A5082717632- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Gene expression and cancer classification
- Circular RNAs in diseases
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Multiple Sclerosis Research Studies
- Sarcoma Diagnosis and Treatment
- Muscle Physiology and Disorders
- Molecular Biology Techniques and Applications
- Genomics and Phylogenetic Studies
- Peripheral Neuropathies and Disorders
- RNA Research and Splicing
- Gene Regulatory Network Analysis
- Machine Learning in Bioinformatics
- Single-cell and spatial transcriptomics
- Aquaculture Nutrition and Growth
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Tumors and Oncological Cases
- Metabolomics and Mass Spectrometry Studies
- Genomic variations and chromosomal abnormalities
University of Padua
2016-2025
University of Verona
2018
Imperial College London
2018
Medica (Italy)
2018
LMU Klinikum
2017
Ludwig-Maximilians-Universität München
2017
University of Insubria
2013-2014
Istituti di Ricovero e Cura a Carattere Scientifico
2014
University of Pavia
2014
Mario Negri Institute for Pharmacological Research
2013
Background: A significant inflammatory pathologic disorder in the cortex of patients with multiple sclerosis (MS) has been demonstrated by ex vivo studies.Objective: To determine frequency, time appearance, and clinical relevance intracortical lesions (ICLs) MS vivo.Design: Double inversion recovery sequence study.Setting: Multiple Sclerosis Centre Veneto Region.Patients: We enrolled 380 (116 clinically isolated syndrome [CIS], 163 relapsingremitting [RRMS], 101 secondary progressive [SPMS])...
Cortical inflammatory lesions have been correlated with disability and cortical atrophy in multiple sclerosis. The extent to which lesion load is associated longer-term physical cognitive different sclerosis phenotypes has not yet investigated. Thus, a 5-year prospective longitudinal study was carried on large group of patients Three hundred twelve consecutive suffering from (157 relapsing remitting, 35 paediatric, 45 benign, 44 primary progressive 31 secondary progressive) were enrolled...
Gray matter (GM) damage and meningeal inflammation have been associated with early disease onset a more aggressive course in multiple sclerosis (MS), but can these changes be identified the patient course?To identify possible biomarkers linking inflammation, GM damage, severity, gene protein expression were analyzed meninges cerebrospinal fluid (CSF) from 27 postmortem secondary progressive MS 14 control cases. Combined cytokine/chemokine CSF profiling 3T magnetic resonance imaging (MRI)...
Ovarian cancer is a leading cause of deaths among women. Effective targets to treat advanced epithelial ovarian (EOC) and biomarkers predict treatment response are still lacking because the complexity pathways involved in progression. Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression its functional target, Smad7. phosphorylated Smad2 enriched recurrent compared with matched-primary tumours their expression associated shorter time...
Abstract Background Butyrate has shown anti‐inflammatory and regenerative properties, providing symptomatic relief when orally supplemented in patients suffering from various colonic diseases. We investigated the effect of a colonic‐delivery formulation butyrate on fecal microbiota with inflammatory bowel diseases (IBDs). Methods In this double‐blind, placebo‐controlled, pilot study, 49 IBD (n = 19 Crohn's disease, CD n 30 ulcerative colitis, UC) were randomized to oral administration...
Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within lineage, HSCs have largest NADPH pools, are required proper and homeostasis. Bioinformatic analysis of transcriptome, biochemical assays, genetic inactivation FAO all indicate FAO-generated fuels cholesterol synthesis in HSCs. Interference with disturbs segregation toward...
Here we present a novel web tool for the statistical analysis of gene expression data in multiple tag sampling experiments. Differentially expressed genes are detected by using six different test statistics. Result tables, linked to GenBank, UniGene, or LocusLink database, can be browsed searched ways. Software is freely available at site: http://telethon.bio.unipd.it/bioinfo/IDEG6_form/ , together with additional information on methodologies.
Deep-sea life requires adaptation to high pressure, an extreme yet common condition given that oceans cover 70% of Earth's surface and have average depth 3800 meters. Survival at such depths specific but, compared with other conditions, pressure has received little attention. Recently, Photobacterium profundum strain SS9 been adopted as a model for piezophily. Here we report its genome sequence (6.4 megabase pairs) transcriptome analysis. The results provide first glimpse into the molecular...
Previous studies have reported that about 85% of human diversity at Short Tandem Repeat (STR) and Restriction Fragment Length Polymorphism (RFLP) autosomal loci is due to differences between individuals the same population, whereas among continental groups account for only 10% overall genetic variance. These findings conflict with popular notions distinct relatively homogeneous races, may also call into question apparent usefulness ethnic classification in, example, medical diagnostics....
