A5079129261- Neurogenesis and neuroplasticity mechanisms
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Axon Guidance and Neuronal Signaling
- MicroRNA in disease regulation
- Developmental Biology and Gene Regulation
- Bone Tissue Engineering Materials
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Congenital heart defects research
- Cancer-related Molecular Pathways
- Neuroscience and Neuropharmacology Research
- Aerogels and thermal insulation
- Anesthesia and Neurotoxicity Research
- Language Development and Disorders
- Phosphodiesterase function and regulation
- Lysosomal Storage Disorders Research
- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
- Facial Trauma and Fracture Management
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- Animal Vocal Communication and Behavior
National Taiwan Normal University
2011-2024
National Yang Ming Chiao Tung University
1998-2014
University of Michigan
2004-2006
Dentate granule cell (DGC) neurogenesis persists throughout life in the mammalian hippocampal dentate gyrus and increases after epileptogenic insults. The DGC layer human experimental mesial temporal lobe epilepsy (mTLE) often shows abnormal dispersion appearance of hilar-ectopic DGCs. In pilocarpine mTLE model, DGCs arise as a result an aberrant chain migration neural progenitors. Reelin is secreted guidance cue that adult rodent hippocampus. We tested hypothesis loss epileptic leads to...
Neural precursors persist throughout life in the rodent forebrain subventricular zone (SVZ) and hippocampal dentate gyrus. The regulation of persistent neural stem cells is poorly understood, part because lack progenitor markers. Sox B1 subfamily HMG-box transcription factors (Sox1-3) expressed by embryonic nervous system, where these maintain progenitors an undifferentiated state while suppressing neuronal differentiation. Sox2 expression persists germinative zones adult brain, but Sox3...
Neurogenesis persists throughout life in the rodent subventricular zone (SVZ)-olfactory bulb pathway. The molecular regulation of this neurogenic circuit is poorly understood. Because components for retinoid signaling are present pathway, we examined influence retinoic acid (RA) on postnatal SVZ-olfactory neurogenesis. Using both SVZ neurosphere stem cell and parasagittal brain slice cultures derived from mouse, found that RA exposure increased neurogenesis by enhancing proliferation...
Mutations of the transcription factor FOXP2 in humans cause a severe speech and language disorder. Disruption Foxp2 songbirds or mice also leads to deficits song learning ultrasonic vocalization, respectively. These data suggest that plays important roles developing nervous system. However, mechanism regulating neural development remains elusive. In current study, we found increased neuronal differentiation without affecting cell proliferation survival primary progenitors from embryonic...
Abstract The Hippo pathway is a key signaling cascade in controlling organ size. core components of this are two kinases, (Hpo) and Warts (Wts), transcriptional coactivator, Yorkie (Yki). Yes-associated protein (YAP, Yki homolog mammals) promotes epithelial–mesenchymal transition cell migration vitro. Here, we use border cells the Drosophila ovary as model to study functions vivo. During oogenesis, polar secrete Unpaired (Upd), which activates JAK/STAT neighboring specifies them into outer...
The Hippo pathway is conserved and plays important roles in organ size control. core components of the are two kinases (Hpo), Warts (Wts), a transcription-co-activator Yorkie (Yki). Yki activity regulated by phosphorylation, which affects its nuclear localization stability. To determine role stem cells, we examine follicle cells (FSCs) Drosophila ovary. detected nucleus FSCs. Knockdown yki cell lineage leads to disruption follicular epithelium. Mitotic clones FSCs mutant for hpo or wts...
Significance Neural activity in the adult brain plays a key role mediating experience-dependent neural plasticity. We show that inhibiting electrical song nucleus, robust nucleus of arcopallium, bird decreases number new projection neurons added to afferent HVC. Our results are consistent with general principle activity-based target selection newborn during nervous system development and support idea developmental plasticity exploit similar mechanisms. Understanding mechanisms influencing...
Accumulating evidence implies that both AKT1 and GABAA receptor (GABAAR) subunit genes are involved in schizophrenia pathogenesis. Activated Akt promotes GABAergic neuron differentiation increases GABAAR expression on the plasma membrane. To elucidate role of Akt1 modulating functions schizophrenia-related cognitive deficits, a set 6 vitro vivo experiments was conducted. First, an Akt1/2 inhibitor applied to evaluate its effect neuron-like cell formation from P19 cells. Inhibiting resulted...
