A5042301785- Nephrotoxicity and Medicinal Plants
- Drug-Induced Hepatotoxicity and Protection
- Heavy Metals in Plants
- Advanced Glycation End Products research
- Renal Diseases and Glomerulopathies
- Trace Elements in Health
- Chronic Kidney Disease and Diabetes
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Metabolism and Genetic Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Tryptophan and brain disorders
- Pharmacology and Obesity Treatment
- Diabetes Treatment and Management
- Gout, Hyperuricemia, Uric Acid
- Tuberculosis Research and Epidemiology
- Schizophrenia research and treatment
- Acute Kidney Injury Research
- Drug Transport and Resistance Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Heavy Metal Exposure and Toxicity
- Biomedical Research and Pathophysiology
- Gastrointestinal motility and disorders
- Venous Thromboembolism Diagnosis and Management
- Chemotherapy-induced organ toxicity mitigation
Taipei Medical University
2014-2024
Providence University
2024
National Central University
2023
National Defense Medical Center
2019-2023
Taoyuan Armed Forces General Hospital
2023
Chung Shan Medical University
2017
Chang Gung University
2005-2014
Health First
2012
Chang Gung Memorial Hospital
2005
Taiwan Adventist Hospital
2002
Abstract Aristolochic acids (AA), present in Aristolochia plants, are the toxin responsible for Chinese herbs nephropathy (CHN), a rapidly progressive tubulointerstitial nephritis (TIN). To clarify mechanisms of development CHN, we tried to induce TIN mice using AA. Three strains inbred mice, BALB/c, C3H/He and C57BL/6, received 2.5 mg kg−1 AA or sodium salt (AANa) daily by intraperitoneal oral administration, 5 days week 2 weeks. Serum renal tissue were obtained at sacrifice. Twelve-hour...
// Shih-Ming Chen 1 , Bing-Yen Wang 2, 3, 4, 5 Che-Hsin Lee 6 Hsueh-Te 7 Jung-Jung Li 8 Guan-Ci Hong Yu-Chieh Hung Peng-Ju Chien Che-Ying Chang Li-Sung Hsu and Wen-Wei 8, 9 Institute of Biochemistry, Microbiology Immunology, Chung Shan Medical University, Taichung, Taiwan 2 Division Thoracic Surgery, Department Changhua Christian Hospital, City, 3 School Medicine, 4 College Kaohsiung Kaohsiung, Genomics Bioinformatics, National Hsing Biological Sciences, Sun Yat-sen Anatomy Cell Biology,...
Human studies on the use of metformin as host-directed therapy (HDT) for tuberculosis (TB) are rare. We performed a nationwide cohort study to evaluate effect mitigating risk active TB among patients with diabetes mellitus (DM). Among newly diagnosed DM identified in Taiwan National Health Insurance Research Database, users, defined basis >90 cumulative daily doses within 1 year, and propensity-score-matched nonusers were selected. The primary outcome was incident TB, using diagnostic...
Astragalus membranaceus, a traditional Chinese herb, has been used to improve airway inflammation and asthma. The present study investigated whether A. membranaceus immunotherapeutic effects on asthma, chronic inflammatory mucosal disease that is associated with excess production of IgE, eosinophilia, T helper 2 (Th2) cytokines, bronchial hyperresponsiveness. An ovalbumin (OVA)-induced, murine asthma model was examine the status pulmonary after administration membranaceus. IgE levels in...
Methylglyoxal (MG) can cause protein glycation, resulting in cell damage and dysfunction. Accumulation of MG its downstream metabolite N (ε)-(carboxyethyl)lysine (CEL) has been identified several variations nephropathy, including diabetic, hypertensive, gentamicin-induced nephropathies. In this study, we investigated the effects low-molecular-weight chitosan (lmw-chitosan) on MG-induced carbonyl stress aristolochic acid-induced nephropathy. We used a buffer to investigate whether could be...
OBJECTIVES To evaluate the efficacy of ultrasound‐guided percutaneous closed drainage in management abscesses head and neck. STUDY DESIGN Prospective, controlled study. METHODS From January 1998 to December 1999, patients presenting with a unilocular abscess neck who subsequently underwent echo‐guided were enrolled RESULTS Fourteen No needed open surgical afterward. By our protocol, only 8 had an indwelling catheter. After treatment, all cured their disease completely without any...
Abstract Background Collagen-like surface proteins Scl1 and Scl2 on Streptococcus pyogenes contain contiguous Gly-X-X triplet amino acid motifs, the characteristic structure of human collagen. Although potential role in adhesion has been studied, conclusions may be affected by use different S. strains their carriages various adhesins. To explore bona fide nature adherence to epithelial cells without interference other streptococcal factors, we constructed a scl1 isogenic mutant from...
Noise-induced hearing loss (NIHL) often results in impaired functional and accidental injuries; thus, reducing military performance endangering flight safety. While a few studies addressing laterality (left-right ear differences) NIHL incidence between fixed-winged (jet-fighter) rotary-wing (helicopter) aircrafts yielded inconsistent results, little is known about the profile among different types of jet-fighter pilots. This study aims to conduct fine-grained examination Airforce jet pilots,...
Lead (Pb) is an environmental pollutant associated with several diseases, such as nephrotoxicity. Methylglyoxal (MG) a reactive dicarbonyl compound formed during glycolysis and reported to increase in kidney damage. Metformin used MG scavenger the clinic. In this study, we investigated mechanism of Pb-induced renal injury effect metformin on Eighteen Wistar rats were randomly divided into three groups: control, Pb, Pb + groups. (250 ppm) was administered drinking water, 50 mg/kg...
Aminoglycosides are widely used to treat infections; however, their applications limited by nephrotoxicity. With the increase of antibiotic resistance, use aminoglycosides is inevitable. Low-molecular-weight chitosan (LMWC) has shown renal protective effects in dialysis patients. However, no study evaluated LMWC for preventing aminoglycoside-induced nephrotoxicity or determined mechanisms underlying effects. In this study, (165 825 mg/kg/day) metformin (100 was orally administered 13 days...
Aristolochic acid (AA) causes interstitial renal fibrosis, called aristolochic nephropathy (AAN). There is no specific indicator for diagnosing AAN, so this study aimed to investigate the biomarkers AAN using a proteomics method. The C3H/He female mice were given ad libitum AA-distilled water (0.5 mg/kg/day) and distilled 56 days in AA normal groups, respectively. AA-induced proteins kidney investigated study, including fluorogenic derivatization with...