Available information suggests a mismatch between radiographic and orthopedic examination findings in cats with DJD. However, the extent of discrepancy clinical signs OA companion animals has not been described detail. This study aimed to evaluate relationship findings, joint goniometry, DJD 100 cats, prospective observational design. Cat temperament, pain response palpation, crepitus, effusion thickening were graded. Radiographs appendicular joints axial skeleton made under sedation. Joint...

Prior observational studies have suggested that fluoroquinolone use may be associated with more than 2-fold increased risk of aortic aneurysm or dissection (AA/AD). These studies, however, did not fully consider the role coexisting infections and fluoroquinolones relative to other antibiotics.To estimate AA/AD assess comparative vs antibiotics similar indication profiles among patients same types infections.This nested case-control study identified 21 651 176 adult from a nationwide...

The high molecular weight mucin-like glycoprotein, DF3 (MUC1), is overexpressed in the majority of human breast cancers. Here we demonstrate that replication defective recombinant adenoviral vectors, containing promoter (bp -725 to +31), can be used express beta-galactosidase (Ad.DF3-betagal) and herpes simplex virus thymidine kinase (HSV-tk) gene (Ad.Df3-tk) positive carcinoma cell lines. In vivo experiments using tumor implants nude mice injected with Ad.DF3-betagal demonstrated expression...

Automated pharmacy claim data have been used for risk adjustment on health care utilization. However, most published pharmacy-based morbidity measures incorporate a coding algorithm that requires the medication to be coded using US National Drug Codes or American Hospital Formulary Service drug codes, making studies conducted outside operationally cumbersome.This study aimed verify metric with World Health Organization (WHO) Anatomical Therapeutic Chemical (ATC) can explain variations in...

<b>Objective</b>&nbsp;To compare differences in mortality between women concomitantly treated with tamoxifen and selective serotonin reuptake inhibitors (SSRIs) that are potent of the cytochrome-P450 2D6 enzyme (CYP2D6) versus other SSRIs. <b>Design</b>&nbsp;Population based cohort study. <b>Setting</b>&nbsp;Five US databases covering individuals enrolled private public health insurance programs from 1995 to 2013. <b>Participants</b>&nbsp;Two cohorts who started taking tamoxifen. In 1, an...

Medication nonadherence is a major public health problem. Identification of patients who are likely to be and not adherent can guide targeted interventions improve the design comparative-effectiveness studies.To evaluate multiple measures patient previous medication adherence in light predicting future statin large U.S. administrative claims database.We identified cohort newly initiating statins measured their other chronic preventive medications during 365-day baseline period, using metrics...

Multiple case reports suggest that olmesartan may be linked to sprue-like enteropathy; however, few epidemiological studies have examined this association and results been mixed.To assess whether is associated with a higher rate of enteropathy vs other angiotensin II receptor blockers (ARBs).We conducted cohort study among ARB initiators in 5 US claims databases representing different health insurance programmes. Cox regression models were used estimate hazard ratios (HRs) 95% confidence...

Background To investigate the effectiveness and safety of withholding or restarting antithrombotic agents, different therapies among patients with atrial fibrillation post-intracranial hemorrhage. Methods Results This is a nationwide retrospective cohort study involving receiving who subsequently developed intracranial hemorrhage between January 1, 2011 December 31, 2017. The risk ischemic stroke (IS), recurrent intracerebral (ICH), all-cause mortality were investigated no treatment versus...

Study Objective Inhaled long-acting bronchodilators are commonly used as maintenance therapy in chronic obstructive pulmonary disease (COPD). We compared the risk of cardiovascular and cerebrovascular events among patients with COPD treated inhaled bronchodilator monotherapy combination therapy. Design Retrospective cohort study. Settings A population-based health care database from Taiwan. Patients Individuals who initiated muscarinic antagonists (LAMAs) alone, β-2 agonists (LABA) LABA LAMA...

Abstract Background Patients treated with warfarin are often coprescribed selective serotonin reuptake inhibitors (SSRIs) for coexisting depression. Some SSRIs potent CYP2C9 that may increase plasma concentrations and the risk of bleeding. We aimed to examine effect putative CYP2C9-mediated warfarin-SSRI interaction on clinical outcomes. Methods conducted an observational cohort study among initiators who had a subsequent SSRI prescription in 5 US claims databases. were followed up 180 days...

Clinical trials have suggested that glucagon-like peptide-1 receptor agonists (GLP-1RAs) may be associated with a higher risk of biliary-related diseases in patients type 2 diabetes. Limited real-world studies examined the comparative biliary safety GLP-1RAs versus other antihyperglycemic drugs. We aimed to estimate between and sodium glucose cotransporter inhibitors (SGLT2is), which are indicated for similar diabetes severity Taiwan.Retrospective cohort study.Taiwan National Health...

Background Proton-pump inhibitors (PPIs) are prescribed to treat gastric acid - related diseases, while they may also have potential risks population health. Recent studies suggested that a mechanism explaining the association between PPIs and cardiovascular diseases (CVD) includes inhibition of nitrate nitrite nitric oxide (NO) pathway. However, previous observational showed controversial results association. In addition, NO pathway due use lead peripheral vascular (PVD); however, none...

Abstract Purpose Early-onset breast cancer incidence has been increasing globally and in Taiwan. However, previous studies have not comprehensively examined how clinical lifestyle characteristics influence the 5-year survival of diagnosed at different stages adulthood. Methods We analyzed Taiwan National Cancer Registry Cause Death datasets to understand factors (including tumor treatment characteristics) body mass index, cigarette smoking, alcohol consumption) were associated with 8471...

What is known and objective Pharmacy claims are commonly used to assess medication adherence. It unclear how different approaches handling hospitalizations compare the gold standard of using outpatient inpatient drug data. This study aimed impact on adherence estimation in administrative Methods We identified β-blocker initiators after myocardial infarction (MI) statin regardless hospitalization histories population-based, Taiwan database, which includes Adherence β-blockers or statins...

The new user cohort design is widely used to assess the effects of a drug, such as dabigatran, but inherently excludes some users due prior use comparator for example warfarin. prevalent new-user offers solution that includes all eligible drug.To evaluate safety and effectiveness dabigatran versus warfarin in non-valvular atrial fibrillation (NVAF) patients with design.Taiwan National Health Insurance mortality data from 2011 through 2015 were utilized. From an incident NVAF cohort, we...

Previous studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with higher cardiovascular risks. However, few been active comparison directly assessed the potential differential risk between NSAID classes or across individual NSAIDs. We compared of major events cyclooxygenase 2 (COX-2)-selective and nonselective NSAIDs in patients hypertension.We conducted a cohort study hypertension who initiated COX-2-selective population-based Taiwanese database. The...

Objectives A number of observational studies have reported that, in patients with chronic obstructive pulmonary disease (COPD), β blockers (BBs) decrease risk mortality and COPD exacerbations. To address important methodological concerns these studies, we compared the effectiveness safety cardioselective BBs versus non-dihydropyridine calcium channel (non-DHP CCBs) acute coronary syndromes (ACS) using a propensity score (PS)-matched, active comparator, new user design. We also assessed for...