A5085481958- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Global Cancer Incidence and Screening
- Advances in Oncology and Radiotherapy
- COVID-19 Clinical Research Studies
- RNA Interference and Gene Delivery
- COVID-19 and healthcare impacts
- Toxoplasma gondii Research Studies
- Congenital Anomalies and Fetal Surgery
- Virus-based gene therapy research
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- HIV/AIDS drug development and treatment
- Radiopharmaceutical Chemistry and Applications
- interferon and immune responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Thyroid Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Cervical Cancer and HPV Research
- Bacterial Genetics and Biotechnology
- COVID-19 Impact on Reproduction
- FOXO transcription factor regulation
- Biochemical and Molecular Research
- Viral-associated cancers and disorders
University of Ferrara
2013-2024
Ministry of Health and Medical Education
2021-2022
Jahrom University of Medical Sciences
2021
Alborz University of Medical Sciences
2021
Tehran University of Medical Sciences
2013-2020
The Ohio State University
2016-2018
National Institute of Genetic Engineering and Biotechnology
2017
Morpho (United States)
2016
Babol University of Medical Sciences
2015
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Prognosis poor, and therapeutic options are limited. MicroRNAs (miRNAs) have emerged as potential molecules against cancer. Here, we investigated efficacy miR-199a-3p, an miRNA highly expressed in normal liver downregulated virtually all HCCs. The value miR-199a-3p mimic was assayed TG221 mouse, a transgenic model predisposed to development Administration mimics mouse showing cancer led significant...
Hepatocellular carcinoma (HCC) is the most common liver cancer and second leading cause of related death worldwide. Most HCCs occur in a damaged cirrhotic background it may be difficult to discriminate between regenerative nodules early HCCs. No dependable molecular biomarker exists for detection HCC. MicroRNAs (miRNAs) have attracted attention as potential blood-based biomarkers. To identify circulating miRNAs with diagnostic HCC, we performed preliminary RNAseq studies on plasma samples...
Long noncoding RNAs (lncRNAs) are non-proten-coding transcripts of more than 200 nucleotides generated by RNA polymerase II and their expressions tightly regulated in cell type specific- and/or cellular differential stage manner. MIAT, originally isolated as a candidate gene for myocardial infarction, encodes lncRNA (termed MIAT). Here, we determined the expression level MIAT established leukemia/lymphoma lines found its upregulation lymphoid but not myeloid lineage with mature B phenotype....
The down-regulation of miR-199 occurs in nearly all primary hepatocellular carcinomas (HCCs) and HCC cell lines comparison with normal liver. We exploited this differential expression to develop a conditionally replication-competent oncolytic adenovirus, Ad-199T, achieve tumor-specific viral replication. To aim, we introduced four copies target sites within the 3' UTR E1A gene, essential for As consequence, from Ad-199T virus was tightly regulated both at RNA protein levels derived lines,...
microRNA miR-221 is frequently over-expressed in a variety of human neoplasms. Aim this study was to identify new gene targets improve our understanding on the molecular tumor-promoting mechanisms affected by miR-221. Gene expression profiling miR-221-transfected-SNU-398 cells analyzed Sylamer algorithm verify enrichment among down-modulated genes. This analysis revealed that enforced SNU-398 caused down-regulation 602 mRNAs carrying sequences homologous seed sequence within their 3'UTRs....
Hepatocellular carcinoma (HCC) is the most common liver cancer and among leading causes of cancer-related death worldwide. There no reliable biomarker for early diagnosis HCC. Circulating microRNAs (miRNAs) have attracted attention as potential biomarkers disease. By small-RNA next-generation sequencing, analysis serum miRNAs led to identification molecular signatures able discriminate advanced HCC from (n = 246); CIRRHOSIS 299); HEALTHY 320); 343); 414). Cirrhotic patients exhibited similar...
Annually, over 131000 new cases of cancer have been identified in Iran, with an increasing trend that is predicted to grow by 40% 2025. The most important contributing factors this increase are the improvement health service delivery system, increased life expectancy, and aging population. aim study was develop Iran's "National Cancer Control Program" (IrNCCP).The present a cross-sectional conducted 2013 using method reviewing studies documents focused group discussions panel experts. In...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Abstract Cancer patients are at risk for severe complications or death from COVID-19 infection. Therefore, the need routine testing in this population was evaluated. Between 1st August and 30th October 2020, 150 cancer were included. Symptoms of infection All eligible individuals went through RT-PCR serological tests COVID-19. At same time, 920 non-cancer recruited a random sample who subject to molecular anti-body screening tests. Of patients, 7 (4.7%) positive. Comorbidity made significant...
Iran was among countries which hard hit at the early stage of coronavirus disease 2019 (COVID-19) pandemic and dealt with second wave in May June 2020; however, there are a very limited number complete genome sequences acute respiratory syndrome 2 (SARS-CoV-2) from Iran. In this study, virus samples obtained three patients Alborz province 2020 were generated analyzed using bioinformatic methods. The sequenced genomes positioned cluster B.4 lineage along other namely, United Arab Emirates...
Background and Aim:The incidence rate of cancer in Iran is lower than the global average, but this increasing both world next two decades Materials Methods: "Iran National Cancer Control" was developed 2013 with a strategic planning approach consists 4 main processes 7 support processes.Results: Some significant interventions taken are: implementation training programs, vaccinations multi-sectoral collaboration to reduce burden risk factors, prevention component; breast, cervical colon...
Objective: Human papilloma virus (HPV) can be the aetiologic factor in benign or malignant oesophageal epithelium.Human is suspected of causing extragenital cancers, including: cancers oral cavity, larynx, oesophagus and lungs.More than 40 genotypes HPV that infect anogenital area are associated with a large spectrum diseases from proliferation to invasive cancers.The aims our study were evaluate prevalence HPV-infection non-cancer lesions Mazandran, North Iran, identify lesions.Methods: A...
Thyroid transcription factor 2 (TTF2) also known as FOXE1 is one of the candidate genes thought to has been involved in thyroid development. Impairment this gene reported a few cases patients with congenital hypothyroidism resulting from dysgenesis (TD). In study we analyzed entire coding-region TTF2 50 infants who were referred Endocrine and Metabolism Research Center Isfahan University Medical Sciences TD by direct sequencing. The analysis revealed polymorphism ser 273 (TCC.TCT) 74%...