A5078713318- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Lung Cancer Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- Lung Cancer Treatments and Mutations
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- COVID-19 diagnosis using AI
- Radiomics and Machine Learning in Medical Imaging
- Gut microbiota and health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gas Sensing Nanomaterials and Sensors
- Analytical Chemistry and Chromatography
- Respiratory and Cough-Related Research
- Actinomycetales infections and treatment
- Intensive Care Unit Cognitive Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
National Taiwan University Hospital
2016-2025
National Taiwan University
2015-2024
University of Florida
2019
Columbus Oncology and Hematology Associates
2019
National Yang Ming Chiao Tung University
2019
Tao Yuan General Hospital
2009-2016
Ministry of Health and Welfare
2016
Bruker (United States)
2015
Janssen (Belgium)
2015
Gilead Sciences (United States)
2015
Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for wide spectrum skin and soft tissue diseases, central nervous system infections, bacteremia, ocular other infections. M. is differentiated into 3 subspecies: subsp. abscessus, massiliense, bolletii. The 2 major subspecies, have different erm(41) gene patterns. This provides intrinsic resistance to macrolides, so the patterns lead treatment outcomes....
(1) Background: Lung cancer is silent in its early stages and fatal advanced stages. The current examinations for lung are usually based on imaging. Conventional chest X-rays lack accuracy, computed tomography (CT) associated with radiation exposure cost, limiting screening effectiveness. Breathomics, a noninvasive strategy, has recently been studied extensively. Volatile organic compounds (VOCs) derived from human breath can reflect metabolic changes caused by diseases possibly serve as...
Sepsis-related mortality has been found increased in RAG-1 knockout mice. However, patients admitted to medical intensive care units, it is unknown whether severe lymphocyte depletion at admission associated with interleukin (IL)-7 and IL-15 levels circulation, mortality. We prospectively enrolled 92 who were units for sepsis or septic shock. At admission, 24 (26.1%) had lymphopenia, defined as counts of less than 0.5 × 10(3)/μL. Severe lymphopenia was significantly higher plasma tumor...
CNS infections caused by non-tuberculous mycobacteria (NTM) are rare and only three cases of due to Mycobacterium abscessus complex have been reported.We searched the Mycobacteriology Database National Taiwan University Hospital identified patients with NTM.A total 15 patients, namely 4 HIV-seropositive 11 HIV-seronegative NTM were during 2000-10. All had disseminated avium infections. Among M. in 8 2 kansasii 1 patient. six preserved isolates confirmed be massiliense erm(41) PCR 23S rRNA...
ABSTRACT We describe six patients with hospital-acquired bacteremia caused by Methylobacterium species, including M. radiotolerans ( n = 2), thiocyanatum aminovorans 1), and lusitanum which were confirmed to species level 16S rRNA gene sequence analysis. Among these patients, five had catheter-related all favorable outcomes.
We evaluated the real-world efficacy and side effects of afatinib as a first-line therapy for advanced EGFR mutation-positive lung adenocarcinoma. The medical records patients receiving after National Health Insurance reimbursement between May 2014 January 2016 were reviewed, information on patient characteristics treatment courses collected consecutively. Rebiopsy tissue was mutation MET amplification analyses. detected by fluorescence in situ hybridization immunohistochemistry. In total,...
The aim of this study was to delineate the association between high macrophage migration inhibitory factor (MIF) and interleukin 10 (IL-10) levels in early phase sepsis rapidly fatal outcome.One hundred fifty-three adult subjects with main diagnosis severe (including septic shock) admitted directly from emergency department two tertiary medical centers one regional teaching hospital January 2009 December 2011, were included prospectively. MIF IL-10 measured outcomes analyzed by Cox...
Timely differentiating between pulmonary tuberculosis (TB) and nontuberculous mycobacterial lung disease (NTM-LD), which are radiographically similar, is important because infectiousness treatment differ. This study aimed to evaluate whether artificial intelligence could distinguish TB or NTM-LD patients by chest X-rays (CXRs) from suspects of disease.A total 1500 CXRs, including 500 each with TB, NTM-LD, clinical suspicion but negative culture (Imitator) two hospitals, were retrospectively...
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB). Evidence has linked the DM-related dysbiosis of gut microbiota to modifiable host immunity Mycobacterium infection. However, crosslinks between composition and immunological effects on development latent TB infection (LTBI) in DM patients remain uncertain.We prospectively obtained stool, blood samples, medical records from 130 with poorly-controlled (pDM), defined as ever having an HbA1c > 9.0% within previous 1 year. Among...
Abstract Background Lipids are known to be involved in carcinogenesis, but the associations between lipid profiles and different lung cancer histological classifications remain unknown. Methods Individuals who participated national adult health surveillance from 2012 2018 were included. For patients developed during follow-up, a 1:2 control group of nonlung participants was selected after matching. Multivariate conditional logistic regression used explore profiles, epidermal growth factor...
We describe 16 patients with bacteremia caused by Eggerthella lenta (n = 7), Paraeggerthella hongkongensis 3), Eubacterium limosum 4), callanderi 1), and concomitant limosum/Eggerthella 1). Nine (56%) had polymicrobial bacteremia. The overall 60-day mortality rate was 19%, all deaths occurred in E.
ABSTRACT Among 36 Mycobacterium masilliense and 22 M. abscessus isolates identified by erm (41) PCR sequencing analysis of rpoB 23S rRNA genes, the rate accurate differentiation between these two subspecies was 100% cluster spectra generated Bruker Biotyper matrix-assisted laser desorption ionization–time flight mass spectrometry.
Abstract Background Although electronic nose (eNose) has been intensively investigated for diagnosing lung cancer, cross-site validation remains a major obstacle to be overcome and no studies have yet performed. Methods Patients with as well healthy control diseased groups, were prospectively recruited from two referral centers between 2019 2022. Deep learning models detecting cancer eNose breathprint developed using training cohort one site then tested on the other site. Semi-Supervised...
ObjectivesThe weekly rifapentine plus isoniazid for 3 months (3HP) improves completion rate of latent tuberculosis infection treatment, but flu-like symptoms are common. The novel 1HP regimen, involving daily 28 days, has demonstrated low toxicity in HIV-infected populations. We aimed to investigate whether a lower incidence systemic drug reaction (SDR) compared with 3HP during treatment non-HIV populations.MethodsThis randomized, multicentre trial the and risks SDRs aged ≥13 years subjects...
Abstract Background Poor control of diabetes mellitus (DM) increases active tuberculosis (TB) risk. Understanding risk factors for latent TB infection (LTBI) in this population and intervention completion rates is crucial policy making. Methods Under a collaborative multidisciplinary team consisting public health professionals, endocrinologists, pulmonologists, patients aged >45 years with poorly controlled DM (pDM), defined as having glycated hemoglobin level ≥9% within the preceding...