A5047717026- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- HIV Research and Treatment
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- Infectious Diseases and Tuberculosis
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- HIV, Drug Use, Sexual Risk
- Renal Transplantation Outcomes and Treatments
- Reproductive tract infections research
- Liver Disease Diagnosis and Treatment
- Nail Diseases and Treatments
- Infectious Diseases and Mycology
- Organ Transplantation Techniques and Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
National Taiwan University Hospital
2016-2025
Zhongshan Hospital
2023
Fudan University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Institute of Hematology & Blood Diseases Hospital
2023
National Taiwan University
2012-2022
National Yang Ming Chiao Tung University
2020
National Health Research Institutes
2006-2019
GTx (United States)
2019
University of Benin
2012-2014
Mucormycosis is a devastating invasive fungal disease whose incidence has increased during the past decade. now represents major threat in transplant recipients, accounting for 2% and 8% of infections recent cohorts solid-organ allogeneic stem-cell respectively. most often occurs late, >3 months after transplantation, although cases occurring early have been observed, especially among liver recipients graft-transmitted infection. Recent guidelines emphasized direct examination involved fluid...
Objectives: Since few therapeutic options exist for extensively drug resistant Acinetobacter baumannii, an emerging threat in ICUs worldwide, and comparative prospective studies of colistin-based combination therapies are lacking, our objective was to compare the outcomes patients with drug-resistant A. baumannii bacteremia, treated colistin-carbapenem colistin-tigecycline combinations. Design: Prospective, observational, multicenter study. Setting, Patients, Interventions: Adults bacteremia...
Colistin and tigecycline have both been shown good in vitro activity among multi-drug resistant Acinetobacter baumannii (MDRAB). A comparative study of colistin versus for MDRAB pneumonia is lacking. The enrolled adults with admitted to intensive care units at a referral medical center during 2009–2010. Since there were no standardized minimum inhibitory concentration (MIC) interpretation criteria against A. baumannii, MIC was not routinely tested our hospital. During the periods, also. We...
Neutralizing anti-interferon-γ autoantibody (nAIGA)-associated immunodeficiency is an emerging medical issue worldwide. In the present study, we describe and discuss clinical features outcomes of patients with nAIGAs disseminated infections by nontuberculous mycobacteria (dNTM). We thoroughly reviewed records all patients. Microorganisms were identified using previously described methods modifications. All data calculated analyzed SPSS software. Among 46 adult dNTM infections, 45 cases...
Rhino-orbital-cerebral disease is a significant manifestation of zygomycosis in solid organ transplant (SOT) recipients. However, its characteristics and outcome are not well addressed.SOT recipients with as per the European Organization for Research Treatment Cancer Mycoses Study Group criteria cohort study at our centers published previously those identified PubMed search from 1950s to November 2009 were studied. Patients mycosis involving sinuses, orbits, or central nervous system (CNS)...
The impact of current transplantation practices on the characteristics cryptococcosis in solid-organ transplant recipients is not well defined. incidence cryptococcal disease among has remained unchanged; however, patients are less likely to present with central nervous system or disseminated and more have limited lungs. Additionally, lipid formulations amphotericin B now used frequently, whereas their use combination flucytosine decreased. overall mortality significantly improved era. Renal...
The prognostic value of procalcitonin (PCT) in patients with sepsis at the emergency department (ED) has not been evaluated. We conducted a prospective observational study to compare PCT on and compared validated score, Mortality Emergency Department Sepsis (MEDS) C-reactive protein (CRP) setting ED an urban, university-based medical center. Five hundred twenty-five consecutive adult admitted fulfilling American College Clinical Pharmacists/Society Critical Care Medicine Consensus Conference...
Incidence of Entamoeba histolytica infection and clinical manifestations treatment response invasive amebiasis (IA) in HIV-infected patients have rarely been investigated before.At the National Taiwan University Hospital, medical records who received a diagnosis IA between 1994 2005 were reviewed. The incidence was serial blood stool samples from 670 264 patients, respectively, using serological specific amebic antigen assays. DNA extracted containing E. analyzed by PCR, sequenced, compared....
Risk factors including how changes in immunosuppression influence the occurrence of immune reconstitution syndrome (IRS) solid organ transplant (SOT) recipients with cryptococcosis have not been fully defined.SOT were identified and followed for 12 months. IRS was defined based on previously proposed criteria.Of 89 SOT recipients, 13 (14%) developed IRS. Central nervous system (CNS) disease (adjusted odds ratio [AOR], 6.23; P = .03) discontinuation calcineurin inhibitor (AOR, 5.11; .02)...
To evaluate the evolution of weight and lipid profiles before after switch to co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) among virally suppressed HIV-positive patients.Patients switching E/C/F/TAF between March July 2018 were included. Weight, profile (triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C)), glycated hemoglobin (HbA1c) levels at 48 weeks analyzed using generalized estimating equations in...
Background Concurrent sexually transmitted infections (STIs) are common in active populations. We aimed to estimate the prevalence and coinfection rates of bacterial STIs among active, HIV-positive men who have sex with (MSM), assess potential benefits different combination treatment regimens managing concurrent STIs. Methods From September 2021 2023, MSM underwent STI testing when they had symptoms suggestive or recently acquired hepatitis C virus (HCV) infection early syphilis. The oral...
Galactomannan (GM) is a heteropolysaccharide in the cell walls of most Aspergillus and Penicillium species. Cross-reactivity Cryptococcus neoformans galactoxylomannan an GM test has also been reported. In this study, we used Platelia enzyme immunoassay kit (Bio-Rad) to serum samples obtained from 48 human immunodeficiency virus (HIV)-infected patients (15 with penicilliosis [7 fungemia alone, 4 cavitary lung lesions 3 both lesions, 1 disseminated disease], 22 cryptococcosis [11 5 both,...
Evolution of serological markers hepatitis B virus (HBV) carriage or infection has rarely been investigated among human immunodeficiency (HIV)-infected patients receiving highly active antiretroviral therapy (HAART).During the period 1997-2002, a total 633 HIV-infected were tested for HBV at baseline, including surface antigen (HBsAg), antibody to HBsAg (anti-HBs ), core (anti-HBc), C (HCV) (anti-HCV) antibody, HCV RNA level, and DNA all which retested least 1 year apart. Medical records...