A5024055768- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Economics and Policy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Acute Ischemic Stroke Management
- Asthma and respiratory diseases
- Inflammasome and immune disorders
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Autoimmune and Inflammatory Disorders Research
- Economic and Environmental Valuation
- Lung Cancer Treatments and Mutations
- Pharmaceutical Practices and Patient Outcomes
- Trauma Management and Diagnosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Light effects on plants
- Cardiac Arrhythmias and Treatments
- Lymphoma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
National Taiwan University
2016-2025
National Taiwan University Hospital
2017-2025
Capital Medical University
2011-2024
Fujian Provincial Hospital
2024
Beijing Shijingshan Hospital
2019-2024
Taipei Medical University-Shuang Ho Hospital
2023
Institute of Clinical Research
2017-2023
Fujian Provincial Cancer Hospital
2023
Fujian Medical University
2023
Institute of Chemistry, Academia Sinica
2023
Multifunctional superhydrophobic nanocomposite surfaces based on photocatalytic materials, such as fluorosilane modified TiO2, have generated significant research interest. However, there are two challenges to forming multifunctional with stable properties: the oxidation of hydrophobic functional groups, which leads permanent loss superhydrophobicity, well photoinduced reversible hydrolysis catalytic particle surface. Herein, we report a simple and inexpensive template lamination method...
<h3>Objective</h3> To examine whether plasma neurofilament light chain (NfL) levels were associated with motor and cognitive progression in Parkinson disease (PD). <h3>Methods</h3> This prospective follow-up study enrolled 178 participants, including 116 PD, 22 multiple system atrophy (MSA), 40 healthy controls. We measured NfL electrochemiluminescence immunoassay. Patients PD received evaluations of cognition at baseline a mean interval 3 years. Changes the Unified Parkinson9s Disease...
Oscillations of the period (per) andtimeless (tim) gene products are an integral part feedback loop that underlies circadian behavioral rhythms in Drosophila melanogaster. Resetting this response to light requires putative photoreceptor cryptochrome (CRY). We dissected early events photic resetting by determining mechanisms underlying CRY and investigating relationship between light-induced ubiquitination TIM protein. In light, is degraded proteasome through a mechanism electron transport....
<b>Objective:</b> To determine the type 1 T helper (Th1)/type 2 (Th2) balance in peripheral blood (PB) and pathological tissues of patients with active untreated adult onset Still's disease (AOSD). <b>Methods:</b> The percentages interferon γ (IFNγ)- interleukin (IL)4-producing Th cells PB 20 AOSD, rheumatoid arthritis (RA), healthy controls were determined by intracellular staining flow cytometry. Serum levels IL18 soluble IL2 receptor measured enzyme linked immunosorbent assay. Levels IFNγ...
Little is known about the differences in immunopathogenesis between elderly-onset rheumatoid arthritis (EORA) and younger-onset RA (YORA) factors responsible for their clinical characteristics.It was aim of this study to investigate proinflammatory cytokines EORA patients compare them with those YORA patients.Serum levels interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor (TNF)-alpha interferon (IFN)-gamma were determined by cytometric bead array 86 active EORA, 76 30 healthy...
Two different molecular weights of poly(methyl methacrylate) (PMMA) and PMMA containing polyhedral oligomeric silsesquioxane (PMMA−POSS) homopolymers have been prepared via the atom transfer radical polymerization (ATRP) technique. The miscibility specific interaction behaviors PMMA−POSS with phenolic resin were investigated by differential scanning calorimetry Fourier transform infrared spectroscopy (FTIR). FTIR results reveal that at least three competing equilibriums are present in...
The Patient Reported Outcomes Measurement Information System 43-item short form (PROMIS-43) and the five-level EQ-5D (EQ-5D-5L) are recently developed measures of health-related quality life (HRQL) that have potentially broad application in evaluating treatments capturing burden respiratory-related diseases. aims this study were: (1) to examine their psychometric properties patients with chronic obstructive pulmonary disease (COPD), (2) identify dimensions HRQL differ do not by lung...
