A5032398786- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Pituitary Gland Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ophthalmology and Eye Disorders
- Diabetes Management and Research
- Blood Pressure and Hypertension Studies
- Ultrasound Imaging and Elastography
- Growth Hormone and Insulin-like Growth Factors
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Glaucoma and retinal disorders
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Cerebral Venous Sinus Thrombosis
- Adipokines, Inflammation, and Metabolic Diseases
Tottori University
2016-2025
Tottori University Hospital
2018-2021
Faculty of Media
2020
Saku Central Hospital
2019
Kyoto Medical Center
2005-2018
Kanazawa University
2018
Kyoto University
2018
Keio University
2018
Jichi Medical University
2008
Kurashiki Central Hospital
2007
There have been several clinical studies examining the factors associated with cardiovascular disease (CVD) in patients primary aldosteronism (PA); however, their results left it unclear whether CVD is affected by plasma aldosterone concentration or hypokalemia. We assessed PA database established multicenter JPAS (Japan Primary Aldosteronism Study) and compared prevalence of among that age-, sex-, blood pressure-matched essential hypertension participants a general population cohort. also...
Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and mortality rates than essential hypertension. The Japan Endocrine Society (JES) has developed an updated guideline for PA, based on the evidence, especially from Japan. We should preferentially screen hypertensive patients a high prevalence of PA aldosterone to renin ratio ≥200 plasma concentrations (PAC) ≥60 pg/mL as cut-off positive results. While we confirm excess secretion by one confirmatory test, could...
OBJECTIVE To investigate the prevalence and causes of diabetes in patients with primary aldosteronism (PA) a multi-institutional cohort study Japan. RESEARCH DESIGN AND METHODS The was determined 2,210 PA (diagnosed or glycated hemoglobin [HbA1c] ≥6.5% [≥48 mmol/mol]; NGSP) compared that Japanese general population according to age sex. In 1,386 clear laterality (unilateral bilateral), effects plasma aldosterone concentration (PAC), hypokalemia (<3.5 mEq/L), suspected subclinical...
We developed a simple and new insulin resistance index derived from glucose clamp meal tolerance test (MTT) in Japanese patients with type 2 diabetes mellitus. Fifteen [mean age: 53 years, fasting plasma (FPG) 7.7 mmol/L, HbA1c 7.1% (54 mmol/mol), body mass 26.8 kg/m2] underwent MTT clamp. Participants were given (450 kcal). Plasma measured at 0 (fasting), 30, 60, 120, 180 min. Serum C-peptide immunoreactivity (CPR) was (fasting; F-CPR) 120 Homeostasis model assessment of (HOMA-IR)...
Type 2 diabetes mellitus (T2DM) is caused by insulin resistance and β cell dysfunction. In recent studies reported that several markers associated with sensitivity in skeletal muscle, Adiponectin other parameters, such as fatty acid-binding protein (FABP4), have been to regulate resistance, but it remains unclear which factor mostly affects T2DM. this cross-sectional study, we evaluated the relationships between kinds of biomarkers secretion T2DM healthy controls. We recruited 30...
Background Screening for undiagnosed type 2 diabetes mellitus is recommended Asian Americans with a body mass index ≥23. However, the optimal cut-off score predicting risk of in Japanese people not well known. The aim this study was to determine best insulin resistance and population. Methods This had two parts, clinical investigation retrospective observational investigation. In part study, 58 participants (26 32 non-diabetics) underwent hyperinsulinemic-euglycemic clamp from which their...
Primary aldosteronism causes renal structural damage after glomerular hyperfiltration, and primary aldosteronism-specific treatment leads to an acute fall in estimated filtration rate (eGFR). We investigated whether this change affected the long-term eGFR slope a retrospective cohort from multicenter Japan Aldosteronism Study. allocated patients with adrenalectomy (n=202) MR (mineralocorticoid receptor) antagonist (n=303) groups based on their history analyzed association between initial...
The aims of this study were to evaluate the utility shear wave elastography (SWE) using acoustic radiation force impulse (ARFI) for diagnosing chronic autoimmune thyroiditis (CAT) and verify effect fibrotic thyroid tissue on velocity (SWV). subjects 229 patients with 253 normal lobes (controls) 150 CAT lobes. SWV (2.47 ± 0.57 m/s) was significantly higher than that controls (1.59 0.41 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Several clinical studies have reported that renal impairments are sometimes observed in patients with primary aldosteronism (PA). We analyzed the prevalence of PA and identified parameters increase risk for them.This is a retrospective cross-sectional study. assessed database established by multicenter Japan study (JPAS). Data were also collected from essential hypertension (EHT).We compared prevalences proteinuria lowered estimated glomerular filtration rate (eGFR) between age, sex, blood...
Galectin-3 is a family of soluble beta-galactoside-binding lectins that play many important regulatory roles in inflammation. Galectin-3-deficient mice have been shown to exhibit excess adiposity, hyperglycemia, insulin resistance and systemic We investigated the association between serum galectin-3 patients with type 2 diabetes using glucose clamp method.This was cross-sectional study. Twenty (mean fasting plasma 7.6 mmol/L, HbA1c 7.2%, BMI 28.1 kg/m(2)) underwent meal tolerance test test....
