A5083368940- Tuberculosis Research and Epidemiology
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Pleural and Pulmonary Diseases
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Methemoglobinemia and Tumor Lysis Syndrome
- Colorectal Cancer Treatments and Studies
- Medical Imaging and Pathology Studies
- Gallbladder and Bile Duct Disorders
- Diagnosis and treatment of tuberculosis
- Pericarditis and Cardiac Tamponade
- Head and Neck Cancer Studies
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Lung Cancer Research Studies
- Infectious Diseases and Mycology
- Immune Response and Inflammation
- Salivary Gland Tumors Diagnosis and Treatment
- Infectious Encephalopathies and Encephalitis
- Cancer, Stress, Anesthesia, and Immune Response
- Esophageal Cancer Research and Treatment
National Taiwan University Hospital
2015-2024
University of Florida
2019
Columbus Oncology and Hematology Associates
2019
(1) Background: Lung cancer is silent in its early stages and fatal advanced stages. The current examinations for lung are usually based on imaging. Conventional chest X-rays lack accuracy, computed tomography (CT) associated with radiation exposure cost, limiting screening effectiveness. Breathomics, a noninvasive strategy, has recently been studied extensively. Volatile organic compounds (VOCs) derived from human breath can reflect metabolic changes caused by diseases possibly serve as...
Sepsis-related mortality has been found increased in RAG-1 knockout mice. However, patients admitted to medical intensive care units, it is unknown whether severe lymphocyte depletion at admission associated with interleukin (IL)-7 and IL-15 levels circulation, mortality. We prospectively enrolled 92 who were units for sepsis or septic shock. At admission, 24 (26.1%) had lymphopenia, defined as counts of less than 0.5 × 10(3)/μL. Severe lymphopenia was significantly higher plasma tumor...
Treatment of latent tuberculosis (TB) infection (LTBI) effectively prevents its progression to active TB. However, long treatment duration and drug-related hepatotoxicity limit the effectiveness 9-month daily isoniazid (9H). Data on 3-month weekly rifapentine plus (3 HP) in Asian populations are currently unavailable. We prospectively randomised LTBI contacts aged ≥12 years with positive tuberculin skin test into 9H 3 HP groups four hospitals between January 2014 May 2016 Taiwan. The primary...
Endobronchial ultrasound (EBUS) elastography is a new technique that provides information on tissue compressibility during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The purposes of this study were to evaluate the utility EBUS in differentiating malignant and benign mediastinal lymph nodes (LNs) explore factors influence its accuracy. A retrospective chart review patients who underwent EBUS-TBNA from October 2016 July 2017 was performed. with conventional...
Despite numerous studies, there has been little progress in the use of biomarkers for predicting treatment response patients with tuberculosis (TB). Patients culture-confirmed pulmonary TB between 2010 and 2014 were prospectively recruited. Blood samples taken upon diagnosis 2 months after start standard anti-TB treatment. A pilot study utilizing measurement TB-antigen-stimulated cytokines was conducted to select potential further testing. Outcome defined as persistent culture positivity at...
Rapid on-site cytologic evaluation (ROSE) has been shown to improve the diagnostic accuracy of endobronchial ultrasound-guided transbronchial biopsy (EBUS-TBB). However, ROSE by a cytopathologist or cytotechnologist is not always available during procedure. The purposes this study were verify that pulmonologist, after receiving training in cytology, could accurately assess an EBUS-TBB specimen on-site, and evaluate contribution EBUS-TBB. A retrospective chart review patients who underwent...
Acute kidney injury (AKI) is occasionally detected in patients receiving anti-tuberculosis (TB) treatment. This prospective cohort study the first to investigate incidence, risk factors, and renal outcomes of AKI during anti-TB was conducted from January 1, 2016, May 31, 2018. Patients with a new diagnosis TB on standard treatment were enrolled, received regular laboratory monitoring. defined according Kidney Disease: Improving Global Outcome (KDIGO) criteria. Urinalysis, ultrasonography,...
Through activation of adrenergic receptors, chronic stress can trigger the secretion neurotransmitters and hormones that enhance tumor growth, increase angiogenesis, promote drug resistance. This study aimed to evaluate effect β-blockers in patients receiving first-line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for lung adenocarcinoma.This retrospective cohort enrolled with advanced adenocarcinoma under EGFR-TKIs between 2011 2014 National Health Insurance...
