A5090242403- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Blood Pressure and Hypertension Studies
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Receptor Mechanisms and Signaling
- Quantum Chromodynamics and Particle Interactions
- Ion Transport and Channel Regulation
- Sodium Intake and Health
- Nitric Oxide and Endothelin Effects
- Electrolyte and hormonal disorders
- Adrenal Hormones and Disorders
- Renal function and acid-base balance
- Adrenal and Paraganglionic Tumors
- Apelin-related biomedical research
- Cardiac, Anesthesia and Surgical Outcomes
- Neuropeptides and Animal Physiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dark Matter and Cosmic Phenomena
- Muon and positron interactions and applications
- Heart Rate Variability and Autonomic Control
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neutrino Physics Research
- Protein Hydrolysis and Bioactive Peptides
- Birth, Development, and Health
Boston University
2002-2024
University of Virginia Health System
2014-2023
University of Virginia
2013-2023
Flinders Medical Centre
2023
GTx (United States)
2021-2022
University of Southern Denmark
2013-2022
University of Cape Town
2022
Charité - Universitätsmedizin Berlin
2022
Humboldt-Universität zu Berlin
2022
Freie Universität Berlin
2022
To develop clinical practice guidelines for the management of patients with primary aldosteronism.The Task Force included a chair, selected by Clinical Guidelines Subcommittee Endocrine Society, six additional experts, methodologist, and medical writer. The guideline was cosponsored American Heart Association, Association Surgeons, European Society Endocrinology, Hypertension, International Japan Japanese Hypertension. received no corporate funding or remuneration.We searched systematic...
Resistant hypertension is a common clinical problem faced by both primary care clinicians and specialists. While the exact prevalence of resistant unknown, trials suggest that it not rare, involving perhaps 20% to 30% study participants. As older age obesity are 2 strongest risk factors for uncontrolled hypertension, incidence will likely increase as population becomes more elderly heavier. The prognosis but cardiovascular undoubtedly increased patients often have history long-standing,...
Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism.
Resistant hypertension is a common clinical problem faced by both primary care clinicians and specialists. While the exact prevalence of resistant unknown, trials suggest that it not rare, involving perhaps 20% to 30% study participants. As older age obesity are 2 strongest risk factors for uncontrolled hypertension, incidence will likely increase as population becomes more elderly heavier. The prognosis but cardiovascular undoubtedly increased patients often have history long-standing,...
Background: The 2017 American College of Cardiology/American Heart Association (ACC/AHA) Guideline for the Prevention, Detection, Evaluation and Management High Blood Pressure in Adults provides recommendations definition hypertension, systolic diastolic blood pressure (BP) thresholds initiation antihypertensive medication, BP target goals. Objectives: This study sought to determine prevalence implications above treatment goal among US adults using criteria from ACC/AHA guideline Seventh...
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a patient despite the concurrent use of 3 antihypertensive drug classes, commonly including long-acting calcium channel blocker, blocker renin-angiotensin system (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker), and diuretic. The drugs should be administered at maximum maximally tolerated daily doses. RH also includes patients whose BP achieves target values on ≥4 medications....
Since publication of the 1980 Report Joint National Committee on Detection, Evaluation, and Treatment High Blood Pressure,<sup>1</sup>several events have occurred that affect successful management hypertension: major clinical trial results, introduction new antihypertensive agents, evidence concerning effectiveness nonpharmacologic treatment, further analysis epidemiologic data-base relating BPs with risk premature morbidity mortality. These led director Heart, Lung, Institute (NHLBI), as...
Patchy subcortical foci of increased signal intensity are frequently identified on magnetic resonance imaging (MRI) in the elderly. The incidence and clinical correlates these lesions remain unknown. In this report, 240 consecutive MRI scans performed over a 6-month period were reviewed (excluding patients with recent brain trauma or known demyelinating disease). Subcortical incidental (ILs) identified, which could not be accounted for by patient's current diagnosis, neurological status, CT...
A precise measurement of the anomalous g value, a(mu) = (g-2)/2, for positive muon has been made at Brookhaven Alternating Gradient Synchrotron. The result a(mu+) 11 659 202(14) (6) x 10(-10) (1.3 ppm) is in good agreement with previous measurements and an error one third that combined data. current theoretical value from standard model a(mu)(SM) 159.6(6.7) (0.57 a(mu)(exp) - 43(16) which world average experimental value.
The angiotensin AT2 receptor modulates renal production of cyclic guanosine 3',5'-monophosphate (cGMP; J. Clin. Invest. 1996. 97:1978-1982). In the present study, we hypothesized that II (Ang II) acts at to stimulate nitric oxide leading previously observed increase in cGMP. Using a microdialysis technique, monitored changes interstitial fluid (RIF) cGMP response intravenous infusion antagonist PD 123319 (PD), AT1 Losartan, synthase (NOS) inhibitor nitro--arginine-methyl-ester (-NAME),...
Description: In November 2017, the American College of Cardiology (ACC) and Heart Association (AHA) released a clinical practice guideline for prevention, detection, evaluation, treatment high blood pressure (BP) in adults. This article summarizes major recommendations. Methods: 2014, ACC AHA appointed multidisciplinary committee to update previous reports Joint National Committee on Prevention, Detection, Evaluation, Treatment High Blood Pressure. The reviewed literature commissioned...
Primary aldosteronism is a nonsuppressible renin-independent aldosterone production that causes hypertension and cardiovascular disease.To characterize the prevalence of production, as well biochemically overt primary aldosteronism, in relation to blood pressure.Cross-sectional study.4 U.S. academic medical centers.Participants with normotension (n = 289), stage 1 115), 2 203), resistant 408).Participants completed an oral sodium suppression test, regardless or renin levels, confirmatory...