The aim of this study was to investigate the impact adrenal venous sampling (AVS) lateralization cutoffs on surgical outcomes.Cosyntropin-stimulated AVS used guide management 377 patients with primary aldosteronism (PA) who were evaluated 6 months after surgery.The proportion that achieved clinical benefit and complete biochemical success based aldosterone index (LI) determined.Clinical in 29 47 an LI between 2 4, 66 101 4 10, 158 203 > 10 (P < 0.01 for trend). Complete 27 42 60 76 127 155 =...
Primary aldosteronism (PA) is the most frequent cause of secondary hypertension. Adrenal vein sampling (AVS) an established method for finding patients with unilateral subtype PA, which adrenalectomy applicable treatment. In this study, we analyzed a large database PA who underwent adrenal sampling, to investigate sex differences in impact age at diagnosis on and PA. 2122 patients, women were younger than men same bilateral subtype. Younger older associated men, respectively. After...
In Japan, the standard method for measuring plasma aldosterone concentration (PAC) primary aldosteronism (PA) diagnosis was changed from radioimmunoassay (RIA) to a novel chemiluminescent enzyme immunoassay (CLEIA). The purpose of this study is simulate possible impact change on PA diagnosis. This retrospective assessed 2,289 patients. PACs measured by conventional RIA were transformed estimated (CLEIA) as follows: (pg/mL) = 1.174 × CLEIA + 42.3. We applied PAC cut-off aldosterone-to-renin...
Adrenal Cushing syndrome (CS) has been rarely studied in recent years Japan. This study aimed to investigate clinical characteristics and their changes over time patients with adrenal CS. We analyzed 101 CS caused by adenoma, dividing them into two groups based on diagnosis period: December 2011–November 2016 (later group, n = 50) August 2005–November 2011 (earlier 51). Differences between the comparisons previous reports were assessed. Patients subclinical excluded. incidentalomas most...
Shear wave elastography (SWE) using acoustic radiation force impulse (ARFI) is a novel ultrasonography technique. The aim of this study was to investigate the clinical usefulness quantitative SWE for differentiating thyroid nodules. For phantom study, we measured shear velocities (SWVs) four spheres 2- and 1-cm diameters with varying hardness. SWVs normal glands nodules, that were classified as benign or malignant according either cytological pathological findings, measured. each patient...
<i>Objective</i>. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects animal and cell culture models may promote resistance nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs human serum. Here, we use this to investigate relationship between secretion patients with T2DM. <i>Methods</i>. Our study involved 15...
In primary aldosteronism (PA), renal impairment has been identified as an important comorbidity. Excess cortisol production also may lead to damage; thus, concomitant mild autonomous secretion (MACS) predispose PA patients disorders. However, there is limited evidence support this claim. Therefore, study aimed determine whether the concurrence of MACS and increases risk complications.This a retrospective cross-sectional study.A total 1310 with were stratified into two groups according 1 mg...
Abstract This study aimed to develop a machine-learning algorithm diagnose aldosterone-producing adenoma (APA) for predicting APA probabilities. A retrospective cross-sectional analysis of the Japan Rare/Intractable Adrenal Diseases Study dataset was performed using nationwide PA registry in comprised 41 centers. Patients treated between January 2006 and December 2019 were included. Forty-six features at screening 13 confirmatory test used model development calculate probability. Seven...
In Graves' ophthalmopathy (GO), fibrosis in extraocular muscles (EOMs) may be related to intravenous glucocorticoid (ivGC)-resistant diplopia. Signal intensity (SI) of magnetic resonance imaging (MRI) T1 mapping can quantify properties EOM components, including fibrosis. We investigated features GO patients with diplopia using SI and the predictive value response ivGCs.We performed a cross-sectional study that included 13 active patients, 34 inactive history diplopia, 20 disappearance, 14...
Introduction Hepatic insulin clearance (HIC) is an important pathophysiology of type 2 diabetes. HIC was reported to decrease in patients with diabetes and metabolic syndrome. However, hyperglycemia suggested enhance HIC, it not known whether poorly controlled increases We investigated increased diabetes, associated resistance incretins. Research design methods performed a meal tolerance test the hyperinsulinemic–euglycemic clamp 21 calculated postprandial C-peptide area under curve...
Left ventricular hypertrophy (LVH) is often seen in patients with primary aldosteronism (PA), and the prevalence of LVH reportedly higher among PA than essential hypertension. However, correlation between aldosterone levels undefined, how affects remains unclear. We, therefore, retrospectively assessed a large database established by multicenter JPAS (Japan Primary Aldosteronism Study) to reveal factors associated without suspected autonomous cortisol secretion. In 1186 studied, basal plasma...
Graves' ophthalmopathy (GO) is a common manifestation of disease (GD); however, its pathogenesis not well understood. Recently, the dysregulation regulatory T cells (Tregs) has been thought to be closely associated with and clinical symptoms autoimmune disease. We therefore evaluated whether cell subsets, including Tregs, are GO symptoms. In this observational study we 35 GD patients overt (GOs) 28 without (non-GOs). Fifteen healthy euthyroid served as controls (HCs). Peripheral blood...