A5017829907- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pituitary Gland Disorders and Treatments
- Neuropeptides and Animal Physiology
- Blood Pressure and Hypertension Studies
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Estrogen and related hormone effects
- Ion Transport and Channel Regulation
- Renin-Angiotensin System Studies
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Renal and Vascular Pathologies
- Neuroendocrine regulation and behavior
- Hormonal and reproductive studies
- Pharmacogenetics and Drug Metabolism
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Neuroendocrine Tumor Research Advances
- Cardiac Imaging and Diagnostics
- Drug Transport and Resistance Mechanisms
- Regulation of Appetite and Obesity
Tohoku University
2016-2025
Tohoku University Hospital
2015-2024
Hypertension Institute
2023
University of Mississippi Medical Center
2014-2017
G.V. (Sonny) Montgomery VA Medical Center
2014-2017
Tohoku Medical and Pharmaceutical University
2015-2016
The University of Queensland
2015-2016
Universitätsklinikum Würzburg
2015-2016
University of Verona
2015-2016
Ludwig-Maximilians-Universität München
2016
Adrenal venous sampling is recommended by current guidelines to identify surgically curable causes of hyperaldosteronism but remains markedly underused. Key factors contributing the poor use adrenal include prevailing perceptions that it a technically challenging procedure, difficult interpret, and can be complicated vein rupture. In addition, lack uniformly accepted standards for performance contributes its limited use. Hence, an international panel experts working at major referral centers...
The Japan Endocrine Society (JES) attempted to develop guidelines for the diagnosis and treatment of primary aldosteronism (PA). Task Force Committee (TFC) was composed a chair, selected by JES, additional experts. Systematic reviews available evidence Japanese patients were used recommend key prevention. We have evaluated methods screening, confirmatory tests imaging, plus adrenal vein sampling (AVS). Consensus guided systematic review discussion during each annual meeting its related...
In patients who seek surgical cure of primary aldosteronism (PA), The Endocrine Society Guidelines recommend the use adrenal vein sampling (AVS), which is invasive, technically challenging, difficult to interpret, and commonly held be risky. aim this study was determine complication rate AVS ways in it performed interpreted at major referral centers. Adrenal Vein Sampling International Study an observational, retrospective, multicenter conducted centers for endocrine hypertension worldwide....
A broad analysis of adrenal gland-derived 19-carbon (C19) steroids has not been reported. This is the first study that uses liquid chromatography-tandem mass spectrometry to quantify 9 C19 (androgens and their precursors), estrone, estradiol in vein (AV) women, before after ACTH stimulation.The objective this was define androgen metabolome women infusion.This a retrospective study.Seven aged 50.4 ± 5.4 years, with suspected diagnosis an aldosterone-producing adenoma were included study.AV...
Abstract Objective Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA). Context Unilateral PA is most common surgically treated form hypertension. Morphologic examination combined with CYP11B2 (aldosterone synthase) immunostaining reveals diverse lesions resected adrenals. Patients Methods Surgically removed adrenals (n = 37) from 90 patients operated 2015 to 2018 Munich, Germany, were selected represent broad...
Primary aldosteronism affects ≈5% to 10% of hypertensive patients and has unilateral bilateral forms. Most primary is caused by computed tomography-detectable aldosterone-producing adenomas, which express CYP11B2 (aldosterone synthase) frequently harbor somatic mutations in aldosterone-regulating genes. The cause the most common form aldosteronism, idiopathic hyperaldosteronism (IHA), believed be diffuse hyperplasia cells within adrenal cortex. Herein, a multi-institution cohort 15 IHA...
Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and mortality rates than essential hypertension. The Japan Endocrine Society (JES) has developed an updated guideline for PA, based on the evidence, especially from Japan. We should preferentially screen hypertensive patients a high prevalence of PA aldosterone to renin ratio ≥200 plasma concentrations (PAC) ≥60 pg/mL as cut-off positive results. While we confirm excess secretion by one confirmatory test, could...
Digoxin, which is one of the most commonly prescribed drugs for treatment heart failure, mainly eliminated from circulation by kidney. P-glycoprotein well characterized as a digoxin pump at apical membrane nephron. However, little known about transport mechanism basolateral membrane. We have isolated an organic anion transporter (OATP4C1) human Human OATP4C1 first member transporting polypeptide (OATP) family expressed in The cDNA encodes 724 aa with 12 transmembrane domains. genomic...
ABSTRACT. Aldosterone (Aldo) accelerates hypertension, proteinuria, and glomerulosclerosis in animal models of malignant hypertension or chronic renal failure. Aldo may exert these deleterious effects by elevating vascular resistance glomerular capillary pressure. To test this possibility, directly examined were the action on afferent (Af) efferent (Ef) arterioles (Arts). Examined effect added to both bath lumen intraluminal diameter (measured at most responsive point) rabbits. caused...
