A5009200286- Thyroid Cancer Diagnosis and Treatment
- Sinusitis and nasal conditions
- Thyroid and Parathyroid Surgery
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Head and Neck Anomalies
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Mechanisms of cancer metastasis
- Allergic Rhinitis and Sensitization
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Tracheal and airway disorders
- Cell Adhesion Molecules Research
- Voice and Speech Disorders
- Neuroendocrine Tumor Research Advances
- Carcinogens and Genotoxicity Assessment
- Radiomics and Machine Learning in Medical Imaging
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2003-2024
University of Fribourg
2024
University of Padua
2012-2021
University of Brescia
2010-2015
Ospedale Israelitico
2015
Cefriel
2013
Istituto Oncologico Veneto
2007-2012
Azienda Ospedaliera di Padova
2006-2011
Surgical Specialties (United States)
2011
The available classifications of gastritis are inconsistently used, possibly because none provides immediate prognostic/therapeutic information to clinicians. As histology reporting hepatitis in terms stage is clinically useful and widely accepted, an international group (Operative Link on Gastritis Assessment (OLGA)) proposed equivalent staging system for gastric histology. integrates the atrophy score (obtained by biopsy) topography (achieved through directed biopsy mapping).To test a...
The current use of life-long follow-up in patients with papillary thyroid cancer (PTC) is based largely on the study individuals diagnosed and treated latter half 20th century when recurrence rates were approximately 20% relapses detected up to 20-30 years after surgery. Since then, however, diagnosis, treatment, postoperative monitoring PTC have evolved significantly.The objective was identify times by which these occurred a more recent patient cohort.We retrospectively analyzed data for...
Abstract Context The prevalence of thyroid nodules in the general population is increasingly high, and at least half those biopsied prove to be benign. Sonographic risk-stratification systems are being proposed as “rule-out” tests that can identify do not require fine-needle aspiration (FNA) cytology. Objective To comparatively assess performances five internationally endorsed sonographic classification [those American Thyroid Association, Association Clinical Endocrinologists, College...
Intestinal-type gastric cancer (GC) still ranks among the high-incidence, highly lethal malignancies. Atrophic gastritis is cancerization field in which GC develops. The current histological reporting formats for do not include any (atrophy-based) ranking of risk.To test OLGA-staging (Operative Link Gastritis Assessment) prognosticating neoplastic progression.Ninety-three Italian patients were followed up more than 12 years (range: 144-204 months). Clinical examinations, pepsinogen serology,...
Abstract Summary: Controlled polymerization of N ‐isopropylacrylamide (NIPAAM) was achieved by atom transfer radical (ATRP) using ethyl 2‐chloropropionate (ECP) as initiator and CuCl/tris(2‐dimethylaminoethyl)amine (Me 6 TREN) a catalytic system. The carried out in DMF:water 50:50 (v/v) mixed solvent at 20 °C. first order kinetic plot linear up to 92% conversion. molecular weights 2.2 × 10 4 low polydispersities (1.19) were obtained. living character the also demonstrated self‐blocking...
The frequency of micronuclei resulting from chromosome breaks, and that deriving spindle disturbances was determined in exfoliated cells the human buccal mucosa 50 normal individuals. Several confounding factors, such as age, smoking habits, alcohol consumption, etc., were taken into account. While frequencies breaks with this kind about double smokers compared non-smokers, difference being highly statistically significant, almost same two groups. No significant correlation found for any...
MicroRNA-221 (miR-221) is one of the most frequently and consistently up-regulated microRNAs (miRNAs) in human cancer. It has been hypothesized that miR-221 may act as a tumor promoter. To demonstrate this, we developed transgenic (TG) mouse model exhibits an inappropriate overexpression liver. Immunoblotting immunostaining confirmed concomitant down-regulation target proteins. This TG characterized by emergence spontaneous nodular liver lesions approximately 50% male mice strong...
Serum thyroglobulin (Tg) assays are considered fundamental in postoperative surveillance of differentiated thyroid cancer (DTC) patients. However, the postsurgical profile Tg levels has never been specifically investigated patients who do not undergo radioiodine remnant ablation (RRA). Our objective was to explore evolution over time DTC treated with total or near-total thyroidectomy without RRA. We retrospectively analyzed 290 consecutively diagnosed cases low-risk (American Thyroid...
