A5043871457- Diabetes Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Management and Research
- Lipoproteins and Cardiovascular Health
- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Education
- Hormonal Regulation and Hypertension
- Mosquito-borne diseases and control
- Head and Neck Anomalies
- Metabolism, Diabetes, and Cancer
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Pituitary Gland Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Thyroid and Parathyroid Surgery
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Pharmacology and Obesity Treatment
- Viral Infections and Vectors
- Pancreatic function and diabetes
- Dengue and Mosquito Control Research
National Taiwan University Hospital
2016-2025
National Taiwan University
2013-2025
Anhui Medical University
2024
National Yang Ming Chiao Tung University
2018-2024
First Affiliated Hospital of Anhui Medical University
2024
National Center for Health Statistics
2024
Kaohsiung Chang Gung Memorial Hospital
2011-2022
Chang Gung University
2011-2022
Memorial Hospital of South Bend
2010-2022
Chang Gung Memorial Hospital
2000-2022
Fatty infiltration of the pancreas is an enigmatic manifestation ectopic fat deposition in obesity. Studies have shown that pancreatic lipid accumulation interferes with insulin secretion humans. However, prevalence fatty and its associated factors general population remain unclear. The aim this study was to investigate association diabetes, nonalcoholic liver disease (NAFLD), cardiometabolic risk a Chinese population.This cross-sectional study. A total 8097 subjects or without (n=1297 6800,...
Fatty infiltration of the pancreas has been shown to interfere with insulin secretion. Both sensitivity and secretion are important in pathogenesis diabetes prediabetes. However, relationship between diabetes, prediabetes, fatty remains unknown. We aim investigate relationships that nonalcoholic liver disease (NAFLD) have prediabetes a Chinese population.This was cross-sectional study. A total 7,464 subjects were recruited. NAFLD assessed by sonography. Clinico-metabolic parameters compared...
Fatty liver is associated with insulin resistance, dyslipidemia, and obesity therefore considered a phenotype of metabolic syndrome. However, less known regarding the abnormalities non-alcoholic fatty pancreatic disease (NAFPD; pancreas). The present study was performed to ascertain whether pancreas specific risk factors syndrome as defined by Adult Treatment Panel III.Five-hundred-fifty-seven healthy consecutive subjects without hypertension or diabetes who received health investigation at...
Even though the increasing clinical recognition of primary aldosteronism (PA) as a public health issue, its heightened risk profiles and availability targeted surgical/medical treatment being more understood, consensus in diagnosis management based on medical evidence, while recognizing constraints our real-world practice Taiwan, has not been reached.The Taiwan Society Aldosteronism (TSA) Task Force acknowledges above-mentioned issues reached this PA at inaugural meeting, order to provide...
Abstract Graves’ disease is the leading cause of hyperthyroidism affecting 1.0–1.6% population. Antithyroid drugs are treatment cornerstone, but may life-threatening agranulocytosis. Here we conduct a two-stage association study on two separate subject sets (in total 42 agranulocytosis cases and 1,208 controls), using direct human leukocyte antigen genotyping SNP-based genome-wide study. We demonstrate HLA-B*38:02 (Armitage trend P combined =6.75 × 10 −32 ) HLA-DRB1*08:03 ( =1.83 −9 as...
GLP-1 receptor agonists and SGLT2 inhibitors are increasingly being used in people with type 2 diabetes on the basis of findings from randomised clinical trials; however, little is known whether outcomes affected by frailty real-world settings. We aimed to compare effectiveness safety managing diabetes, a specific focus stratifying their status.
Lovastatin has been used to treat hypercholesterolemia through blocking the mevalonate biosynthesis pathway. Inhibition of synthesis may result in antiproliferation and cell apoptosis. The aim present study was examine apoptotic effect lovastatin human ARO cells delineate its underlying molecular mechanism. Our results showed that dose- time-dependently induced apoptosis cells. Pretreatment with cycloheximide dose-dependently suppressed lovastatin-induced apoptosis, suggesting de novo...
The majority of male infertility results from poor sperm motility. A direct link between altered protein phosphorylation and aberrant motility has not been established. To address this issue, samples obtained 20 donors with healthy aberrantly motile were subjected to computer assisted semen analysis (CASA), proteomic analysis, Western blot, immunofluorescent staining. Proteomic identified 12 spots as having differential phosphorylation, including gamma-tubulin complex associated 2 (GCP2)....
Thyrotropin levels are outside normal reference range in subclinical thyroid disease. Metabolic syndrome (MetS) involves clustered cardiovascular risk factors, including abnormal lipids, insulin resistance, and hypertension. This study aimed to investigate associations between disease, thyrotropin levels, metabolic healthy subjects identify associated biochemical markers. cross-sectional evaluated 9,055 examined at the Health Management Center, National Taiwan University Hospital from...
Circular RNAs (circRNAs) play critical roles in disease incidence. However, the of circRNAs colorectal cancer (CRC) progression remain largely unknown. We explored expression circMTO1 CRC and elucidated underlying molecular mechanisms.Quantitative Real-time-PCR (qRT-PCR) was used to explore tissues cell lines. The effect on biological function cells analyzed by Cell Counting Kit-8 (CCK-8) assay, Edu colony formation wound-healing assay transwell invasion assay. Gene signaling pathway were...
As a part of natural disease progression, acute kidney injury (AKI) can develop into chronic via renal fibrosis and inflammation. LTBP4 (latent transforming growth factor beta binding protein 4) regulates beta, which plays role in pathogenesis. We previously investigated the disease. Here, we examined AKI.LTBP4 expression was evaluated human tissues, obtained from healthy individuals patients with AKI, using immunohistochemistry. knocked down both C57BL/6 mice proximal tubular cell line...
Abstract Aims Early dipeptidyl peptidase‐4 inhibitors and metformin (DPP4i‐Met) combination has been shown to extend the time treatment failure provide better glycaemic control for newly diagnosed type 2 diabetes (T2D) patients; however, long‐term clinical economic outcomes of early DPP4i‐Met remain unknown. We seek assess comparative cost‐effectiveness versus Met treatment‐naïve T2D patients with inadequately controlled HbA1c (i.e., ≥8.5%). Methods The IQVIA CORE Diabetes Model was used...
ABSTRACT Background Distant metastasis is a leading cause of thyroid cancer (TC)‐related deaths. Genetic profiling typically limited to one sample per patient due cost and sampling‐risk concerns. Differences between samples from distant within individual patients are unclear. Methods Patients with TC were recruited for genetic analysis. Results Using TC‐specific NGS panel, 66 specimens 29 analyzed, identifying 16 mutations 4 fusions, including two novel fusions ( FGFR2–SHTN1 RFTN1–BRAF )....
Lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, inhibits the conversion mevalonate from HMG-CoA. Previously, we have reported that lovastatin treatment induced occurrence apoptosis and differentiation in ARO anaplastic thyroid cancer cells. Here, demonstrated inhibited cell invasiveness delineated underlying molecular mechanism. Lovastatin significantly suppressed EGF-induced adhesion, actin filament reorganization transmigration. also reduced increases...