A5091282674- Medication Adherence and Compliance
- Pharmaceutical Economics and Policy
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Blood Pressure and Hypertension Studies
- Healthcare Policy and Management
- Pharmaceutical studies and practices
- Pharmaceutical industry and healthcare
- Mobile Health and mHealth Applications
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Bipolar Disorder and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Primary Care and Health Outcomes
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Diabetes Management and Research
- Health Literacy and Information Accessibility
- Healthcare cost, quality, practices
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Peripheral Artery Disease Management
- Meta-analysis and systematic reviews
Harvard University
2016-2025
Brigham and Women's Hospital
2016-2025
Analysis Group (United States)
2024
Blue Cross Blue Shield of Massachusetts
2024
Dartmouth College
2024
University of Southern California
2024
Pharmacoeconomics and Health Outcomes Research Iberia (Spain)
2016-2021
VA Boston Healthcare System
2020
Cambridge Cardiac Care Centre
2017-2018
Massachusetts General Hospital
2011-2017
Adherence to medications that are prescribed after myocardial infarction is poor. Eliminating out-of-pocket costs may increase adherence and improve outcomes.
Increasing contact has been reported between physicians and the pharmaceutical industry, although no data exist in literature regarding potential financial conflicts of interest for authors clinical practice guidelines (CPGs). These interactions may be particularly relevant since CPGs are designed to influence a large number physicians.To quantify extent nature industry.Cross-sectional survey 192 44 endorsed by North American European societies on common adult diseases published 1991 July...
Patients with chronic limb-threatening ischemia (CLTI) require revascularization to improve limb perfusion and thereby limit the risk of amputation. It is uncertain whether an initial strategy endovascular therapy or surgical for CLTI superior improving outcomes.
Prescription Refill Management and Its Effect on Adherence: Comment "The Implications of Therapeutic Complexity Adherence to Cardiovascular Medications"
Medication nonadherence accounts for up to half of uncontrolled hypertension. Smartphone applications (apps) that aim improve adherence are widely available but have not been rigorously evaluated.To determine if the Medisafe smartphone app improves self-reported medication and blood pressure control.This was a 2-arm, randomized clinical trial (Medication Adherence Improvement Support App For Engagement-Blood Pressure [MedISAFE-BP]). Participants were recruited through an online platform...
Although generally recommended in atrial fibrillation (AF) patients, the effectiveness and safety of oral anticoagulation dialysis patients with AF is unknown.We assembled a cohort older hemodialysis who initiated without prior record had prescription drug benefits through three state-administered programs. The index event was first hospitalization diagnosed AF; any recorded warfarin use were excluded. Eligible survived ≥30 days from discharge, new records during that 30-day window....
Classifying medication adherence is important for efficiently targeting improvement interventions. The purpose of this study was to evaluate the use a novel method, group-based trajectory models, classifying patients by their long-term adherence.We identified who initiated statin between June 1, 2006 and May 30, 2007 in prescription claims from CVS Caremark evaluated over subsequent 15 months. We compared several summary measures, including proportion days covered (PDC) models with 2-6...
Critical limb ischemia (CLI) is increasing in prevalence, and remains a significant source of mortality loss. The decision to recommend surgical or endovascular revascularization for patients who are candidates both varies significantly among providers driven more by individual preference than scientific evidence.The Best Endovascular Versus Surgical Therapy Patients With Limb Ischemia (BEST-CLI) Trial prospective, randomized, multidisciplinary, controlled, superiority trial designed compare...
Background: New regimens for hepatitis C virus (HCV) have shorter treatment durations and increased rates of sustained virologic response compared with existing therapies but are extremely expensive. Objective: To evaluate the cost-effectiveness these treatments under different assumptions about their price efficacy. Design: Discrete-event simulation. Data Sources: Published literature. Target Population: Treatment-naive patients infected chronic HCV genotype 1, 2, or 3. Time Horizon:...
Forgetfulness is a major contributor to nonadherence chronic disease medications and could be addressed with medication reminder devices.To compare the effect of 3 low-cost devices on adherence.This 4-arm, block-randomized clinical trial involved 53 480 enrollees CVS Caremark, pharmacy benefit manager, across United States. Eligible participants were aged 18 64 years taking 1 oral for long-term use. Participants had suboptimally adherent all their prescribed therapies (with possession ratio...
Insurers and policymakers encourage the use of generic drugs to reduce costs, but generics remain underused. We conducted a national survey commercially insured adults evaluate their perceptions about drugs. Patients agreed that are less expensive better value than brand-name drugs, just as safe. However, although 56 percent reported Americans should more generics, only 37.6 prefer take generics. discuss communicating with practitioners substitution, policymakers' role in influencing use....
Recent studies have raised concerns about the reduced efficacy of clopidogrel when used concurrently with proton pump inhibitors (PPIs), but those may overestimated risk.We studied potential for increased risk adverse cardiovascular events among users versus without concurrent use PPIs in 3 large cohorts patients > or =65 years age, treated between 2001 and 2005. All had undergone percutaneous coronary intervention been hospitalized acute syndrome Pennsylvania, New Jersey, British Columbia,...