Background Galectin-3 (Gal-3) is an anti-apoptotic molecule involved in thyroid cells transformation. It specifically overexpressed tumour and currently used as a preoperative diagnostic marker of malignancy. Gal-3 expression downregulated by wt-p53 at the transcriptional level. In well-differentiated carcinomas (WDTCs) there unexplained paradoxical concomitant wt-p53. HIPK2 co-regulator different transcription factors, modulates basic cellular processes mainly through activation Since we...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Prognosis poor, and therapeutic options are limited. MicroRNAs (miRNAs) have emerged as potential molecules against cancer. Here, we investigated efficacy miR-199a-3p, an miRNA highly expressed in normal liver downregulated virtually all HCCs. The value miR-199a-3p mimic was assayed TG221 mouse, a transgenic model predisposed to development Administration mimics mouse showing cancer led significant...
Context: Most papillary thyroid microcarcinomas (PTMCs; ≤ 1 cm diameter) are indolent low-risk tumors, but some cases behave more aggressively. Controversies have thus arisen over the optimum postoperative surveillance of PTMC patients.
Obliterative portal venopathy without hypertension has been described by a single study in limited number of patients, thus very little is known about this clinical condition. This aimed to investigate the prevalence obliterative and its clinical-pathological correlations patients with cryptogenic chronic liver test abnormalities signs hypertension.We analysed 482 biopsies from adults non-cirrhotic disorders any hypertension, consecutively enrolled 5-year period. Twenty cases idiopathic...
Laryngeal squamous cell carcinoma (LSCC) prognosis is definitely related to lymph node metastasis. Epithelial-mesenchymal transition (EMT) allows neoplastic cells gain the plasticity and motility required for tumour progression The aim of this study was investigate role EMT in LSCC.Immunohistochemical analysis E-cadherin, N-cadherin, Snail, Slug, ZEB1, ZEB2 performed 37 consecutive LSCC cases. Low E-cadherin levels high Slug correlated with both disease recurrence (P = 0.02 P =0.01,...
Trends toward more conservative management of papillary thyroid cancer (PTC) diminish the primacy serum thyroglobulin (Tg) assays as a posttreatment surveillance tool. To identify tumor-associated microRNAs (miRNAs) in with potential for development unique biomarkers PTC recurrence. We measured expression 754 miRNAs samples collected from 11 patients before and 30 days after thyroidectomy. Major candidates were then re-evaluated by absolute quantitative polymerase chain reaction analysis an...
Background Predicting which patients are at a higher risk for recurrent chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most challenging problems in clinical rhinology. A direct association between CRSwNP recurrence rates and serum eosinophil basophil counts was reported. This study aimed to identify best‐fitting cutoffs binarizing preoperative eosinophils basophils (counts/percentages) prognostic purposes cases after surgery. secondary endpoint distinguish said...
Oxidative stress is responsible for some alterations in the chemical structure and, consequently, function of proteins, lipids, and DNA. Recent studies have linked oxidative to cancers, particularly thyroid cancer, but mechanisms remain unclear. Here, we further characterize role cancer by analyzing expression two selenium antioxidant molecules, glutathione peroxidase (GPx1) thioredoxin reductase (TrxR1) cells. Samples both healthy tissue tumor were taken analysis after total thyroidectomy....
Abstract Purpose To evaluate the diagnostic performance of strain ratio elastography (SRE) and shear wave (SWE) alone in combination with Thyroid Imaging Reporting Data System (TIRADS) classification parameters to improve differentiation between benign malignant thyroid nodules. Materials Methods In this prospective study (n = 191) 52) nodules were examined high-resolution ultrasound (US) features using TIRADS lexicon SRE semiquantitative SWE quantitative findings histology or cytology as...
Improving the prognosis of breast cancer patients is utmost importance in terms increasing survival rates. Modern medicine has therefore prioritized better quality life for patients, even after disease, through a management potential long-term side effects induced by anticancer treatments. Fertility preservation and family planning are crucial issues to be addressed all reproductive age. Along those lines, new branch with distinct multidisciplinary characteristics developed over years:...
Abstract The Aurora kinases are involved in the regulation of cell cycle progression, and alterations their expression have been shown to associate with malignant transformation. In present study, we demonstrated that human thyrocytes express all 3 (A, B C) at both protein mRNA level this is cycle‐regulated. An increase was found, respect normal (HTU5), lines derived from follicular (FTC‐133), papillary (B‐CPAP) anaplastic (8305C) thyroid carcinomas, but not cells a adenoma (HTU42). These...
Squamous cell carcinoma antigen (SCCA) is a serine protease inhibitor that can be overexpressed in hepatocellular (HCC) at both molecular and protein level, but no data are available on its expression pre-malignant stages.To assess SCCA by immunohistochemistry HCC nodular precursors cirrhotic livers.55 nodules from 42 explanted livers were evaluated: 7 large regenerative (LRNs), low-grade dysplastic (LG-DNs), 10 high-grade DNs (HG-DNs), 31 HCC. was semiquantitatively scored four-tiered...