A prospective observational study was conducted to investigate the residual risk factors predict recurrence of major adverse cardiovascular events (MACE) in atherosclerotic disease (ASCVD) patients with a high prevalence under lipid-lowering therapy, particularly subpopulations diabetic and nondiabetic individuals. total 5,483 adults (with mean age 66.4 73.3% male) established coronary heart disease, cerebrovascular or peripheral artery were identified from T-SPARCLE multi-center registry....
Objectives To date, a value set for the EQ-5D-5L based on health state preferences of general Taiwanese population has not been available. This study aimed to develop facilitate technology assessment medical products and services. Methods An international standardized protocol valuation studies developed by EuroQol group was adopted. Adult members public were recruited from six geographic regions in Taiwan. In computer-based face-to-face interviews, each participant completed 10 composite...
To identify cardiovascular (CV) risk factors in Asian elderly aged 75 years and older subsequently develop validate a sex-specific five-year CV assessment tool for this population. This study included 12,174 patients ≥ without prior history of disease at single hospital Taiwan. Electronic health records were linked to the National Health Insurance Research Database Death Registry ensure comprehensive information. Eligible randomly divided into derivation (80%) validation (20%) cohorts. A was...
This purpose of this study is to analyze the influence levetiracetam (LEV) on direct oral anticoagulant (DOAC) exposure and its implications for clinical outcomes. investigation comprised a retrospective cohort utilizing integrated medical database prospective observational conducted in tertiary hospital. Patients aged >65 years with atrial fibrillation undergoing DOAC therapy were included categorized as LEV users non-users based status. In cohort, outcomes between compared, ischemic stroke...
<b><i>Background/Aims:</i></b><b><i></i></b> Limited evidence exists on the choice of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in diabetic patients with nephropathy. We aim to assess renal effectiveness safety these drugs among nephropathy patients. <b><i>Methods:</i></b><b><i></i></b> This retrospective cohort study was conducted who initiated...
To investigate the association of intercellular adhesion molecule 1 (ICAM-1) with clinical manifestations and interleukin-18 (IL-18) levels in patients active untreated adult-onset Still's disease (AOSD).We determined serum soluble ICAM-1 (sICAM-1) by enzyme-linked immunosorbent assay 50 AOSD, 20 rheumatoid arthritis (RA), healthy controls. The messenger RNA expression IL-18-stimulated peripheral blood mononuclear cells (PBMCs) biopsy specimens obtained from AOSD rash or synovitis were...
Journal Article Effects of clinical decision support on venous thromboembolism risk assessment, prophylaxis, and prevention at a university teaching hospital Get access William L. Galanter, M.D., Ph.D., Ph.D. Assistant Professor Clinical Medicine College Medicine, Section General Internal University Illinois Hospital Information Services, Pharmacy Practice, Department Pharmacy, Chicago (UIC). Search for other works by this author on: Oxford Academic Google Scholar Mathew Thambi, Pharm.D.,...
Mucopolysaccharidosis type II (MPS II) is an X-linked recessive, multisystemic lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase. MPS has variable age onset and rate progression. In Asian countries, there relatively higher incidence compared to other types MPS. A retrospective analysis was carried out 34 Taiwanese patients who died between 1995 2012. The clinical characteristics, medical records, at death, cause death were evaluated better understand the natural...
Background To investigate the effectiveness and safety of withholding or restarting antithrombotic agents, different therapies among patients with atrial fibrillation post-intracranial hemorrhage. Methods Results This is a nationwide retrospective cohort study involving receiving who subsequently developed intracranial hemorrhage between January 1, 2011 December 31, 2017. The risk ischemic stroke (IS), recurrent intracerebral (ICH), all-cause mortality were investigated no treatment versus...