While evidence is accumulating that platelets contribute to tissue destruction in tuberculosis (TB) disease, it still not known whether antiplatelet agents are beneficial TB patients. We performed this retrospective cohort study and identified incident cases the Taiwan National Tuberculosis Registry from 2008 2014. These were further classified into users non-users according use of prior diagnosis, cohorts matched using propensity scores (PSs). The primary outcome was survival after a...
Abstract Animal studies have demonstrated that metformin exerts a renoprotective effect. Human of patients with diabetes mellitus (DM) regarding the association use end‐stage renal disease (ESRD) are lacking. Patients type 2 DM and without history kidney who were enrolled under pay‐for‐performance program National Health Insurance in Taiwan identified. Those received ≥90 cumulative defined daily doses within 1 year selected (metformin users) compared 1:1 propensity score–matched nonuser...
The aim of this study was to identify easy and relatively effective ultrasound criteria for metastatic mediastinal lymph node prediction.A retrospective chart review patients who underwent endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) from March 2014 September 2016 performed. We used the following EBUS sonographic features prediction: 1) length short axis, 2) shape, 3) margin, 4) echogenicity, 5) central hilar structure, 6) coagulation necrosis sign. These...
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is now the standard for mediastinal lymph node staging of lung cancer. Training and maintenance technical skills very important in order to apply new techniques clinical use.A retrospective chart review was performed patients who underwent EBUS-TBNA from November 2009 December 2015. We assessed learning curve, accuracy (%), whether this procedure shortened duration cancer staging.The curve continued improve beyond...
Abstract Among treatment modalities for lung cancer, the most promising therapy is use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs). Both erlotinib and gefitinib, two first‐generation EGFR‐TKIs, exhibit significant clinical responses patients with adenocarcinoma. However, few studies have compared effects these drugs, results been inconclusive because small sample sizes in studies. Therefore, this study was conducted to investigate issue. This retrospective...
The difference of macrophage-specific interleukin-1 beta (IL-1b) response between latent tuberculosis infection (LTBI) and active (TB) remains less studied. We performed this prospective study recruited TB patients, contacts with LTBI, uninfected contacts. gene protein expression human monocyte-derived macrophage (hMDM) after ex vivo stimulation by early secretory antigenic target-6KD (ESAT-6) tuberculin purified derivatives (PPD) was studied real-time PCR flow cytometry. effect caspase-1...
A previously healthy 52-year-old man was admitted with fever, headache and drowsiness of one day's duration. He had neck stiffness equivocal Kernig Brudzinski signs. Cerebrospinal fluid showed an elevated protein level, a normal glucose concentration lymphocytic pleocytosis. The
Tuberculosis (TB) remains one of the major infectious diseases worldwide. Adverse reactions are common during TB treatment. Few reports, however, available on treatment-related acute biliary events (ABEs), such as cholelithiasis, obstruction, cholecystitis, and cholangitis. We first report four pulmonary patients who developed ABEs anti-TB Abdominal sonography revealed multiple gall stones with dilated intrahepatic ducts in three cholecystitis patient. To investigate incidence risk factors...
Endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB) is a common procedure used to diagnose peripheral pulmonary lesions (PPLs). However, existing literature did not conclusively show difference in the ability of EBUS-TBB with and without guide sheath (GS) PPLs. This multicenter cohort study enrolled patients presenting for PPLs that finally proved be malignant. The diagnostic yield complication rate were compared between undergoing GS (EBUS-TBB+GS versus EBUS-TBB−GS). A...
Background: Comprehensive rehabilitation programs are recommended for patients with prolonged mechanical ventilation (PMV) to facilitate functional recovery and ventilator weaning, but whether the status after influences outcome has not been clearly evaluated. This study aimed investigate association between post-rehabilitation weaning survival in PMV patients. Methods: We retrospectively enrolled admitted respiratory care center (RCC), a post-ICU facility protocolized program, from January...
The association of toll-like receptors (TLRs) and matrix metalloproteinases (MMPs) single-nucleotide polymorphisms (SNPs) among latent tuberculosis (TB) infection active TB remained less studied.We recruited participants with disease (active TB) (n = 400) (latent infection) 203) in this study. We genotyped SNPs TLR1, TLR2, TLR4, MMP1, MMP8, MMP9, MMP12, tissue inhibitor MMP2. Single-variant analysis haplotype were performed, a polygenic risk score (PRS) was created.We found that TLR1...