A5039433631- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Blood Pressure and Hypertension Studies
- Bladder and Urothelial Cancer Treatments
- Dialysis and Renal Disease Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Acute Kidney Injury Research
- Renal cell carcinoma treatment
- Nephrotoxicity and Medicinal Plants
- Urinary and Genital Oncology Studies
- Renal and related cancers
- Cardiac Arrest and Resuscitation
- Prostate Cancer Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Esophageal Cancer Research and Treatment
- Diabetes Treatment and Management
- Ureteral procedures and complications
- Genetic and Kidney Cyst Diseases
- Hormonal and reproductive studies
- Apelin-related biomedical research
- Urological Disorders and Treatments
- Prostate Cancer Treatment and Research
- Gastric Cancer Management and Outcomes
- Infectious Disease Case Reports and Treatments
National Taiwan University Hospital
2015-2025
National Taiwan University
2009-2024
National Health Research Institutes
2014-2024
Tao Yuan General Hospital
2010-2024
First Hospital of Jilin University
2024
Jilin University
2024
Shanghai Municipal Center For Disease Control Prevention
2022
Fu Jen Catholic University
2019
Ministry of Health and Welfare
2018
Chung Yuan Christian University
2018
The incidence rate of AKI in hospitalized patients is increasing. However, relatively little attention has been paid to the association with long-term risk adverse coronary events. Our study investigated who recovered from de novo dialysis-requiring between 1999 and 2008 using patient data collected inpatient claims Taiwan National Health Insurance. We used Cox regression time-varying covariates adjust for subsequent CKD ESRD after discharge. Results were further validated by analysis a...
BackgroundConsumption of Chinese herbs that contain aristolochic acid (eg, Mu Tong) has been associated with an increased risk urinary tract cancer.
Abstract There exists a great knowledge gap in terms of long-term effects various surgical and pharmacological treatments on outcomes among primary aldosteronism (PA) patients. Using validated algorithm, we extracted longitudinal data for all PA patients diagnosed 1997–2010 treated the Taiwan National Health Insurance. We identified 3362 whom mean length follow-up was 5.75 years. has higher major cardiovascular events (MACE) than essential hypertension (23.3% vs 19.3%, p = 0.015). Results...
Abstract Background Frail older adults are predisposed to multiple comorbidities and adverse events. Recent interventional studies have shown that frailty can be improved managed. In this study, effective individualized home-based exercise nutrition interventions were developed for reducing in adults. Methods This study was a four-arm, single-blind, randomized controlled trial conducted between October 2015 June 2017 at Miaoli General Hospital Taiwan. Overall, 319 pre-frail or frail randomly...
Aristolochic acid (AA), a component of all Aristolochia ‐based herbal medicines, is potent nephrotoxin and human carcinogen associated with upper urinary tract urothelial carcinoma (UUC). To investigate the clinical pathological characteristics AA‐induced UUC, this study included 152 UUC patients, 93 whom had been exposed to AA based on presence aristolactam‐DNA adducts in renal cortex. Gene sequencing was used identify tumors A:T‐to‐T:A transversions TP53 , mutational signature AA. Cases...
Even though the increasing clinical recognition of primary aldosteronism (PA) as a public health issue, its heightened risk profiles and availability targeted surgical/medical treatment being more understood, consensus in diagnosis management based on medical evidence, while recognizing constraints our real-world practice Taiwan, has not been reached.The Taiwan Society Aldosteronism (TSA) Task Force acknowledges above-mentioned issues reached this PA at inaugural meeting, order to provide...
Abnormal glucose metabolism due to insulin resistance has been linked aldosterone overproduction. However, the long-term incidence of new-onset diabetes mellitus (NODM) among patients with primary aldosteronism after targeted treatment not well documented.The diagnosis and essential hypertension were identified, then occurrence NODM, all-cause mortality these patients, was ascertained by a validated algorithm from 23-million population insurance registry.From 1999 2007, 2367 without...
Abstract Primary aldosteronism (PA) is the most common secondary hypertension. The best treatment for a lateralized PA unilateral adrenalectomy. Recent studies explored partial adrenalectomy (pAdx) to reduce risk of adrenal insufficiency. However, in cases involving multiple aldosterone-producing micronodules/nodules (mAPM/mAPN), pAdx cannot completely remove all origins excess aldosterone and might not resolve CYP11B2 immunohistochemical staining helps HISTALDO (Histopathology PA)...
Objectives To obtain information about the effect of prolonged aldosterone excess on kidney function. Methods We determined function changes defined by cystatin C-based estimations glomerular filtration rate (CysC-GFR). Pretreatment proteinuria and intrarenal Doppler velocimetric indices in primary aldosteronism were examined followed after adrenalectomy or spironolactone treatment. Results This prospective, multicenter study included 130 patients (56 men; age, 49.9 ± 13.4 years: 100 with...
