A5027924873- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Hematopoietic Stem Cell Transplantation
- Psychometric Methodologies and Testing
- Acute Myeloid Leukemia Research
- Hepatitis C virus research
- Iron Metabolism and Disorders
- Hepatitis B Virus Studies
- Hemoglobinopathies and Related Disorders
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- Advanced Statistical Modeling Techniques
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune cells in cancer
- Magnesium in Health and Disease
- Potassium and Related Disorders
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Glaucoma and retinal disorders
- RNA regulation and disease
- Pharmacological Effects and Toxicity Studies
- Amyotrophic Lateral Sclerosis Research
Jikei University School of Medicine
2004-2025
Yokohama Municipal Citizen's Hospital
2024
Albert Einstein College of Medicine
2013-2024
Hidaka Hospital
2015-2024
Nagoya City University
1998-2024
Montefiore Health System
2023-2024
Tokyo Metropolitan Institute of Gerontology
2024
Montefiore Einstein Comprehensive Cancer Center
2023
Montefiore Medical Center
2019-2023
Osaka University
2008-2023
A single hematopoietic stem cell (HSC) is capable of reconstituting hematopoiesis and maintaining homeostasis by balancing self-renewal differentiation. The mechanisms HSC division balance, however, are not yet defined. Here we demonstrate, characterizing at the single-cell level a purified minimally heterogeneous murine Tie2+ population, that these top hierarchical HSCs preferentially undergo symmetric divisions. induction mitophagy, quality control process in mitochondria, plays an...
The bone marrow adjusts blood cell production to meet physiological demands in response insults. spatial organization of normal and stress responses are unknown owing the lack methods visualize most steps production. Here we develop strategies image multipotent haematopoiesis, erythropoiesis lymphopoiesis mice. We combine these with imaging myelopoiesis
Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within lineage, HSCs have largest NADPH pools, are required proper and homeostasis. Bioinformatic analysis of transcriptome, biochemical assays, genetic inactivation FAO all indicate FAO-generated fuels cholesterol synthesis in HSCs. Interference with disturbs segregation toward...
We compared quantity and structures of food-derived gelatin hydrolysates in human blood from three sources type I collagen a single blind crossover study. Five healthy male volunteers ingested fish scale, skin, or porcine skin after 12 h fasting. Amounts free form Hyp Hyp-containing peptide were measured over 24-h period. peptides comprised approximately 30% all detected Hyp. The total area under the concentration−time curve scale group was significantly higher than that group. Pro-Hyp major...
An interim analysis of an all-patient postmarketing surveillance programme in Japan to investigate the safety tocilizumab for treatment rheumatoid arthritis (RA) real world.This included 3881 patients. Patients received 8 mg/kg every 4 weeks, and were observed 28 weeks. Data on baseline characteristics adverse events (AE) collected.Total serious AE reported as 167 27 events/100 patient-years, respectively. The most frequent infections. Logistic regression identified following risk factors...
The Ten-eleven translocation (TET) enzymes regulate gene expression by promoting DNA demethylation and partnering with chromatin modifiers. TET2, a member of this family, is frequently mutated in hematological disorders. contributions TET2 hematopoiesis have been attributed to its demethylase activity, the significance nonenzymatic functions has remained undefined. To dissect catalytic non-catalytic requirements Tet2, we engineered catalytically inactive Tet2 mutant mice conducted...
We present safety and efficacy data from Japanese clinical studies on monotherapy with tocilizumab (TCZ), a humanized anti-interleukin 6 receptor monoclonal antibody, in which 601 patients moderate to severe rheumatoid arthritis, total of 2188 patient-years (pt-yr) exposure, were enrolled. The median treatment duration was 3.8 years. incidence adverse events (AEs), including abnormal laboratory test results, calculated as 465.1 per 100 pt-yr. most common serious (SAEs) infections (6.22...
Despite an increasing interest in vitamin D status, a reference range of the nutrient has not been fully established. This is partly due to paucity standardized measuring systems with high throughput. In addition, may vary by populations and change modernization lifestyles.This study aims calculate current concentration 25-hydroxyvitamin (25(OH)D) among healthy people living urban area Japan.A newly developed automated liquid chromatography coupled tandem mass spectrometry (LC-MS/MS) system...
AMPA receptor-mediated neurotoxicity is currently the most plausible hypothesis for etiology of amyotrophic lateral sclerosis (ALS). The mechanism initiating this type neuronal death believed to be exaggerated Ca2+-influx through receptors, which critically determined by presence or absence glutamate receptor subunit 2 (GluR2) in assembly. We have provided first quantitative measurements expression profile subunits mRNAs human single neurons means RT-PCR with a laser microdissector. Among...
Proline-hydroxyproline (Pro-Hyp) stimulated hyaluronic acid production in cultured synovium cells. It was detected guinea pig blood after oral ingestion of collagen hydrolysates. Oral administration hydrolysates increased the amount proteoglycans epiphyses. also reduced morphological changes associated with osteoarthritic cartilage destruction knee joint. The results suggest that have therapeutic potential for treatment osteoarthritis.
Summary Background Ultraviolet B ( UVB ) irradiation induces serious damage to the skin. Collagen hydrolysate and collagen‐derived peptides have effects on skin function in vivo vitro . However, few studies investigated changes epidermal barrier or dermal elasticity caused by Here, we loss of induced hairless mice fed collagen hydrolysate. Methods Mice were orally administered hydrolysate, a single dose (20 mJ/cm 2 repeated doses (10–30 , 3 times/week for 6 weeks), dorsal was exposed Skin...
Cardiovascular disease is the leading cause of morbidity and mortality in patients receiving hemodialysis. Systemic metabolic perturbation one hallmark abnormalities at high cardiovascular risk. We sought to determine relationship between circulating ketone body clinical outcomes with prevalent
The role of mitochondria in the fate determination hematopoietic stem and progenitor cells (HSPCs) is not solely limited to switch from glycolysis oxidative phosphorylation, but also involves alterations mitochondrial features properties, including membrane potential (ΔΨmt). HSPCs have a high ΔΨmt even when rates respiration phosphorylation are low, we previously shown that minimum proton flow through ATP synthesis (or complex V) enables HSPCs. Here show sustain unique equilibrium between...
Vascular calcification is associated with a poor prognosis in dialysis patients. It can be assessed computed tomography but simple inoffice techniques may provide useful information. We compared the results obtained noninvasive technique those using multidetector for aortic arch volume (AoACV) chronic hemodialysis (HD) The enrolled study subjects were 63 (32 men and 31 women) maintenance HD Calcification of was semiquantitatively estimated AoAC score (AoACS) on plain chest radiology. AoACV...