A5050677639- Hormonal Regulation and Hypertension
- Dialysis and Renal Disease Management
- Adrenal and Paraganglionic Tumors
- Acute Kidney Injury Research
- Adrenal Hormones and Disorders
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renal Diseases and Glomerulopathies
- Central Venous Catheters and Hemodialysis
- Cardiac, Anesthesia and Surgical Outcomes
- Parathyroid Disorders and Treatments
- Electrolyte and hormonal disorders
- Muscle and Compartmental Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Iron Metabolism and Disorders
- Cardiac Arrest and Resuscitation
- Ion Transport and Channel Regulation
- Diet and metabolism studies
- Erythropoietin and Anemia Treatment
- Renal and Vascular Pathologies
- Renal function and acid-base balance
- Liver Disease Diagnosis and Treatment
- Restless Legs Syndrome Research
- Diabetes Treatment and Management
Taipei Medical University
2016-2025
Taipei Tzu Chi Hospital
2015-2025
Taipei Medical University-Shuang Ho Hospital
2017-2024
Ministry of Health and Welfare
2023-2024
National Taiwan University Hospital
2014-2023
Flinders University
2020
National Taiwan University
2008-2019
Universitat Autònoma de Barcelona
2019
Mackay Medical College
2018
China Medical University Hospital
2018
In patients who seek surgical cure of primary aldosteronism (PA), The Endocrine Society Guidelines recommend the use adrenal vein sampling (AVS), which is invasive, technically challenging, difficult to interpret, and commonly held be risky. aim this study was determine complication rate AVS ways in it performed interpreted at major referral centers. Adrenal Vein Sampling International Study an observational, retrospective, multicenter conducted centers for endocrine hypertension worldwide....
The incidence rate of AKI in hospitalized patients is increasing. However, relatively little attention has been paid to the association with long-term risk adverse coronary events. Our study investigated who recovered from de novo dialysis-requiring between 1999 and 2008 using patient data collected inpatient claims Taiwan National Health Insurance. We used Cox regression time-varying covariates adjust for subsequent CKD ESRD after discharge. Results were further validated by analysis a...
Pericytes have been identified as the major source of precursors scar-producing myofibroblasts during kidney fibrosis. The underlying mechanisms triggering pericyte-myofibroblast transition are poorly understood. Transforming growth factor β-1 (TGF-β1) is well recognized a pluripotent cytokine that drives organ We investigated role TGF-β1 in inducing profibrotic signaling from epithelial cells to activate transition. Increased expression was detected predominantly injured epithelium after...
The Ca(2+)-adenosinetriphosphatase pump of the sarcoplasmic or endoplasmic reticulum (SERCA) plays a critical role in Ca2+ signaling and homeostasis all cells is encoded by family homologous alternatively spliced genes. To understand more clearly different isoforms play cell physiology, we have undertaken quantitative qualitative assessment tissue distribution transcripts encoding each SERCA isoform. SERCA1 expression restricted to fast-twitch striated muscles, SERCA2a cardiac slow-twitch...
A cDNA encoding the full-length adult rat fast-twitch muscle Ca(2+)-adenosinetriphosphatase (ATPase) was cloned. The deduced amino acid sequence of this molecule has 97 and 90% identity with those rabbit chicken skeletal Ca(2+)-ATPases, respectively. Specific probes from 3'-untranslated region each sarcoplasmic or endoplasmic reticulum Ca(2+)-ATPase (SERCA) gene product cRNA transcript standards were used to determine quantity mRNA isoform in various muscles. Quantitative immunoblotting also...
Abstract Introduction Abdominal surgery is probably associated with more likelihood to cause acute kidney injury (AKI). The aim of this study was evaluate whether early or late start renal replacement therapy (RRT) defined by simplified RIFLE (sRIFLE) classification in AKI patients after major abdominal will affect outcome. Methods A multicenter prospective observational based on the NSARF ( N ational Taiwan University S urgical ICU ssociated R enal F ailure) Study Group database. 98 (41...
Whether preoperative proteinuria associates with adverse renal outcomes after cardiac surgery is unknown. Here, we performed a secondary analysis of prospectively enrolled cohort adult patients undergoing coronary artery bypass grafting (CABG) at medical center and its two affiliate hospitals between 2003 2007. We excluded stage 5 CKD or those who received dialysis previously. defined proteinuria, measured dipstick, as mild (trace to 1+) heavy (2+ 4+). Among total 1052 patients,...
Background The incidence of acute kidney injury ( AKI ) requiring dialysis in hospitalized patients is increasing; however, information on the long‐term stroke surviving to discharge after recovering from has not been reported. Methods and Results Patients that survived recovery dialysis‐requiring during index hospitalizations 1999 2008 were identified nationwide administrative registries. risk de novo death analyzed with time‐varying Cox proportional hazard models. results validated by a...
Background. Residual renal function (RRF) at the initiation of peritoneal dialysis (PD) therapy can predict patient outcome. However, RRF declines with time variable rates in different patients. This study was performed to compare impact baseline and rate decline on survival death-censored technique after long-term PD.
Fibrosis of the peritoneal cavity remains a serious, life-threatening problem in treatment kidney failure with dialysis. The mechanism fibrosis unclear partly because fibrogenic cells have not been identified certainty. Recent studies proposed mesothelial to be an important source myofibroblasts through epithelial-mesenchymal transition; however, confirmatory vivo are lacking. Here, we show by inducible genetic fate mapping that type I collagen-producing submesothelial fibroblasts specific...
Abstract There exists a great knowledge gap in terms of long-term effects various surgical and pharmacological treatments on outcomes among primary aldosteronism (PA) patients. Using validated algorithm, we extracted longitudinal data for all PA patients diagnosed 1997–2010 treated the Taiwan National Health Insurance. We identified 3362 whom mean length follow-up was 5.75 years. has higher major cardiovascular events (MACE) than essential hypertension (23.3% vs 19.3%, p = 0.015). Results...
Studies addressing the association of metabolic syndrome and insulin resistance with risks incident chronic kidney disease (CKD) progression renal function were either lacking or inconclusive. The aim this study was to define effect on development new CKD decline in function. A prospective cohort conducted at a tertiary university-based hospital Taiwan. We studied total 1456 Asians 65 older who followed for an average 3.15 yr. Within cohort, we measured using homeostasis model assessment...
We sought to measure the clinical benefits of adrenal venous sampling (AVS), a test recommended by guidelines for primary aldosteronism (PA) patients seeking surgical cure, in large registry PA submitted AVS. Data 1625 consecutive AVS 19 tertiary referral centers located Asia, Australia, Europe, and North America were collected multicenter international registry. The end points rate bilateral success, ascertained lateralization PA, adrenalectomy, cured arterial hypertension among AVS-guided...