A5049626738- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- HIV/AIDS drug development and treatment
- Infective Endocarditis Diagnosis and Management
- HIV/AIDS Research and Interventions
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Antibiotics Pharmacokinetics and Efficacy
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- Antifungal resistance and susceptibility
- HIV Research and Treatment
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Antibiotic Use and Resistance
- Hepatitis Viruses Studies and Epidemiology
- Streptococcal Infections and Treatments
- Vibrio bacteria research studies
- Infectious Diseases and Mycology
- Actinomycetales infections and treatment
- Respiratory viral infections research
- HIV, Drug Use, Sexual Risk
National Taiwan University Hospital
2016-2025
National Synchrotron Radiation Research Center
2021-2023
University of Pennsylvania
2023
National Taiwan University
2012-2022
National University of Kaohsiung
2011-2019
National Health Research Institutes
2019
Far Eastern Memorial Hospital
2014-2018
Institute of Clinical Research
2017
University of Hawaiʻi at Mānoa
2013
Taichung Veterans General Hospital
2009
Background.Acinetobacter baumannii complex infections are increasing in prevalence and associated with a high mortality. Biochemical classification tests cannot differentiate A. (genospecies 2) from other genospecies. Genospecies typing offers potential tool to determine whether there major differences pathogenicity among the
<h3>Background</h3> Tuberculous pleurisy is traditionally indicated by extreme lymphocytosis in pleural fluid and low yield of effusion culture. However, there considerable inconsistency among previous study results. In addition, these data should be updated due to early studies advances culture methods. <h3>Methods</h3> From January 2004 June 2009, patients with tuberculous were retrospectively identified from the mycobacteriology laboratories pathology tuberculosis registration databases...
Objectives: Since few therapeutic options exist for extensively drug resistant Acinetobacter baumannii, an emerging threat in ICUs worldwide, and comparative prospective studies of colistin-based combination therapies are lacking, our objective was to compare the outcomes patients with drug-resistant A. baumannii bacteremia, treated colistin-carbapenem colistin-tigecycline combinations. Design: Prospective, observational, multicenter study. Setting, Patients, Interventions: Adults bacteremia...
Colistin and tigecycline have both been shown good in vitro activity among multi-drug resistant Acinetobacter baumannii (MDRAB). A comparative study of colistin versus for MDRAB pneumonia is lacking. The enrolled adults with admitted to intensive care units at a referral medical center during 2009–2010. Since there were no standardized minimum inhibitory concentration (MIC) interpretation criteria against A. baumannii, MIC was not routinely tested our hospital. During the periods, also. We...
Treatment options for vancomycin-resistant enterococci (VRE) bloodstream infection (BSI) are limited. Daptomycin, although not currently approved this indication, is frequently used the treatment of VRE-BSI. Its optimal dose still needs to be determined. We conducted a prospective, observational, cohort study during 2010–2015. included patients who received daptomycin ≥6 mg/kg VRE-BSI caused by daptomycin-susceptible VRE. The primary endpoint was 14-day mortality, and multivariable logistic...
To evaluate the evolution of weight and lipid profiles before after switch to co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) among virally suppressed HIV-positive patients.Patients switching E/C/F/TAF between March July 2018 were included. Weight, profile (triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C)), glycated hemoglobin (HbA1c) levels at 48 weeks analyzed using generalized estimating equations in...
Treatment of latent tuberculosis (TB) infection (LTBI) effectively prevents its progression to active TB. However, long treatment duration and drug-related hepatotoxicity limit the effectiveness 9-month daily isoniazid (9H). Data on 3-month weekly rifapentine plus (3 HP) in Asian populations are currently unavailable. We prospectively randomised LTBI contacts aged ≥12 years with positive tuberculin skin test into 9H 3 HP groups four hospitals between January 2014 May 2016 Taiwan. The primary...
