A5018176262- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Oral and Maxillofacial Pathology
- Adrenal Hormones and Disorders
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Hepatitis B Virus Studies
- Cancer and Skin Lesions
- Medical Imaging and Pathology Studies
- African Sexualities and LGBTQ+ Issues
- Acute Myocardial Infarction Research
- Blood Coagulation and Thrombosis Mechanisms
- Meningioma and schwannoma management
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Occupational and environmental lung diseases
- Colorectal and Anal Carcinomas
Provincia Autonoma di Trento
2024
Azienda Ospedaliera Universitaria Integrata Verona
2024
AULSS 2 Marca Trevigiana
2021-2024
Ca' Foncello Hospital
2023
University of Padua
2016-2021
Hepatocellular carcinoma (HCC) is a highly lethal cancer and the second leading cause of cancer-related deaths worldwide. As demonstrated in other solid neoplasms HCC, infiltrating CD8
Abstract Context The oral glucose tolerance test (OGTT) is considered the most useful method for diagnosing active acromegaly and patient follow-up after neurosurgery. Despite its widespread use, only a few small studies have so far focused on patients’ clinical features associated with different GH responsiveness to OGTT. Objective We aimed investigate association between glucose-induced response endocrine profiles, manifestations, therapy in large cohort of patients acromegaly. Patients...
The use of adjuvant radiotherapy is controversial in patients with atypical meningiomas treated gross total resection (GTR). This study aimed to determine whether clinico-pathological features could be helpful predict the recurrence risk this group and identify high-risk ones who benefit from treatment. We collected 200 primary GTR but no 5 different centers. A score, formulated by assigning 1 point for presence 0 points absence parameters (male sex, parasagittal site, Simpson grade 3,...
Abstract Context DNA methylation has been identified among putative regulatory mechanisms for CYP11B2 expression in primary aldosteronism. Objective The objective of this work is to investigate and genes encoding steroidogenic enzymes benign adrenocortical tumors. Design Setting This cross-sectional study took place at university hospitals. Patients We collected fresh-frozen tissues from patients with adenomas (n = 48) (nonfunctioning n 9, autonomous cortisol secretion Cushing syndrome 17,...
Lung neuroendocrine neoplasms (lung NENs) are categorised by morphology, defining a classification sometimes unable to reflect ultimate clinical outcome. Subjectivity and poor reproducibility characterise diagnosis prognosis assessment of all NENs. Here, we propose machine learning framework for tumour based on quantitative, automated repeatable evaluation the spatial distribution cells immunohistochemically positive proliferation marker Ki-67, performed entire extent high-resolution whole...
Patients with solid tumors and mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H) are eligible for immunotherapy. Recently, different reports described patients poor performance status (PS), unrelated to comorbidities, which showed a rapid improvement of their clinical conditions under immunotherapy, evoked Lazarus response. Very few data on the efficacy safety immunotherapy in gynecological malignancies PS available. Based GARNET trial, Dostarlimab, monoclonal...
Sinonasal intestinal-type adenocarcinoma (ITAC) is a very rare, closely occupational-related tumor with strong histological similarities to colorectal cancer (CRC). In the latter, budding (TB) widely recognized as negative prognostic parameter. The aim of this study was evaluate role TB in ITAC and correlate it other established or emerging biomarkers disease, such p53 deficient DNA mismatch repair (MMR) system status/microsatellite instability (MSI). We retrospectively analyzed 32...
The aim of this histological study was to investigate DNA methylation and expression genes encoding steroidogenic enzymes in benign adrenocortical tumors. findings suggest that plays a regulatory role CYP11B2 may contribute aldosterone hypersecretion aldosterone-producing adenomas (APA).
DNA methylation has been recognized as a putative regulatory mechanism for CYP11B2 in primary hyperaldosteronism. We aimed to investigate the and expression of panel genes encoding several enzymes involved steroidogenesis adrenocortical benign tumors. collected total 60 tissues, including 9 non-functioning adrenal adenomas, adenomas associated with autonomous cortisol secretion, 17 Cushing’s syndrome, 13 Conn’s 12 tissues derived from gland adjacent adenomas. Non-functioning tumors secretion...