Abstract Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation calcium channels been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3 ± 12.3years) who received adrenalectomy were collected from Taiwan investigator (TAIPAI) group. A high rate somatic mutation APA was found (n = 91, 61.5%); including...
Constitutive activation of the Wnt pathway/β-catenin signaling may be important in aldosterone-producing adenoma (APA). However, significant gaps remain our understanding prevalence and clinical outcomes after adrenalectomy APA patients harboring CTNNB1 mutations. The molecular expression CYP11B2 gonadal receptors adenomas were also explored. Adenomas from 219 (95 men; 44.2%; aged 50.5 ± 11.9 years) showed a high rate somatic mutations (n = 128, 58.4%). majority them harbored KCNJ5 116,...
ABSTRACT Primary aldosteronism (PA) is associated with increased urinary calcium excretion and osteoporosis prevalence. We studied the long-term effect of hyperaldosterone on fracture risk possible mitigation via treatments, by comparing PA patients their essential hypertension (EH) counterparts extracted propensity score match. used a longitudinal population database from Taiwan National Health Insurance, validated algorithm to identify diagnosed in 1997–2010. Our sample included 2533...
To assess whether angiotensin-II receptor blockers (ARBs) offer any additional advantage in confirming the diagnosis of primary aldosteronism (PA) and their use differentiation PA subtypes.A prospective, cohort, head-to-head study was conducted between July 2003 2006. A total 135 patients received captopril losartan tests to confirm TAIPAI (Taiwan Primary Aldosteronism Investigation) intervention.In total, 71 were diagnosed with PA. The area under receiver-operating characteristic (ROC)...
Primary aldosteronism (PA) is a common cause of secondary hypertension, and the long-term effect excess aldosterone on kidney function unknown.We used longitudinal population database from Taiwan National Health Insurance system applied validated algorithm to identify patients with PA diagnosed between 1997 2009.There were 2699 recruited, whom 761 an aldosterone-producing adenoma (APA) identified. The incidence rate end-stage renal disease (ESRD) was 3% in after targeted treatments 5.2 years...
Long-term outcomes (especially mortality and/or major cardiovascular events (MACE)) of the unilateral primary aldosteronism (uPA) patients who underwent medical or surgery-targeted treatment, relative to those with essential hypertension (EH), have been scarcely reported.Using prospectively designed observational Taiwan Primary Aldosteronism Investigation cohort, we identified 858 uPA cases among 1220 and another 1210 EH controls.Operated were grouped via their 1-year post-therapy...
Abstract Background Sodium-glucose cotransporter 2 inhibitors (SGLT-2is) have demonstrated associations with lowering cardiovascular outcomes in patients type diabetes mellitus (T2DM). However, the impact of SGLT-2is on individuals at dialysis commencement remains unclear. The aim this real-world study is to association between and T2DM commencement. Methods This a retrospective cohort electronic health records (EHRs) from TriNetX Research Network database January 1, 2012, 2024. New-users...
Importance The interplay among baseline kidney function, severity of acute disease (AKD), and post-AKD function has significant associations with patient outcomes. However, a comprehensive understanding how these factors are collectively associated mortality, major adverse cardiac events (MACEs), end-stage (ESKD) in patients dialysis-requiring injury (AKI-D) is yet to be fully explored. Objective To investigate the AKD severity, MACEs, ESKD AKI-D. Design, Setting, Participants This...
Abstract Context The captopril challenge test (CCT) is a commonly used confirmation that identifies the magnitude of renin- and angiotensin II-independent aldosterone production, thus presence severity primary aldosteronism (PA). Objective This study investigated association between post-CCT plasma concentration (PAC) cardiovascular remodeling diastolic dysfunction. Methods A total 540 PA patients with complete CCT echocardiographic data were retrospectively analyzed. Clinical parameters...
To assess the prevalence of visual impairment and rate wearing spectacles in schools for children migrant workers Shanghai, China. Children from grade 1 to 5 were randomly chosen ocular examinations. All screened uncorrected acuity presenting acuity. After screening, whose was 20/40 or less received motility evaluation, cycloplegic refraction/non-cycloplegic refraction, external eye, anterior segment, media, fundus A total 9673 enumerated 9512 (98.34%) participated this study. The...
Background Prolonged mechanical ventilation (PMV) is increasingly common worldwide, consuming enormous healthcare resources. Factors that modify PMV outcome are still obscure. Methods We selected patients without preceding within the one past year and who developed during index admission in Taiwan's National Health Insurance (NHI) system 1998–2007 for comparison of mortality resource use. They were divided into three groups: (1) with end-stage renal diseases (ESRD) before onset; (2)...