A5101840496- MicroRNA in disease regulation
- Language and cultural evolution
- Machine Learning in Bioinformatics
- Hepatitis Viruses Studies and Epidemiology
- Fractal and DNA sequence analysis
- Genital Health and Disease
- Quinazolinone synthesis and applications
- Polyamine Metabolism and Applications
- Natural Language Processing Techniques
- Smart Grid Security and Resilience
- Biochemical and Molecular Research
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- EFL/ESL Teaching and Learning
- Language, Discourse, Communication Strategies
- Syphilis Diagnosis and Treatment
- Text and Document Classification Technologies
- Axon Guidance and Neuronal Signaling
- Pharmacological Effects of Natural Compounds
- Image and Video Stabilization
- Smart Grid Energy Management
- Hippo pathway signaling and YAP/TAZ
- Handwritten Text Recognition Techniques
- Neurogenetic and Muscular Disorders Research
- Hepatitis C virus research
National Taiwan University Hospital
2024-2025
Institute of Linguistics, Academia Sinica
2024
Institute of Molecular Biology, Academia Sinica
2021-2023
National Yang Ming Chiao Tung University
2021
National Tsing Hua University
2018
I-Shou University
2010
Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by the selective loss of spinal motor neurons (MNs) and concomitant muscle weakness. Mutation SMN1 known to cause SMA, restoring SMN protein levels via antisense oligonucleotide treatment effective for ameliorating symptoms. However, this approach hindered exorbitant costs, invasive procedures, poor responses some patients. Here, we seek circumvent these hurdles identifying reliable biomarkers that could predict...
Abstract Background Tenofovir-containing antiretroviral therapy (ART) improves survival in HBV-coinfected people with HIV (PWH). We investigated the incidence of HDV infection and its clinical impact PWH era tenofovir-containing ART. Methods Between 2011 2022, were included followed until December 2023. Anti-HDV antibody screening was performed using sequentially archived blood samples. The timing incident estimated as midpoint between last time point anti-HDV-negative samples first...
Data regarding the concentrations of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) in Asian population receiving pre-exposure prophylaxis (PrEP) for HIV with tenofovir disoproxil fumarate (TDF) emtricitabine (FTC) (TDF/FTC) are limited, associations between frequency TDF/FTC administration drug concentration among people on-demand PrEP remain unclear. Fifty-seven participants daily 113 were enrolled this study. The TFV-DP FTC-TP measured dried blood spots using...
Though the wavelet transform coefficients (WTCs) contain plenty of information needed for turn-on/off transient signal identification load events, adopting WTCs directly has drawbacks taking a longer time and much memory process non-intrusive monitoring (NILM). To effectively reduce number features representing signals, an energy spectrum in different scales calculated by Parseval's Theorem are proposed presented this paper. The back-propagation (BP) classification system is then used...
Mycoplasma genitalium is an emerging etiology of sexually transmitted infections (STIs) with increasing resistance to antimicrobials. Surveillance on the epidemiology M. infection and antimicrobial warranted.
Although the function of microRNAs (miRNAs) during embryonic development has been intensively studied in recent years, their postnatal physiological functions remain largely unexplored due to inherent difficulties with presence redundant paralogs same seed. Thus, it is particularly challenging uncover miRNA at neural circuit level since animal behaviors would need be assessed upon complete loss family functions. Here, we focused on MiR34/449 that manifests a dynamic expression pattern spinal...
It has been reported for decades that preschool children (age 4-7) tend to assign non-adult-like interpretations sentences with pre-subject exclusive only. This study reports findings from two experiments investigating (1) the effects of (in)congruent implicit questions in discourse contexts and (2) word order transformation on children's Mandarin zhiyou 'only'. Experiment 1 showed performed incongruent condition, similar patterns found previous studies, but adult-like congruent condition. 2...
Abstract Background The Hippo pathway is conserved through evolution and plays critical roles in development, tissue homeostasis tumorigenesis. Yes‐associated protein (YAP) a transcriptional coactivator downstream of the pathway. Previous studies have demonstrated that activation YAP promotes proliferation developing brain. Whether required for production neural progenitor cells or neurons vivo remains unclear. Results We SATB homeobox 2 (SATB2)‐positive projection (PNs) upper layers, but...
A stroke is defined as a straight line or arc corresponding to segment of character, and character composed one several strokes. novel fast filter which can localize stroke-like structures with very high speed has been proposed in this paper. Compared related work, our attacks the detection problem more efficient way. It uses segments sampling intercept body along both perpendicular axes, then orientation simply be determined by set qualification rules. Much computing redundancy existing...
One of the ultimate goals for linguists is to find universal properties in human languages. Although words are generally considered as representing arbitrary mapping between linguistic forms and meanings, we propose a new law that highlights equally important role syllables, which complementary Zipf's. By plotting rank-rank frequency distribution word syllable English Chinese corpora, visible lines appear can be fit master curve. We discover multi-layer network syllables based on this...
Complex systems, such as life and languages, are governed by principles of evolution. The analogy comparison between biology linguistics\cite{alphafold2, RoseTTAFold, lang_virus, cell language, faculty1, language gene, Protein linguistics, dictionary, Grammar pro_dom, complexity, genomics_nlp, InterPro, modeling, modeling} provide a computational foundation for characterizing analyzing protein sequences, human corpora, their However, no general mathematical formula has been proposed so far...