Abstract Candida tropicalis is the leading cause of non–C. albicans candidemia in tropical Asia and Latin America. We evaluated isolates from 344 patients with an initial episode C. candidemia. found that 58 (16.9%) were infected by fluconazole-nonsusceptible (FNS) cross resistance to itraconazole, voriconazole, posaconazole; 55.2% (32/58) azole-naive. Multilocus sequence typing analysis revealed FNS genetically closely related, but we did not see time- or place-clustering. Among diploid...
Abstract Background Tenofovir-containing antiretroviral therapy (ART) improves survival in HBV-coinfected people with HIV (PWH). We investigated the incidence of HDV infection and its clinical impact PWH era tenofovir-containing ART. Methods Between 2011 2022, were included followed until December 2023. Anti-HDV antibody screening was performed using sequentially archived blood samples. The timing incident estimated as midpoint between last time point anti-HDV-negative samples first...
Abstract Background Vancomycin-Resistant Enterococcus (VRE) is a predominant pathogen in nosocomial bacteremia (BSI) Taiwan. Although glycopeptides are traditionally recommended for empiric treatment of suspected Gram-positive infections, this study evaluates whether anti-VRE antibiotics improves survival compared to following definitive VRE confirmed by blood culture. Methods This retrospective cohort was conducted at the National Taiwan University Hospital and its branches from January...
Abstract Background The best treatment for vancomycin-resistant enterococcus (VRE) bloodstream infection (BSI) remains controversial. In 2020, the CLSI revised daptomycin breakpoints E. faecium and recommended a high-dose of 8-12 mg/kg/day. However, effectiveness versus linezolid unanswered. most effective PD parameter daptomycin’s is free drug area under curve to minimum inhibitory concentration ratio (fAUC/MIC). This study compares clinical outcomes VRE BSI between patients treated with...
The aim of this study was to develop a grading scale for predicting the 30-day mortality spontaneous intracerebral hemorrhage (ICH) using initial evaluation data.Univariate and multivariate logistic regression models were used identify independent risk factors construct outcome ICH.The Taichung Veterans General Hospital in Taichung, Taiwan.Two hundred ninety-three patients diagnosed with ICH between 1 January 2006 31 December 2007.Development simplified score (sICH score) discrimination...
ABSTRACT Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) (Bruker Biotyper) was able to accurately identify 98.6% (142/144) Acinetobacter baumannii isolates, 72.4% (63/87) A. nosocomialis and 97.6% (41/42) pittii isolates. All junii , ursingii johnsonii radioresistens isolates ( n = 28) could also be identified correctly by Bruker Biotyper.
Abstract Acinetobacter baumannii -induced nosocomial pneumonia has become a serious clinical problem because of high antibiotic resistance rates. Antimicrobial peptides (AMP) are an ideal alternative strategy due to their broad-spectrum antimicrobial activity and low incidence bacterial resistance. However, application is limited by toxicity stability in vivo. The present study used mouse model directly identify potential AMPs effective for treatment A. pneumonia. Fifty-eight were screened...
While some evidence has suggested the benefits of co-formulated bictegravir, emtricitabine and tenofovir alafenamide (B/F/TAF) in improving quality life people living with HIV (PLWH), patient-reported outcome studies that focus on Asian population remain scarce. We aimed to determine changes HIV-related symptom burden virally-suppressed PLWH switching B/F/TAF a real-world setting.PLWH stable antiretroviral therapy (ART) for ≥6 months plasma RNA <200 copies/mL who decided switch were eligible...
The data on immune responses of individuals undergoing MVA-BN vaccination are scarce. We aimed to compare Mpox virus-specific antibody and neutralizing among people with without HIV receiving vaccines. This prospective study enrolled participants two-dose investigate seroresponses after vaccination. Blood samples were collected before each dose for determinations anti-A29 anti-H3 IgG. Neutralization tests conducted tested positive both Overall, 441 enrolled. Seroconversion IgG, respectively,...
On the basis of our finding that antitumor effect 5-{4-[(1-methylcyclohexyl)methoxy]benzyl}thiazolidine-2,4-dione, a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)γ agonist, was, in part, attributable to its ability block glucose uptake independently PPARγ, we used PPARγ-inactive analogue develop novel class transporter (GLUT) inhibitors. This lead optimization led compound 30...