A5048677171- Antibiotic Resistance in Bacteria
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- HIV/AIDS Research and Interventions
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Nosocomial Infections in ICU
- HIV-related health complications and treatments
- Fungal Infections and Studies
- Infectious Diseases and Mycology
- Infection Control in Healthcare
- Streptococcal Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Central Venous Catheters and Hemodialysis
National Taiwan University Hospital
2016-2025
National Taiwan University
2015-2025
Affiliated Hospital of Nantong University
2025
Nantong University
2025
Yancheng Third People's Hospital
2025
National Yang Ming Chiao Tung University
2009-2021
National Taiwan University of Sport
2020
Guangzhou Sport University
2020
National Health Research Institutes
2019
Engineering Associates (United States)
2018
Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for wide spectrum skin and soft tissue diseases, central nervous system infections, bacteremia, ocular other infections. M. is differentiated into 3 subspecies: subsp. abscessus, massiliense, bolletii. The 2 major subspecies, have different erm(41) gene patterns. This provides intrinsic resistance to macrolides, so the patterns lead treatment outcomes....
Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly the temporal progression of abnormal findings, are limited. We conducted a prospective study clinical, radiologic, hematologic findings SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 June 15, 2003. Fever was most frequent initial symptom, followed by cough, myalgia, dyspnea, diarrhea. Twenty-four had various underlying diseases. Most elevated C-reactive...
ABSTRACT The increasing trend of β-lactam resistance among Enterobacteriaceae is a worldwide threat. isolates causing intra-abdominal infections (IAI) from the Study for Monitoring Antimicrobial Resistance Trends (SMART) collected in 2008 and 2009 Asia-Pacific region were investigated. Detection extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases, carbapenemases was performed by multiplex PCR. A total 699 with positive genotypic results, included Escherichia coli ( n = 443), Klebsiella...
Background.Acinetobacter baumannii complex infections are increasing in prevalence and associated with a high mortality. Biochemical classification tests cannot differentiate A. (genospecies 2) from other genospecies. Genospecies typing offers potential tool to determine whether there major differences pathogenicity among the
Risk factors and outcome in patients who acquire nosocomial infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) are rarely investigated.A multicenter retrospective study was conducted analyze the clinical microbiological data of with A. 10 hospitals around Taiwan from May 2004 December 2006. Comparisons were made between CRAB carbapenem-susceptible (CSAB).One hundred twenty-one carrying (infections, n=91) 127 CSAB n=97) recruited for analysis. Compared infections, had a...
Healthcare-associated infections caused by multidrug-resistant (MDR) pathogens are significantly associated with increased mortality and morbidity. Environmental cleaning can reduce transmission of these but is often inadequate. Adjunctive methods warranted to enhance the effectiveness disinfection particularly in hospital settings where healthcare-associated major concern.We conducted a study examine mobile, automatic device, Hyper Light Disinfection Robot (model: P3), which utilized...
Background Limited data describe the sustained impact of hand hygiene programs (HHPs) implemented in teaching hospitals, where burden healthcare-associated infections (HAIs) is high. We use a quasi-experimental, before and after, study design with prospective hospital-wide surveillance HAIs to assess cost effectiveness HHPs. Methods Findings A 4-year HHP, particular emphasis on using an alcohol-based rub, was April 2004 at 2,200-bed hospital Taiwan. Compliance measured by direct observation...
Abstract Background Risk factors and outcomes in hematological patients who acquire invasive fungal sinusitis (IFS) are infrequently reported the modern medical era. Method A retrospective study of hospitalized with disease was conducted at National Taiwan University Hospital between January 1995 December 2009. Results Clinical characteristics their associated radiographic microbiological findings were analyzed. Forty-six IFS 64 chronic non-invasive enrolled as comparsion. developed more...
Objectives: Since few therapeutic options exist for extensively drug resistant Acinetobacter baumannii, an emerging threat in ICUs worldwide, and comparative prospective studies of colistin-based combination therapies are lacking, our objective was to compare the outcomes patients with drug-resistant A. baumannii bacteremia, treated colistin-carbapenem colistin-tigecycline combinations. Design: Prospective, observational, multicenter study. Setting, Patients, Interventions: Adults bacteremia...
Colistin and tigecycline have both been shown good in vitro activity among multi-drug resistant Acinetobacter baumannii (MDRAB). A comparative study of colistin versus for MDRAB pneumonia is lacking. The enrolled adults with admitted to intensive care units at a referral medical center during 2009–2010. Since there were no standardized minimum inhibitory concentration (MIC) interpretation criteria against A. baumannii, MIC was not routinely tested our hospital. During the periods, also. We...
<h3>Background</h3> The efficacy of a levofloxacin-based regimen as the first-line treatment and clarithromycin-based second-line for <i>Helicobacter pylori</i> infection remains unknown. aim this study was to assess eradication rates these two regimens using different administration sequences. <h3>Methods</h3> Eligible patients were randomised receive LAL: levofloxacin (750 mg once day), amoxicillin (1000 twice day) lansoprazole (30 7 days, or CAL: clarithromycin (500 days. Patients with...
Chlorhexidine has been widely used for hand hygiene to prevent transmission of nosocomial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). However, data on longitudinal surveillance the susceptibility MRSA isolates chlorhexidine are limited.A total 240 obtained in 1990, 1995, 2000 and 2005 at National Taiwan University Hospital (NTUH), a hospital where gluconate was more than 20 years, were included study. susceptibility, molecular typing using multilocus sequence...
Background Evaluation and feedback of hand hygiene (HH) compliance are important elements the WHO multimodal strategy for hospital infection control. Overt observation is recommended, but it may be confounded by Hawthorne effect. Covert offers opportunity to decrease observer bias. In this study we conducted a one year hospital-wide HH promotion program that included medical students (MS) as covert observers. Methods five indications was determined trained validated The overt observers...
We analyzed samples from 13,652 patients who had respiratory cultures positive for mycobacteria in Taiwan during 2000-2012 and found that 56.9% were nontuberculous (NTM). Whereas annual prevalence of tuberculosis decreased the study period, NTM disease colonization increased, particularly among older male patients.
Abstract The coronavirus disease of 2019 (COVID-19) has caused a global pandemic and led to nearly three million deaths globally. As April 2021, there are still many countries that do not have COVID-19 vaccines. Before the vaccines were developed, some evidence suggested an influenza vaccine may stimulate nonspecific immune responses reduce risk infection or severity illness after infection. This study evaluated association between vaccination We conducted retrospective cross-sectional with...