A5072514662- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Blood Pressure and Hypertension Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cancer, Lipids, and Metabolism
- Parathyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Renin-Angiotensin System Studies
- Electrolyte and hormonal disorders
- Renal and Vascular Pathologies
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Health and Disease Prevention
- Receptor Mechanisms and Signaling
- Ion Transport and Channel Regulation
- Stress Responses and Cortisol
- Vitamin D Research Studies
- Apelin-related biomedical research
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Sodium Intake and Health
University of Padua
2014-2024
Sapienza University of Rome
2021
Istituto Neurologico Mediterraneo
2021
University of Trieste
2014-2016
University of Turin
2001-2016
Istituto Oncologico Veneto
2016
Federico II University Hospital
2016
Inserm
2012-2015
Centre de Recherche des Cordeliers
2015
Istituti di Ricovero e Cura a Carattere Scientifico
2015
Several factors have been proposed to explain the high death rate of coronavirus disease 2019 (COVID-19) outbreak, including hypertension and hypertension-related treatment with Renin Angiotensin System inhibitors. Also, age multimorbidity might be confounders. No sufficient data are available demonstrate their independent role. We designed a cross-sectional, observational, multicenter, nationwide survey in Italy verify whether renin-angiotensin system inhibitors related COVID-19 severe...
Patients with hypertension have a high prevalence of concurrent metabolic abnormalities, including obesity, dyslipidemia, and hyperglycemia. Clustering these cardiovascular risk factors, defined as syndrome, causes more pronounced target organ damage. Aldosterone excess has been found to be associated glucose disorders may contribute damage.The aim our study was assess the characteristics syndrome in group patients due primary aldosteronism compared essential hypertension.The National...
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5 , ATP1A1 ATP2B3 and CACNA1D have been described aldosterone-producing adenomas (APAs). Our aim was to investigate prevalence somatic these genes unselected patients with APA (n=474), collected through European Network for Study Adrenal Tumors. Correlations clinical biochemical parameters were first analyzed a subset 199 from single center then replicated 2 additional centers. heterozygous...
Primary aldosteronism is the most common form of secondary hypertension. Mutations in KCNJ5 gene have been described recently aldosterone-producing adenomas (APAs). The aim this study was to investigate prevalence mutations unselected patients with primary and their clinical, biological molecular correlates. sequencing performed on somatic (APA, n=380) peripheral n=344; bilateral adrenal hyperplasia, n=174) DNA aldosteronism, collected through European Network for Study Adrenal Tumors....
: Autonomous aldosterone overproduction represents the underlying condition of 5-10% patients with arterial hypertension and carries a significant burden mortality morbidity. The diagnostic algorithm for primary aldosteronism is sequentially based on hormonal tests (screening confirmation tests), followed by lateralization studies (adrenal CT scanning adrenal venous sampling) to distinguish between unilateral bilateral disease. Despite recommendations Endocrine Society guideline, largely...
The natural course of adrenal incidentalomas and the risk that such lesions evolve toward hormonal hypersecretion or malignancy are still under evaluation. Of 246 consecutive patients with incidentaloma studied at our institution in last 15 yr, 91 underwent surgery. remaining patients, a group 75 (52 females 23 males; median age, 56 yr; range, 19–77 yr) incidentally discovered asymptomatic masses (60 unilateral bilateral; diameter, 2.5 cm; 1.0–5.6) was enrolled an endocrine morphological...
Objectives : Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and frequently associated with obesity metabolic syndrome. The recently discovered hormone adiponectin produced by adipose tissue, low plasma considered key factor in the development insulin resistance underlying Animal studies suggest that may protect against non-alcoholic steatohepatitis, but direct evidence humans lacking. We therefore conducted this study to assess relationship between...
