A5074148043- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Advanced Image and Video Retrieval Techniques
- Ultrasound and Hyperthermia Applications
- Genetic Neurodegenerative Diseases
- Video Analysis and Summarization
- Muscle activation and electromyography studies
- Botulinum Toxin and Related Neurological Disorders
- Image Retrieval and Classification Techniques
- EEG and Brain-Computer Interfaces
- Vestibular and auditory disorders
- Heavy Metal Exposure and Toxicity
- Photoacoustic and Ultrasonic Imaging
- Pneumocystis jirovecii pneumonia detection and treatment
- Natural Language Processing Techniques
- Fungal Infections and Studies
- Cerebrovascular and Carotid Artery Diseases
- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- Syphilis Diagnosis and Treatment
- Traffic Prediction and Management Techniques
- Bacillus and Francisella bacterial research
- Antifungal resistance and susceptibility
National Taiwan University Hospital
2016-2025
National Taiwan University
2001-2024
University of Toronto
2022
Weatherford College
2022
Academia Sinica
2017-2021
National Cheng Kung University
2014-2021
Toronto Western Hospital
2021
Krembil Research Institute
2019-2020
University Health Network
2019-2020
Chang Gung University
2009
Low-intensity transcranial ultrasound (TUS) can non-invasively modulate human neural activity. We investigated how different fundamental sonication parameters influence the effects of TUS on motor cortex (M1) 16 healthy subjects by probing cortico-cortical excitability and behavior. A low-intensity 500 kHz transducer was coupled to a magnetic stimulation (TMS) coil. TMS delivered 10 ms before end left M1 hotspot first dorsal interosseous muscle. Varying acoustic (pulse repetition frequency,...
Electrophysiological studies can provide objective and quantifiable assessments of movement disorders. They are useful in the diagnosis hyperkinetic disorders, particularly tremors myoclonus. The most commonly used measures surface electromyography (sEMG), electroencephalography (EEG) accelerometry. Frequency coherence analyses sEMG signals may reveal nature source tremors. effects voluntary tapping, ballistic movements weighting limbs help to distinguish between organic functional presence...
Huntington's disease (HD) is an autosomal-dominant degenerative caused by a cytosine-adenine-guanine trinucleotide expansion in the Huntingtin (htt) gene. The most vulnerable brain areas to mutant HTT-evoked toxicity are striatum and cortex. In spite of extensive efforts that have been devoted characterization HD pathogenesis, no disease-modifying therapy for currently available. A2A adenosine receptor (A2AR) widely distributed brain, with highest level observed striatum. We previously...
This paper investigates the transportation and vehicular modes classification by using big data from smartphone sensors. The three types of sensors used in this include accelerometer, magnetometer, gyroscope. study proposes improved features uses machine learning algorithms including decision trees, K-nearest neighbor, support vector to classify user's modes. In experiments, we discussed compared performance different perspectives accuracy for both modes, executive time, model size. Results...
Journal Article Accepted manuscript Consistently higher seroresponse to benzathine penicillin G (BPG) combined with doxycycline versus BPG alone for early syphilis Get access Kai-Hsiang Chen, Chen Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Search other works by this author on: Oxford Academic PubMed Google Scholar Kuan-Yin Lin, Lin and College Taipei, Corresponding author: MD, MPH, Hospital, 7 Chung-Shan South Road, Taiwan, E-mail: [email...
The data on immune responses of individuals undergoing MVA-BN vaccination are scarce. We aimed to compare Mpox virus-specific antibody and neutralizing among people with without HIV receiving vaccines. This prospective study enrolled participants two-dose investigate seroresponses after vaccination. Blood samples were collected before each dose for determinations anti-A29 anti-H3 IgG. Neutralization tests conducted tested positive both Overall, 441 enrolled. Seroconversion IgG, respectively,...
Reports suggest that catechol-O-methyltransferase (COMT(L/L)) (Val(158)/Met) and monoamine oxidase B (MAOB) intron 13 genotype polymorphism is associated with PD. To understand the ethnicity-specific effects of genetic polymorphism, we performed a case-control study association between PD susceptibility MAOB COMT, both separately in combination, Taiwanese.Two hundred twenty-four patients 197 controls, matched for age, sex, birthplace, were recruited. COMT genotyping was by using PCR-based...
Previous research suggest that repeated lead-chelation therapy decelerates progression of renal insufficiency in non-diabetic (non-DM) patients with high-normal body lead burden (BLB). Study findings are limited by relatively short-term follow-up and small sample size.A total 116 non-DM chronic kidney diseases (serum creatinine level 1.5-3.9 mg/dl), BLB (>60 microg <600 microg) no exposure history were randomly assigned to a chelation or control group this 4-year clinical trial. For 3...
Background and purpose Orolingual angioedema ( OA ) is an uncommon but potentially life‐threatening complication of treatment with recombinant tissue plasminogen activator (rt‐ PA ; alteplase) during acute ischaemic stroke. This study aimed to determine the incidence rt‐ ‐related in Asian stroke population risk pre‐stroke anti‐hypertensive drug use for development this complication. Methods A multi‐center registry was used identify medications patients receiving intravenous from January 2002...
Spiral drawing on papers is a common tremor evaluation tool for diagnosing patients with essential (ET) or Parkinson's disease (PD). No standard methods and parameters that use graphic tablets are yet available objective evaluation. This study established assessment system severity by using tablets. Twelve ET twelve PD were tested to establish algorithms, six additional the developed evaluate its performance. The also performed spiral three guiding paradigms tablet: traced along given (S1),...
Single-dose benzathine penicillin G (BPG) is the preferred therapy for early syphilis, but poorer serologic responses have been observed among people with HIV (PWH). No enhanced regimen has previously shown to improve outcomes of syphilis.We conducted a retrospective study compare treatment single-dose BPG combined 7-day doxycycline versus alone in PWH who presented syphilis. Rapid plasma reagin (RPR) titers were determined every 3-6 months all included PWH. Serologic response was defined as...
Patients with hematological malignancies (HM) were at a high risk of developing severe disease from coronavirus 2019 (COVID-19). We aimed to assess the clinical outcome COVID-19 in hospitalized patients HM. Adult HM who laboratory-confirmed between May, 2021 and November, 2022 retrospectively identified. Primary was respiratory failure requiring mechanical ventilation or mortality within 60 days after hospitalization. also analyzed associated factors for de-isolation (defined as...
Monkeypox (Mpox) has emerged as a global threat since 2022. We reported 14 cases of Mpox in 10 people with HIV (PWH) and 4 without (PWoH), whom 64.3% had sexually transmitted co-infections. Severe complications prolonged viral shedding might occur both PWH PWoH.
Background. The clinical significance of blood lead levels (BLLs) in chronic peritoneal dialysis (CPD) patients was undetermined prior to this study.
Background. Cadmium exposure is related to severity of diabetes and diabetes-related organ damage in diabetic patients. Elevated blood cadmium levels (BCLs) are well known maintenance haemodialysis (MHD) patients but the clinical significance MHD remains unknown.