Chinese herbal medicines (CHMs) have been used to treat human diseases for thousands of years. Among them, Ginkgo biloba is reported be beneficial the nervous system and a potential treatment neurological disorders. Since presence adult neural stem cells (NSCs) brings hope that brain may heal itself, whether effect on NSCs remains elusive. In this study, we found extract (GBE) one its main ingredients, ginkgolide B (GB) promoted cell cycle exit neuronal differentiation in derived from...
Mutations in ATP13A2 have been reported to associate with Parkinson's disease (PD). This study investigates the contribution of genetic variants Taiwanese PD. cDNA fragments from 65 early onset PD (onset <50 years) were sequenced. The identified validated a cohort (n = 493) and ethnically matched controls 585). A novel heterozygous G1014S, located at conserved seventh transmembrane domain protein, was an patient, which absent 585 normal controls. Additionally, A746T found two patients four...
The aim of this study was to investigate the distribution a calcium-inhibitable adenylyl cyclase type VI (type AC) in central nervous system using an antiserum directed against N-terminus AC. Our results indicate that AC immunoreactivity is generally expressed many brain regions with different levels intensity. Most interestingly, majority detected present cells neuronal phenotype. Double immunostaining and markers various neurotransmitter systems suggest might participate regulation...
Accumulating evidence suggests AKT1 and DRD2-AKT-GSK3 signaling involvement in schizophrenia. activity is also required for lithium, a GSK3 inhibitor, to modulate mood-related behaviors. Notably, inhibitor significantly alleviates behavioral deficits Akt1-/- female mice, whereas typical/atypical antipsychotics have no effect. In agreement with adjunctive therapy lithium treating schizophrenia, our data mining indicated that the average utilization rates of Taiwan National Health Insurance...
Postnatal neurogenesis persists throughout life in the subventricular zone (SVZ)-olfactory bulb pathway mammals. Extrinsic or intrinsic factors have been revealed to regulate neural stem cell (NSC) properties and neurogenesis. Thyroid hormone receptor interacting protein 6 (TRIP6) belongs zyxin family of LIM proteins, which shown interact with various proteins mediate cellular functions. However, role TRIP6 NSCs is still unknown.By performing double immunofluorescence staining, we found that...
Abstract In the adult mammalian brain, new neurons are continuously generated from neural stem cells (NSCs) in subventricular zone (SVZ)‐olfactory bulb (OB) pathway. YAP, a transcriptional co‐activator of Hippo pathway, promotes cell proliferation and inhibits differentiation embryonic progenitors. However, role YAP postnatal NSCs remains unclear. Here, we showed that was present mouse SVZ. Forced expression Yap promoted NSC maintenance inhibited differentiation, whereas depletion by RNA...
During development, cortical interneurons generated from the ventral telencephalon migrate tangentially into dorsal telencephalon. Although Achaete-scute family bHLH transcription factor 1 (Ascl1) plays important roles in developing telencephalon, whether Ascl1 regulates tangential migration remains unclear. Here, we found that promoted along ventricular zone/subventricular zone (VZ/SVZ) and intermediate (IZ) of Distal-less homeobox 2 (Dlx2) acted downstream promoting VZ/SVZ but not IZ. We...
Pheromones from urine of unfamiliar conspecific male animals can reinitiate a female's estrus cycle to cause pregnancy block through the vomeronasal organ (VNO)-accessory olfactory bulb (AOB)-hypothalamic pathway. This phenomenon is called Bruce effect. mate female, however, do not trigger re-entrance because an memory toward its formed. The activity VNO-AOB-hypothalamic pathway negatively modulated by GABAergic granule cells in AOB. Since these are constantly replenished neural stem...
Mesoporous bioactive glass (MBG) has gained widespread attention owing to its excellent bioactivity, biodegradability, and non-toxicity. Due these superior properties, MBG found applications in various fields. Yet, common pore-forming agents such soft polymer templates, which could result residual carbon contamination lead decreases biological properties. Thus, this work, we proposed the template-free synthesis via spray drying method. By employing H2O2 as a novel agent, from can be...