Although transphenoidal pituitary microsurgery has become the treatment of choice in Cushing's disease, other procedures, such as bilateral adrenalectomy and irradiation, are currently use its management. Indeed, no proven to be fully satisfactory for this condition. The rates cure recurrence after surgery or irradiation incidence Nelson's syndrome still open issues. A population 162 patients with pituitary-dependent disease was studied at 1 institution had a follow-up least 2 yr (median, 7...
Primary aldosteronism (PA) is the most frequent form of secondary hypertension, accounting for up to 5-10% all hypertensive patients, and diagnosis PA can present an important challenge clinician. After a positive screening test, confirmed by suppression often iv saline load test (SLT) or fludrocortisone (FST). The FST considered many be reliable but more complex expensive.Our objective was compare specificity SLT with PA.The study included 100 patients referred hypertension units suspected...
A hypercoagulable state and an increased incidence of thromboembolic complications are reported in Cushing's syndrome. The is related to increase plasma clotting factors, especially Factor VIII von Willebrand factor complex, impairment fibrinolytic capacity. Retrospective analysis postoperative events a large group patients with syndrome, including 75 (group 1) evaluated the period from 1972–1981 not receiving anticoagulants, 232 2), 1982–2000. Patients 1 underwent routine hemostatic...
Aldosterone-producing adenomas (APAs) cause a sporadic form of primary aldosteronism and somatic mutations in the KCNJ5 gene, which encodes G-protein–activated inward rectifier K + channel 4, GIRK4, account for ≈40% APAs. Additional APA were identified recently 2 other genes, ATP1A1 ATP2B3 , encoding Na /K -ATPase 1 Ca 2+ 3, respectively, at combined prevalence 6.8%. We have screened 112 APAs known hotspots genetic alterations associated with aldosteronism. Somatic present 6.3%, 0.9%, 39.3%...
Unilateral primary aldosteronism is the most common surgically correctable form of endocrine hypertension and usually differentiated from bilateral forms by adrenal venous sampling (AVS) or computed tomography (CT). Our objective was to compare clinical biochemical postsurgical outcomes patients with unilateral diagnosed CT AVS identify predictors surgical outcomes. Patient data were obtained 18 internationally distributed centers retrospectively analyzed for adrenalectomy management based...
Metabolic syndrome is a major risk factor for the development of diabetes mellitus and cardiovascular diseases. Pharmacological antagonism mineralocorticoid receptor (MR), ligand-activated transcription factor, limits metabolic in preclinical models, but mechanistic studies are lacking to delineate role MR activation adipose tissue. In this study, we report that expression increased visceral tissue mouse model obese patients. vivo conditional upregulation adipocytes led weight fat mass,...
Hormonal and morphological data were investigated in 202 consecutive patients with adrenal incidentalomas (171 unilateral 31 bilateral) an attempt to assess subclinical hyperfunction or malignancy. In addition the classical evaluation, scintiscan was carried out a large number of these patients. incidentalomas, 83% showed normal hormonal function, whereas 17% had biochemical signs overactivity (hyperaldosteronism 3, hypercortisolism 17, medullary 9). [75Se]Methylnorcholesterol scintigraphy...
OBJECTIVE: The natural course of adrenal incidentalomas, especially those with subclinical autonomous glucocorticoid production, i.e. Cushing's syndrome, and the risk that such conditions will evolve towards overt syndrome are unknown. DESIGN: Longitudinal follow-up evaluation a series 284 consecutive patients incidentaloma. METHODS AND RESULTS: Out incidentaloma studied at our Institution in last 15 years, 98 (23 hypercortisolism) underwent surgery. Of 130 non-operated least 1 year, eight...
Major depression is a common, life-threatening complication of Cushing’s syndrome, with no significant differences between pituitary-dependent and -independent forms. Little known about the clinical correlates depression; in particular, whether patients disease major show some features that are distinctive compared to those who not depressed. The occurrence according DSM-IV criteria was ascertained 162 Cushing disease. occurred 88 (54%). It significantly associated older age, female sex,...