A5101789890- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac electrophysiology and arrhythmias
- Chinese history and philosophy
- Diabetic Foot Ulcer Assessment and Management
- Hemophilia Treatment and Research
- Anesthesia and Sedative Agents
- Parkinson's Disease Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Liver Disease Diagnosis and Treatment
- Restless Legs Syndrome Research
- Renal Transplantation Outcomes and Treatments
- Cardiac tumors and thrombi
- Fungal Biology and Applications
- Diabetes Management and Research
- Shoulder Injury and Treatment
- Sleep and Wakefulness Research
- Autoimmune Bullous Skin Diseases
- Heart Failure Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Click Chemistry and Applications
National Taiwan University
2015-2025
National Taiwan University Hospital
2015-2025
Taipei Medical University-Shuang Ho Hospital
2023
Linkou Chang Gung Memorial Hospital
2020-2021
Chang Gung University
2007-2021
Kyiv City Clinical Oncology Center
2019
Taipei Medical University
2014-2016
Taipei Medical University Hospital
2014-2016
University of California, San Francisco
2015
China Medical University Hospital
2014
Diabetic retinopathy (DR) is a leading cause of preventable blindness in adults. To identify genetic contributions DR, we studied 2071 type 2 diabetics. We first conducted genome-wide association study 1007 individuals, comparing 570 subjects with ≥8 years duration without DR (controls) 437 PDR (cases) the Chinese discovery cohort. Cases and controls were similar for HbA1c, diabetes body mass index. Association analysis imputed data identified three novel loci: TBC1D4-COMMD6-UCHL3...
Summary Background The impact of diabetes for hepatocellular carcinoma ( HCC ) development in chronic hepatitis C CHC patients remains controversial. Aim To investigate the risk who develop new onset diabetes. Methods We conducted a nation‐wide cohort study by using Taiwanese National Health Insurance Research Database, which comprised data from >99% entire population. Among randomly sampled one million enrollees, 6251 adult were identified 1997 to 2009. Diabetes was defined as patient...
Mannitol, an osmotic diuretic, is commonly used to treat patients with acute brain edema, but its use also increases the risk of developing kidney injury (AKI). In this study, we investigated incidence and factors mannitol-related AKI in stroke patients. A total 432 (ischemic 62.3%) >20 years age who were admitted neurocritical care center a tertiary hospital received mannitol treatment enrolled study. Clinical parameters including scores National Institutes Health Stroke Scale (NIHSS) at...
Background and purpose Restless legs syndrome ( RLS ) is an underestimated movement disorder in patients with end‐stage renal disease ESRD ). Several clinical laboratory factors were inconsistently reported to associate . We aim perform a large‐scale multicenter study investigate the possible associated risk of Taiwan, country highest incidence uremia world. Methods From October 2009 2011, we constitutively recruited 1130 from 17 hemodialysis centers. Demographic, data, presence severity...
A real‐world association between direct oral anticoagulant (DOAC) concentration and clinical outcomes among Asian patients with atrial fibrillation (AF) is reported herein. Patients AF aged ≥ 20 years who used DOAC for 3 days were enrolled. Trough peak concentrations measured compared the expected range in trials. The Cox proportional hazard model was to investigate outcomes. From January 2016 July 2022, a total of 859 Among them, 22.5%, 24.7%, 36.4%, 16.4% on dabigatran, rivaroxaban,...
This purpose of this study is to analyze the influence levetiracetam (LEV) on direct oral anticoagulant (DOAC) exposure and its implications for clinical outcomes. investigation comprised a retrospective cohort utilizing integrated medical database prospective observational conducted in tertiary hospital. Patients aged >65 years with atrial fibrillation undergoing DOAC therapy were included categorized as LEV users non-users based status. In cohort, outcomes between compared, ischemic stroke...
This study aimed to analyze differences in the exposure-response relationship for factor Xa inhibitors (FXaI) between patients aged ≥ 80 and < years. Patients with atrial fibrillation (AF) taking rivaroxaban, apixaban, or edoxaban were enrolled, a single steady-state trough concentration was measured. FXaI concentrations compared expected range reported clinical trials define high low drug levels. The primary outcome major bleeding, secondary ischemic stroke transient attack (IS/TIA). From...
To evaluate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in patients with diabetic foot ulcer (DFU) Taiwan, and to assess concordance between colonizing clinical MRSA isolates from patients. A total 354 specimens were collected 112 242 without ulcer, respectively. DFU wound cultures for comparison. Nasal rate S. was similar (15.2% vs. 16.9% 5.4% 1.7% MRSA). colonization an independent predictor infection (Odds ratio [OR]: 5.33, 95% confidence interval...
Earlier studies suggested an association between idiopathic restless legs syndrome (RLS) and cardiovascular diseases. However, the risk of events in patients with secondary RLS due to end-stage renal disease (ESRD) is unclear. Our aim was examine whether ESRD had increased cardio/cerebrovascular mortality.In all, 1093 were recruited 2009 2010. The diagnosis severity assessed a face-to-face interview. occurrence death confirmed by medical record review. outcomes interest examined using...