Adrenocortical carcinoma (ACC) is a rare, highly malignant tumor. The aim of the present study to evaluate prognostic relevance proliferation marker Ki67/MIB1 by immunohistochemistry in 17 cases who underwent resections primary tumors and diagnosed have ACC at Tohoku University Hospital based on criteria Weiss during period from 1976 2005. follow-up periods ranged 221 days 10659 (about 29 years) with median 1895 days. age diagnosis was 46 years old, mean size 7.1 cm minimal 3.5 cm. labeling...
Approximately half of patients with primary aldosteronism (PA) have clinically evident disease according to clinical (hypertension) and/or laboratory (aldosterone and renin levels) findings but do not nodules detectable in routine cross-sectional imaging. However, the detailed histopathologic, steroidogenic, pathobiological features image–negative PA are controversial. To examine histopathology, steroidogenic enzyme expression, aldosterone-driver gene somatic mutation status...
We sought to measure the clinical benefits of adrenal venous sampling (AVS), a test recommended by guidelines for primary aldosteronism (PA) patients seeking surgical cure, in large registry PA submitted AVS. Data 1625 consecutive AVS 19 tertiary referral centers located Asia, Australia, Europe, and North America were collected multicenter international registry. The end points rate bilateral success, ascertained lateralization PA, adrenalectomy, cured arterial hypertension among AVS-guided...
Adrenal venous sampling is currently the only reliable method to distinguish unilateral from bilateral diseases in primary aldosteronism. In this study, we attempted determine whether peripheral plasma levels of 18-oxocortisol (18oxoF) and 18-hydroxycortisol could contribute clinical differentiation between aldosteronoma hyperaldosteronism 234 patients with aldosteronism, including computed tomography (CT)–detectable (n=113) (n=121), all whom underwent CT adrenal sampling. All aldosteronomas...
Unilateral primary aldosteronism is the most common surgically correctable form of endocrine hypertension and usually differentiated from bilateral forms by adrenal venous sampling (AVS) or computed tomography (CT). Our objective was to compare clinical biochemical postsurgical outcomes patients with unilateral diagnosed CT AVS identify predictors surgical outcomes. Patient data were obtained 18 internationally distributed centers retrospectively analyzed for adrenalectomy management based...
Aldosterone synthase (CYP11B2) immunohistochemistry and next-generation sequencing (NGS) have revealed the frequent presence of aldosterone-producing cell clusters (APCCs) harboring somatic mutations in aldosterone-regulating genes adrenals from Americans without defined hypertension status. Determine frequency mutation status APCCs a Japanese nonhypertensive cohort. Adrenals 837 consecutive autopsies at institution, Tohoku University Hospital, were screened to select 107 unilateral adrenal...
In primary aldosteronism (PA), glomerular hyperfiltration due to excessive aldosterone is considered underestimate actual renal damage.Our objectives were determine the prevalence of chronic kidney disease (CKD) in PA and identify predictors decreasing estimated filtration rate (eGFR) after treatment.This was a 12-month prospective study patients with treated at Tohoku University Hospital.All according results adrenal venous sampling; 102 aldosterone-producing adenoma underwent...
: Primary aldosteronism is a frequent cause of secondary hypertension requiring specific pharmacological treatment with mineralocorticoid receptor antagonist or unilateral adrenalectomy. These treatments have shown to reduce the excess cardiovascular risk characteristically associated this disease. In part I consensus, we discussed procedures for diagnosis primary aldosteronism. present II, address strategies differential subtypes and therapy. We also discuss evaluation outcomes provide...
Objective: To develop a prediction model for clinical outcomes after unilateral adrenalectomy primary aldosteronism. Summary Background Data: Unilateral aldosteronism is the most common surgically curable form of endocrine hypertension. Surgical resection dominant overactive adrenal in results complete success with resolution hypertension without antihypertensive medication less than half patients wide between-center variability. Methods: A linear discriminant analysis was built using data...
Adrenal venous sampling (AVS) is the key test for subtyping primary aldosteronism (PA), but its interpretation varies widely across referral centers and this can adversely affect management of PA patients.To investigate in a real-life study rate bilateral success identification unilateral their impact on blood pressure outcomes subtyped by AVS.In retrospective analysis largest international registry individual AVS data (AVIS-2 study), we investigated how different cut-off values selectivity...
Abstract Aldosterone-producing adenomas (APAs) are the commonest curable cause of hypertension. Most have gain-of-function somatic mutations ion channels or transporters. Herein we report discovery, replication and phenotype in neuronal cell adhesion gene CADM1 . Independent whole exome sequencing 40 81 APAs found intramembranous p.Val380Asp p.Gly379Asp variants two patients whose hypertension periodic primary aldosteronism were cured by adrenalectomy. Replication identified more with each...