Gene set analysis is moving towards considering pathway topology as a crucial feature. Pathway elements are complex entities such protein complexes, gene family members and chemical compounds. The conversion of to gene/protein networks (where nodes simple element like gene/protein) critical challenging task that enables topology-based analyses.Unfortunately, currently available R/Bioconductor packages provide only from single databases. They do not propagate signals through compounds...
In grapes, stilbene synthesis occurs in the skin, and it is induced by biotic abiotic stresses. To date, experimental evidence of a constitutive production resveratrols healthy grape scarce not conclusive. The aim present work was to investigate biosynthesis grapes both at biochemical molecular levels. By measuring concentration ripe berries 78 Vitis vinifera varieties for 3 years, we could identify significant differences among genotypes, providing first tentative varietal classification...
MAGIA (miRNA and genes integrated analysis) is a novel web tool for the integrative analysis of target predictions, miRNA gene expression data. divided into two parts: query section allows user to retrieve browse updated predictions computed with number different algorithms (PITA, miRanda Target Scan) Boolean combinations thereof. The comprises multistep procedure (i) direct integration through functional measures (parametric non-parametric correlation indexes, variational Bayesian model,...
Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine (MANECs) are heterogeneous neoplasms characterized by poor outcome. Microsatellite instability (MSI) has recently been found in colorectal NECs showing a better prognosis than expected. However, the frequency of MSI large series GEP-NEC/MANECs is still unknown. In this work, we investigated incidence their clinicopathologic molecular features. analysis immunohistochemistry for mismatch repair proteins...
<b>Background:</b> Although cognitive dysfunction affects a relevant portion of patients with multiple sclerosis (MS), its pathologic substrate has not been clarified and it does seem entirely explained by white matter changes. <b>Methods:</b> A total 100 consecutive relapsing remitting MS (RRMS) 42 normal controls (NC) were enrolled in the study. Cognitive performance was assessed Rao9s Brief Repeatable Battery Neuropsychological Tests (BRB). Regional cortical thickness (CTh) evaluated...
Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) malignancy, we analyzed miR expression in 77 primary breast carcinomas and identified 16 relapse-associated miRs that correlate with survival and/or distinguish tumor subtypes different datasets. Among them, miR-148b, down-regulated aggressive tumors, was found to be a major coordinator malignancy. In fact, it able oppose various steps progression when overexpressed cell lines by...
<b>Background:</b> In primary progressive multiple sclerosis (PPMS), a discrepancy exists between the modest brain white matter (WM) lesion burden and severity of neurologic disability. Double-inversion recovery (DIR) sequences have improved MRI sensitivity in detection cortical lesions (CLs) patients with relapsing-onset MS. <b>Objective:</b> This 2-year longitudinal study was designed to assess frequency, extent, rate formation CLs PPMS their relationship T2 volume (LV), gray (GM) atrophy,...
MAGIA(2) (http://gencomp.bio.unipd.it/magia2) is an update, extension and evolution of the MAGIA web tool. It dedicated to integrated analysis in silico target prediction, microRNA (miRNA) gene expression data for reconstruction post-transcriptional regulatory networks. miRNAs are fundamental regulators several key biological pathological processes. As act prevalently through degradation, their profiles expected be inversely correlated those genes. Low specificity prediction algorithms makes...
Gene set analysis using biological pathways has become a widely used statistical approach for gene expression analysis. A pathway can be represented through graph where genes and their interactions are, respectively, nodes edges of the graph. From point view only some portions are expected to altered; however, few methods topology have been proposed none them tries identify signal paths, within pathway, mostly involved in problem. Here, we present novel algorithm clipper, that fill this gap....
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS). Although cognitive impairment (CI) affects large proportion MS patients, only few data are available about its prognostic value associated with advanced magnetic resonance imaging (MRI) metrics.We aimed at investigating relationship between early CI and progression over 8-year follow-up in patients.We conducted retrospective longitudinal study involving 78 patients relapsing-remitting MS, who...
To investigate the relationship among cortical radiologic changes, number of early relapses (ERs), and long-term course multiple sclerosis (MS).In this cohort study, we assessed lesions (CLs) white matter (WM) thickness (Cth) at clinical onset after 7.9 mean years 219 patients with relapsing remitting (RR) MS 1 (Low-ER), 2 (Mid-ER), ≥3 (High-ER) ERs during first years. Kaplan-Meier Cox regression analyses investigated factors influencing risk secondary progressive (SP) MS.Fifty-nine (27%)...
Water temperature greatly influences the physiology and behaviour of teleost fish as other aquatic organisms. While are able to cope with seasonal variations, thermal excursions outside their normal range might exceed ability respond leading severe diseases death.Profound differences exist in tolerance across species living same geographical areas, promoting for investigating molecular mechanisms involved susceptibility resistance low high temperatures toward a better understanding...