversely, the latter, same experimental conditions, clearly displayed signs premature senescence. These...
β-thalassemia, a hereditary hemoglobinopathy, is caused by reduced or absent synthesis of the β-globin chains hemoglobin. Three clinical conditions are recognized: β-thalassemia major, intermedia, and minor (β-Thal+). This latter condition occurs when an individual inherits mutated gene from one parent. In erythrocytes β-Thal+ subjects, excess α-globin produce unstable α-tetramers, which can induce substantial oxidative stress leading to plasma membrane cytoskeleton damage, as well deranged...
Gender medicine is a multi-faceted field of investigation integrating various aspects psycho-social and biological sciences but it mainly deals with the impact gender on human physiology, pathophysiology, clinical features diseases. In Italy, Decree Law 81/2008 recently introduced issue in risk assessment at workplaces. This review briefly describes our current knowledge Italian legislation management. Public or private scientific institutions should be first to pay attention safety their...
In mice, the Fas/Fas ligand (FasL) system has been shown to be involved in germ cell apoptosis. present study we evaluated expression of Fas and fetal adult human testis. Semiquantitative RT-PCR demonstrated FasL messenger ribonucleic acids testis, but not testis (20-22 weeks gestation). situ immunohistochemistry experiments on acid protein Sertoli Leydig cells, whereas was confined cells sporadic degenerating spermatocytes. The number Fas-positive per 100 nuclei increased 10 biopsies with...