A5045042199- Sarcoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cutaneous Melanoma Detection and Management
- Cardiac tumors and thrombi
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Melanoma and MAPK Pathways
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Occupational and environmental lung diseases
- Cancer Cells and Metastasis
- Medical Imaging and Pathology Studies
- Colorectal Cancer Treatments and Studies
- Adrenal and Paraganglionic Tumors
- Musculoskeletal synovial abnormalities and treatments
- Bone Tumor Diagnosis and Treatments
- Polyomavirus and related diseases
- Oral and Maxillofacial Pathology
- Cancer and Skin Lesions
- CAR-T cell therapy research
- Colorectal and Anal Carcinomas
University of Padua
2015-2024
Azienda Ospedaliera di Padova
2017-2023
Virginia Commonwealth University
2014-2017
Massachusetts General Hospital
2014-2017
John Wiley & Sons (United States)
2016-2017
Hudson Institute
2016-2017
University Health Network
2017
Università Cattolica del Sacro Cuore
2017
Istituto Oncologico Veneto
2017
Mount Sinai Hospital
2014-2016
Epithelial-mesenchymal transition is a physiopathological process by which epithelial cells acquire mesenchymal shape and properties. Malignant mesothelioma histologically characterized the concomitant presence of epithelioid sarcomatoid features, latter being associated to worse prognosis, thus suggesting role epithelial-mesenchymal in this dual phenotype. We studied 109 malignant mesotheliomas (58 epithelioid, 26 sarcomatoid, 25 biphasic) immunohistochemistry qRT-PCR analysis, demonstrated...
Summary Background Among Western populations, the declining incidence of Helicobacter pylori infection coincides with a growing clinical impact autoimmune gastritis. Aims To describe histological phenotype gastritis , also to test prognostic OLGA staging in setting. Methods A single‐institutional series (spanning years 2003–2011) 562 consecutive patients (M:F ratio: 1:3.7; mean age = 57.6 ± 14.4 years) serologically confirmed underwent histology review and staging. Results was ascertained...
Identification of driver mutations in lung adenocarcinoma has led to development targeted agents that are already approved for clinical use or trials. Therefore, the number biomarkers will be needed assess is expected rapidly increase. This calls implementation methods probing mutational status multiple genes inoperable cases, which limited cytological bioptic material available. Cytology specimens from 38 adenocarcinomas were subjected simultaneous assessment 504 hotspots 22...
Ovarian serous carcinoma (OSC) is a fatal gynecologic malignancy usually presenting with bilateral localization and malignant peritoneal effusion. Programmed cell death 4 (PDCD4) tumor suppressor gene whose expression directly controlled by microRNA-21 (miR-21). Exosomes are small cell-derived vesicles that participate in intercellular communication, delivering their cargo of molecules to specific cells. involved several physiological pathological processes including oncogenesis,...
Claudin-18 (CLDN18) is a highly specific tight junction protein of the gastric mucosa. An isoform CLDN18, Claudin 18.2, has recently emerged as an innovative drug target for metastatic cancer. We investigated immunohistochemical profile p53, p16, E-cadherin, MSH2, MSH6, MLH1, PSM2, HER2, and PDL-1 in large series 523 primary carcinomas (GCs; n = 408) gastro-oesophageal (GECs; 115) 135 matched synchronous nodal metastases. The status HER2 EBER by means chromogenic situ hybridisation (CISH)...
Hepatocellular carcinoma (HCC) is a highly lethal cancer and the second leading cause of cancer-related deaths worldwide. As demonstrated in other solid neoplasms HCC, infiltrating CD8
The pathologic diagnosis of adrenocortical carcinoma (ACC) still needs to be improved, because the renowned Weiss Score (WS) system has a poor reproducibility some parameters and is difficult apply in borderline cases ACC variants. "reticulin algorithm" (RA) defines malignancy through an altered reticulin framework associated with 1 3 following parameter: necrosis, high mitotic rate, vascular invasion. This study aimed at validating interobserver stain evaluation unpublished series 245...
CK2 is a pivotal pro-survival protein kinase in multiple myeloma that may likely impinge on bortezomib-regulated cellular pathways. In the present study, we investigated expression and mantle cell lymphoma, two bortezomib-responsive B tumors, as well its involvement bortezomib-induced cytotoxicity signaling cascades potentially mediating bortezomib resistance. both correlated with of activated targets NF-κB STAT3 transcription factors. Bortezomib-induced proliferation arrest apoptosis were...
Laryngeal squamous cell carcinoma (LSCC) prognosis is definitely related to lymph node metastasis. Epithelial-mesenchymal transition (EMT) allows neoplastic cells gain the plasticity and motility required for tumour progression The aim of this study was investigate role EMT in LSCC.Immunohistochemical analysis E-cadherin, N-cadherin, Snail, Slug, ZEB1, ZEB2 performed 37 consecutive LSCC cases. Low E-cadherin levels high Slug correlated with both disease recurrence (P = 0.02 P =0.01,...
Tumor-infiltrating lymphocytes (TILs) evaluated in primary breast cancer (BC) convey prognostic information. Limited data the metastatic setting are available. Secondary lesions from 94 BC patients, 43 triple-negative (TN) and 51 HER2-positive, were for TILs expression of CD8, FOXP3, PD-L1 by immunohistochemistry. levels on metastasis generally low (median 5%) did not differ between TN HER2+ tumors. Younger patients showed significantly lower (p = 0.002). In higher lung metastases as...
To prospectively investigate the role of trans-thoracic fine needle aspiration cytology (FNA) and value rapid on-site evaluation (ROSE) in clinical management patients with pulmonary nodules/masses. Computed tomography (CT)-guided FNA is commonly employed for diagnosis lung lesions although its position diagnostic work-up still a matter debate.We reviewed 311 (211 males 100 females, mean age 69.5 years) admitted to University Padova from 2004 2008, correlating results available histological...
In pleural effusion cytology, the distinction of malignant mesothelioma (MM) from reactive mesothelial cells (RMCs) may be challenging, even with aid immunocytochemistry or fluorescence in situ hybridization. It has been demonstrated that several microRNAs (miRNAs) are useful for this purpose cell lines and histologic samples. current study, authors evaluated utility an miRNA-based classifier as a complement to cytology.Quantitative reverse transcriptase-polymerase chain reaction analysis 15...
Uveal melanoma (UM) represents the most common primary intra-ocular malignancy in adults. Up to 50% of patients develop distant metastases within 10 years from diagnosis, with liver as site. Upon metastatization, life expectancy strongly reduces and immune checkpoint inhibitors that prove effective cutaneous do not modify clinical outcome. To date, few studies have focused on deciphering immunomodulatory features metastatic UM microenvironment, there are no prognostic models for use. This...