Background and purpose Orolingual angioedema ( OA ) is an uncommon but potentially life‐threatening complication of treatment with recombinant tissue plasminogen activator (rt‐ PA ; alteplase) during acute ischaemic stroke. This study aimed to determine the incidence rt‐ ‐related in Asian stroke population risk pre‐stroke anti‐hypertensive drug use for development this complication. Methods A multi‐center registry was used identify medications patients receiving intravenous from January 2002...
Background To investigate the effectiveness and safety of withholding or restarting antithrombotic agents, different therapies among patients with atrial fibrillation post-intracranial hemorrhage. Methods Results This is a nationwide retrospective cohort study involving receiving who subsequently developed intracranial hemorrhage between January 1, 2011 December 31, 2017. The risk ischemic stroke (IS), recurrent intracerebral (ICH), all-cause mortality were investigated no treatment versus...
The optimal antithrombotic strategies for patients with atrial fibrillation who experience ischemic stroke (IS) despite direct oral anticoagulant (DOAC) therapy remain inconclusive. This study compared outcomes DOAC treatment failure changed or retained their prestroke DOAC.
This study aims to measure the plasma levels of rivaroxaban and apixaban among Asian patients with atrial fibrillation compare results expected drug from clinical studies. A total 73 taking 105 were enrolled. Peak trough measured using ultra-high performance liquid chromatography tandem mass spectrometry. The percentage those within range reported in studies was significantly higher group than group, both for (84.8% vs. 64.4%; P = 0.002) peak (76.9% 33.8%; < 0.001). After adjusting age, sex,...
Amiodarone increases exposure of direct oral anticoagulants (DOACs). We aimed to analyze the effects concurrent amiodarone use on DOAC concentrations and clinical outcomes. Patients who were ≥20 years age, had atrial fibrillation, took enrolled provide trough peak samples for concentration measurements using ultra-high-performance liquid chromatography-tandem mass spectrometry. The results compared with reported in trials define above, within, or under expected range. outcomes interest major...
The objective of this study is to evaluate the effectiveness different rivaroxaban dosage regimens in preventing ischemic stroke and systemic thromboembolism among Asians. A retrospective cohort was conducted on data from nationwide insurance claims Taiwan. Patients with non-valvular atrial fibrillation under warfarin or therapy were included. Propensity score matching used balance covariates, Cox-proportional hazard models applied compare safety each treatment group. Rivaroxaban associated...
Haemophilic arthropathy (HA) is a major complication in patients with haemophilia (PWH), but the study of age-specific prevalence and severity HA very limited Asian countries.This retrospectively reviewed 146 severe- moderate-type Taiwanese PWH aged 4-73 years, roentgenograms elbows, knees ankles calculated Pettersson scores.The HA, mean number HAs per patient scores all joints were 42.8%, 1.3 1.9 points 4-10 years; 64.3%, 1.4 4.1 11-19 97.1%, 2.9 15.6 20-29 93.1%, 4.4 33.1 30-39 100%, 5.1...
The optimal dose of Direct oral anticoagulants (DOACs) to prevent ischemic stroke (IS) and systemic thromboembolism (STE) in atrial fibrillation (AF) patients with a predisposing bleeding risk remains unclear. To compare the effectiveness safety different DOAC dosage regimens AF high but low thrombosis risk. This retrospective, observational study was conducted National Health Insurance claims database Taiwan include aged 20 <75 years, under therapy, had CHA2DS2-VASc score 1 for male 2...
Background and purpose Recent genome‐wide association studies have shown associations between multiple genetic variants primary restless legs syndrome ( RLS ). Their roles in end stage renal disease ESRD ) related secondary are not clear Asian populations scarce. The candidate uremic was investigated a large cohort of T aiwanese dialysis patients. Methods Sixteen ‐related at six loci, including MEIS 1 , BTBD 9 MAP 2K5/ SKOR PTPRD TOX 3 / BC 034767 the intergenic region chromosome 2p14, total...
This study aimed to investigate the association between direct oral anticoagulant (DOAC) concentration upon acute ischemic stroke (IS) or intracranial hemorrhage (ICH) and outcomes.Patients aged ≥20 years treated with DOACs, including dabigatran, rivaroxaban, apixaban, edoxaban, developed IS ICH were enrolled measure DOAC at time of hospital presentation by using ultrahigh-performance liquid chromatography tandem mass spectrometry. Ischemic patients was categorized into low (<50 ng/mL)...
Hemorrhoidectomy usually leads to severe postoperative pain that often causes urinary retention. Topical EMLA cream (lidocaine 2.5% and prilocaine 2.5%) has been used extensively in the clinical setting. This prospective study tested effectiveness of for control after hemorrhoidectomy.Thirty patients admitted hemorrhoidectomy were enrolled randomly assigned into either a group (n = 15) or 15). Postoperatively, received approximately 5 g neomycin ointment, EMLA. A visual analog scale (VAS)...
Dabigatran is effective in preventing ischemic stroke and systemic embolism patients with atrial fibrillation. Although the therapeutic window for dabigatran wide, its pharmacokinetic properties can differ between specific populations. This study aimed to establish a real-life plasma concentration database investigate potential factors affecting this Asians.Patients under therapy were recruited. Plasma was determined trough peak blood samples by using ultra-high performance liquid...